Detailed information NTG0240552

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: CG712_RS02015
• Genome accession: NZ_CP022547
• Coordinates: 382590..383297 (-)
• Length: 235 a.a.
• NCBI ID: WP_011226084.1
• Uniprot ID: A0A060BQ44
• Organism: Streptococcus thermophilus strain B59671
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 377590..388297

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CG712_RS01990 (CG712_02015)	yidA	377939..378748 (+)	810	WP_011226081.1	sugar-phosphatase	-
CG712_RS01995 (CG712_02020)	-	378750..379964 (+)	1215	WP_096811491.1	aminoacyltransferase	-
CG712_RS02000 (CG712_02025)	-	380016..380377 (-)	362	Protein_388	YbaN family protein	-
CG712_RS02005 (CG712_02030)	vicX	380437..381249 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
CG712_RS02010 (CG712_02035)	vicK	381227..382597 (-)	1371	WP_096811492.1	cell wall metabolism sensor histidine kinase VicK	Regulator
CG712_RS02015 (CG712_02040)	vicR	382590..383297 (-)	708	WP_011226084.1	response regulator YycF	Regulator
CG712_RS02020 (CG712_02045)	-	383824..384591 (+)	768	WP_011226085.1	amino acid ABC transporter ATP-binding protein	-
CG712_RS02025 (CG712_02050)	-	384603..385436 (+)	834	WP_002953142.1	transporter substrate-binding domain-containing protein	-
CG712_RS02030 (CG712_02055)	-	385454..386152 (+)	699	WP_022096755.1	amino acid ABC transporter permease	-
CG712_RS02035 (CG712_02060)	-	386164..386814 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
CG712_RS02040 (CG712_02065)	endA	386886..387767 (-)	882	WP_022096754.1	DNA/RNA non-specific endonuclease	Machinery gene
CG712_RS02045 (CG712_02070)	-	387829..388017 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27073.01 Da
• Isoelectric Point: 5.0130

>NTDB_id=240552 CG712_RS02015 WP_011226084.1 382590..383297(-) (vicR) [Streptococcus thermophilus strain B59671]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=240552 CG712_RS02015 WP_011226084.1 382590..383297(-) (vicR) [Streptococcus thermophilus strain B59671]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: A0A060BQ44

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Streptococcus salivarius strain HSISS4	45.299	99.574	0.451
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.887	98.298	0.451
scnR	Streptococcus mutans UA159	38.559	100	0.387