Detailed information NTG0206181

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: BOC71_RS11345
• Genome accession: NZ_CP018137
• Coordinates: 2066439..2067191 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain SP61
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2061439..2072191

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BOC71_RS11315 (BOC71_02124)	-	2061818..2064370 (+)	2553	WP_000834680.1	YfhO family protein	-
BOC71_RS12785	-	2064400..2065547 (-)	1148	Protein_2049	YhgE/Pip family protein	-
BOC71_RS11330 (BOC71_02126)	-	2065654..2066196 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
BOC71_RS11345 (BOC71_02129)	comE	2066439..2067191 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
BOC71_RS11350 (BOC71_02130)	comD/comD1	2067188..2068513 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
BOC71_RS11355 (BOC71_02131)	comC/comC1	2068534..2068659 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
BOC71_RS11365 (BOC71_02133)	rlmH	2068941..2069420 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
BOC71_RS11370 (BOC71_02134)	htrA	2069603..2070784 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
BOC71_RS11375 (BOC71_02135)	spo0J	2070842..2071600 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=206181 BOC71_RS11345 WP_000866065.1 2066439..2067191(-) (comE) [Streptococcus pneumoniae strain SP61]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=206181 BOC71_RS11345 WP_000866065.1 2066439..2067191(-) (comE) [Streptococcus pneumoniae strain SP61]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408