Detailed information NTG0223208

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: A6J85_RS09400
• Genome accession: NZ_CP020450
• Coordinates: 1881334..1882008 (-)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain FDAARGOS_257
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1876334..1887008

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J85_RS09375 (A6J85_09265)	coaA	1876384..1877304 (+)	921	WP_105165144.1	type I pantothenate kinase	-
A6J85_RS09380 (A6J85_09270)	rpsT	1877401..1877649 (+)	249	WP_008808726.1	30S ribosomal protein S20	-
A6J85_RS09385 (A6J85_09275)	-	1877714..1878223 (+)	510	WP_008808727.1	DNA topology modulation protein	-
A6J85_RS09390 (A6J85_09280)	-	1878339..1879790 (+)	1452	WP_082307662.1	alpha-amylase	-
A6J85_RS09395 (A6J85_09285)	ciaH	1879938..1881344 (-)	1407	WP_061599021.1	cell wall metabolism sensor histidine kinase WalK	Regulator
A6J85_RS09400 (A6J85_09290)	ciaR	1881334..1882008 (-)	675	WP_008808730.1	response regulator transcription factor	Regulator
A6J85_RS09405 (A6J85_09295)	-	1882138..1882554 (-)	417	WP_045634871.1	hypothetical protein	-
A6J85_RS09410 (A6J85_09300)	-	1882738..1883541 (-)	804	WP_045634872.1	SDR family oxidoreductase	-
A6J85_RS09415 (A6J85_09305)	-	1883556..1883882 (-)	327	WP_082307663.1	multidrug efflux SMR transporter	-
A6J85_RS09420 (A6J85_09310)	-	1883933..1884217 (-)	285	WP_045502814.1	helix-turn-helix domain-containing protein	-
A6J85_RS09425 (A6J85_09315)	-	1884400..1886943 (-)	2544	WP_082307664.1	M1 family metallopeptidase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=223208 A6J85_RS09400 WP_008808730.1 1881334..1882008(-) (ciaR) [Streptococcus gordonii strain FDAARGOS_257]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=223208 A6J85_RS09400 WP_008808730.1 1881334..1882008(-) (ciaR) [Streptococcus gordonii strain FDAARGOS_257]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGACGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGGGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTCGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362