Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   A6J85_RS09395 Genome accession   NZ_CP020450
Coordinates   1879938..1881344 (-) Length   468 a.a.
NCBI ID   WP_061599021.1    Uniprot ID   A0AAP7M0C3
Organism   Streptococcus gordonii strain FDAARGOS_257     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1874938..1886344
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J85_RS09370 (A6J85_09260) - 1875685..1876278 (-) 594 WP_008808724.1 class I SAM-dependent methyltransferase -
  A6J85_RS09375 (A6J85_09265) coaA 1876384..1877304 (+) 921 WP_105165144.1 type I pantothenate kinase -
  A6J85_RS09380 (A6J85_09270) rpsT 1877401..1877649 (+) 249 WP_008808726.1 30S ribosomal protein S20 -
  A6J85_RS09385 (A6J85_09275) - 1877714..1878223 (+) 510 WP_008808727.1 DNA topology modulation protein -
  A6J85_RS09390 (A6J85_09280) - 1878339..1879790 (+) 1452 WP_082307662.1 alpha-amylase -
  A6J85_RS09395 (A6J85_09285) ciaH 1879938..1881344 (-) 1407 WP_061599021.1 cell wall metabolism sensor histidine kinase WalK Regulator
  A6J85_RS09400 (A6J85_09290) ciaR 1881334..1882008 (-) 675 WP_008808730.1 response regulator transcription factor Regulator
  A6J85_RS09405 (A6J85_09295) - 1882138..1882554 (-) 417 WP_045634871.1 hypothetical protein -
  A6J85_RS09410 (A6J85_09300) - 1882738..1883541 (-) 804 WP_045634872.1 SDR family oxidoreductase -
  A6J85_RS09415 (A6J85_09305) - 1883556..1883882 (-) 327 WP_082307663.1 multidrug efflux SMR transporter -
  A6J85_RS09420 (A6J85_09310) - 1883933..1884217 (-) 285 WP_045502814.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 468 a.a.        Molecular weight: 53358.28 Da        Isoelectric Point: 8.8269

>NTDB_id=223207 A6J85_RS09395 WP_061599021.1 1879938..1881344(-) (ciaH) [Streptococcus gordonii strain FDAARGOS_257]
MLNKLRRTFYADDFSYFIRYFGVFTLIFSAMTLLIIQIMRSGLYTTVDDNLKSLSQNPRSVLHLALARAANMQPTIDEGQ
SSDDDTGPQDAPDPGPMDNLKVNSNTEAVLFDEDLKPLTTADHFLSLKKISIKKKDVGKIIQTTLKNNYGQEELYRMLVF
EINPSEFLSGNLLNKVKYAAVLINVNQLEQTSQNHEQIIVIVMISFWLISIIASIYLARVSVKPLIDSMQKQKSFVENAS
HELRTPLAVLQNRLETLFRKPEATIMESSENIASSLEEVRNMRMLTTNLLNLARRDDGIKAEITEVEPEFFTTTFANYEI
IADENEKVFIYENHIDHNIKTDRTLLKQLMTILFDNAVKYTEEDGVIKFIVWSKDRSLYLRVSDNGPGINNEDKKKIFDR
FYRVDKARTRQKGGFGLGLSLAKQIADALKGTITVKDNRPKGTIFEVKISIKSESKKRVGRLSDGKKD

Nucleotide


Download         Length: 1407 bp        

>NTDB_id=223207 A6J85_RS09395 WP_061599021.1 1879938..1881344(-) (ciaH) [Streptococcus gordonii strain FDAARGOS_257]
ATGCTGAATAAACTTAGACGAACTTTTTATGCGGATGATTTTTCATATTTCATTCGCTATTTTGGTGTATTCACACTTAT
TTTCTCGGCCATGACTCTTTTAATCATTCAGATTATGCGCTCAGGGCTTTATACAACAGTTGACGATAATTTAAAAAGTT
TAAGTCAGAATCCCAGATCTGTCCTCCACCTTGCTTTGGCTCGTGCAGCCAATATGCAACCAACGATTGATGAGGGTCAG
TCATCTGATGATGATACTGGGCCACAAGACGCCCCAGACCCTGGACCAATGGATAATCTGAAGGTGAATTCGAACACTGA
AGCAGTCTTGTTCGATGAAGACTTGAAACCATTGACTACTGCAGATCATTTTCTTAGTTTAAAAAAGATTTCAATCAAGA
AAAAGGATGTAGGTAAAATTATTCAGACTACTTTGAAAAACAACTATGGTCAAGAAGAACTCTATCGTATGTTGGTTTTT
GAGATTAATCCAAGCGAATTCTTATCTGGGAATCTTTTGAACAAAGTAAAATATGCAGCAGTTTTGATTAATGTCAATCA
ATTGGAGCAAACCAGTCAGAATCATGAACAAATCATTGTCATTGTTATGATTAGTTTCTGGTTAATTTCAATTATTGCCA
GTATTTATTTGGCTCGGGTCAGCGTGAAGCCTCTAATAGACAGTATGCAGAAGCAAAAATCTTTTGTTGAAAACGCCAGC
CATGAGTTGCGTACTCCTTTAGCTGTTTTGCAGAACCGTTTGGAAACTCTTTTCCGAAAACCGGAAGCTACGATTATGGA
ATCTAGTGAAAATATTGCCTCCAGTCTGGAAGAAGTTCGGAATATGCGGATGCTAACAACTAATCTATTGAATCTTGCAA
GAAGAGATGATGGCATTAAGGCTGAAATTACTGAAGTTGAACCAGAATTTTTCACTACAACATTTGCCAACTATGAAATC
ATTGCGGATGAAAATGAGAAAGTATTTATCTACGAAAATCATATCGACCACAACATCAAGACAGATAGAACACTTCTAAA
ACAGCTGATGACTATTCTCTTTGATAATGCTGTGAAATATACAGAAGAAGATGGGGTTATTAAGTTTATAGTATGGTCAA
AAGACCGTTCTCTATACTTACGAGTGTCCGATAACGGCCCTGGAATCAATAATGAAGACAAAAAGAAAATTTTTGATCGT
TTTTATAGGGTTGATAAGGCTAGAACAAGACAAAAGGGTGGTTTTGGTCTAGGTCTATCTCTTGCAAAACAAATAGCCGA
TGCTCTAAAGGGTACAATTACTGTTAAAGATAATAGACCTAAAGGTACCATTTTTGAAGTCAAAATTTCAATCAAATCAG
AAAGCAAGAAACGAGTTGGACGATTGAGTGATGGGAAAAAAGATTGA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(342-449)

His Kinase A (phospho-acceptor) domain (HisKA)

(233-298)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

65.721

97.863

0.643
  ciaH Streptococcus pneumoniae D39

65.721

97.863

0.643
  ciaH Streptococcus pneumoniae R6

65.721

97.863

0.643
  ciaH Streptococcus pneumoniae TIGR4

65.721

97.863

0.643
  ciaH Streptococcus mutans UA159

54.343

95.94

0.521

Multiple sequence alignment