Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   CO687_RS08300 Genome accession   NZ_CP023511
Coordinates   1682037..1683443 (-) Length   468 a.a.
NCBI ID   WP_096755252.1    Uniprot ID   -
Organism   Streptococcus gordonii strain FDAARGOS_371     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1677037..1688443
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO687_RS08275 (CO687_08275) - 1677783..1678376 (-) 594 WP_060553637.1 class I SAM-dependent methyltransferase -
  CO687_RS08280 (CO687_08280) coaA 1678482..1679402 (+) 921 WP_045634868.1 type I pantothenate kinase -
  CO687_RS08285 (CO687_08285) rpsT 1679499..1679747 (+) 249 WP_008808726.1 30S ribosomal protein S20 -
  CO687_RS08290 (CO687_08290) - 1679812..1680321 (+) 510 WP_008808727.1 DNA topology modulation protein -
  CO687_RS08295 (CO687_08295) - 1680437..1681888 (+) 1452 WP_172858962.1 alpha-amylase -
  CO687_RS08300 (CO687_08300) ciaH 1682037..1683443 (-) 1407 WP_096755252.1 HAMP domain-containing sensor histidine kinase Regulator
  CO687_RS08305 (CO687_08305) ciaR 1683433..1684107 (-) 675 WP_008808730.1 response regulator transcription factor Regulator
  CO687_RS08310 (CO687_08310) - 1684238..1684693 (-) 456 WP_096755253.1 hypothetical protein -
  CO687_RS08315 (CO687_08315) - 1684877..1685680 (-) 804 WP_061593323.1 SDR family NAD(P)-dependent oxidoreductase -
  CO687_RS08320 (CO687_08320) - 1685695..1686021 (-) 327 WP_096755254.1 multidrug efflux SMR transporter -
  CO687_RS08325 (CO687_08325) - 1686072..1686356 (-) 285 WP_096755255.1 helix-turn-helix transcriptional regulator -

Sequence

Protein


Download         Length: 468 a.a.        Molecular weight: 53385.31 Da        Isoelectric Point: 8.8269

>NTDB_id=247989 CO687_RS08300 WP_096755252.1 1682037..1683443(-) (ciaH) [Streptococcus gordonii strain FDAARGOS_371]
MLNKLRRTFYADDFSYFIRYFGVFTLIFSAMTLLIIQIMRSGLYTTVDDNLKSLSQNPRSVLHLALARAANMQPTIDEGQ
SSDDDTGPQDAPDPGPMDNLKVNSNTEAVLFDEDLKPLTTADHFLSLKKISIKKKDVGKIIQTTLKNNYGQEELYRMLVF
EINPSEFLSGNLLNKVKYAAVLINVNQLEQTSQNHEQIIVIVMISFWLISIIASIYLARVSVKPLIDSMQKQKSFVENAS
HELRTPLAVLQNRLETLFRKPEATIMESSENIASSLEEVRNMRMLTTNLLNLARRDDGIKAEITEVEPEFFTTTFANYEI
IADENEKVFIYENHIDHNIKTDRTLLKQLMTILFDNAVKYTEEDGVIKFIVWSKDRSLYLRVSDNGPGINNEDKKKIFDR
FYRVDKARTRQKGGFGLGLSLAKQIADALKGTITVKDNRPKGTIFEVKISIKSESKKRVGRLNDGKKD

Nucleotide


Download         Length: 1407 bp        

>NTDB_id=247989 CO687_RS08300 WP_096755252.1 1682037..1683443(-) (ciaH) [Streptococcus gordonii strain FDAARGOS_371]
ATGCTGAATAAACTTAGACGAACTTTTTATGCGGATGATTTTTCATATTTCATTCGCTATTTTGGTGTATTCACACTTAT
TTTCTCGGCCATGACTCTTTTAATCATTCAGATTATGCGCTCAGGGCTTTATACAACAGTTGACGATAATTTAAAAAGTT
TAAGTCAGAATCCCAGATCTGTCCTCCACCTTGCTTTGGCTCGTGCAGCCAATATGCAACCAACGATTGATGAGGGTCAG
TCATCTGATGATGATACTGGGCCACAAGACGCCCCAGACCCTGGACCAATGGATAATCTGAAGGTGAATTCGAACACTGA
AGCAGTCTTGTTCGATGAAGACTTGAAACCATTGACTACTGCAGATCATTTTCTTAGTTTAAAAAAGATTTCAATCAAGA
AAAAGGATGTAGGTAAAATTATTCAGACTACTTTGAAAAACAACTATGGTCAAGAAGAACTCTATCGTATGTTGGTTTTT
GAGATTAATCCAAGCGAATTCTTATCTGGGAATCTTTTGAACAAAGTAAAATATGCAGCAGTTTTGATTAATGTCAATCA
ATTGGAGCAAACCAGTCAGAATCATGAACAAATCATTGTCATTGTTATGATTAGTTTCTGGTTAATTTCAATTATTGCCA
GTATTTATTTGGCTCGGGTCAGCGTGAAGCCTCTAATAGACAGTATGCAGAAGCAAAAATCTTTTGTTGAAAACGCCAGC
CATGAGTTGCGTACTCCTTTAGCTGTTTTGCAGAACCGTTTGGAAACTCTTTTCCGAAAACCGGAAGCTACGATTATGGA
ATCTAGTGAAAATATTGCCTCCAGTCTGGAAGAAGTTCGGAATATGCGGATGCTAACAACTAATCTATTGAATCTTGCAA
GAAGAGATGATGGCATTAAGGCTGAAATTACTGAAGTTGAACCAGAATTTTTCACTACAACATTTGCCAACTATGAAATC
ATTGCGGATGAAAATGAGAAAGTATTTATCTACGAAAATCATATCGACCACAACATCAAGACAGATAGAACACTTCTAAA
ACAGCTGATGACTATTCTCTTTGATAATGCTGTGAAATATACAGAAGAAGATGGGGTTATTAAGTTTATAGTATGGTCAA
AAGACCGTTCTCTATACTTACGAGTGTCCGATAACGGCCCTGGAATCAATAATGAAGACAAAAAGAAAATTTTTGATCGT
TTTTATAGGGTTGATAAGGCTAGAACAAGACAAAAGGGTGGTTTTGGTCTAGGTCTATCCCTTGCAAAACAAATTGCCGA
TGCACTAAAGGGTACAATTACTGTTAAGGACAATAGACCTAAAGGTACCATTTTTGAAGTCAAAATTTCCATCAAATCAG
AAAGCAAGAAACGAGTTGGACGATTGAATGATGGAAAAAAAGATTGA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(342-449)

His Kinase A (phospho-acceptor) domain (HisKA)

(233-298)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

65.721

97.863

0.643
  ciaH Streptococcus pneumoniae D39

65.721

97.863

0.643
  ciaH Streptococcus pneumoniae R6

65.721

97.863

0.643
  ciaH Streptococcus pneumoniae TIGR4

65.721

97.863

0.643
  ciaH Streptococcus mutans UA159

54.343

95.94

0.521

Multiple sequence alignment