Detailed information NTG0206105

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: BMJ42_RS12165
• Genome accession: NZ_CP018136
• Coordinates: 2201271..2202023 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain SP49
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2196271..2207023

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BMJ42_RS12140 (BMJ42_02306)	-	2196620..2199172 (+)	2553	WP_000834682.1	YfhO family protein	-
BMJ42_RS13790	-	2199202..2200379 (-)	1178	Protein_2232	YhgE/Pip family protein	-
BMJ42_RS12150 (BMJ42_02308)	-	2200486..2201028 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
BMJ42_RS12165 (BMJ42_02311)	comE	2201271..2202023 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
BMJ42_RS12170 (BMJ42_02312)	comD/comD1	2202020..2203345 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
BMJ42_RS12175 (BMJ42_02313)	comC/comC1	2203366..2203491 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
BMJ42_RS12185 (BMJ42_02315)	rlmH	2203773..2204252 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
BMJ42_RS12190 (BMJ42_02316)	htrA	2204435..2205616 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
BMJ42_RS12195 (BMJ42_02317)	spo0J	2205674..2206432 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=206105 BMJ42_RS12165 WP_000866065.1 2201271..2202023(-) (comE) [Streptococcus pneumoniae strain SP49]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=206105 BMJ42_RS12165 WP_000866065.1 2201271..2202023(-) (comE) [Streptococcus pneumoniae strain SP49]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408