Detailed information NTG0197419

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: WH25_RS06115
• Genome accession: NZ_CP017295
• Coordinates: 1274804..1275478 (+)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain IE35
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1269804..1280478

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WH25_RS06090 (WH25_06090)	-	1269829..1272372 (+)	2544	WP_046165640.1	M1 family metallopeptidase	-
WH25_RS06095 (WH25_06095)	-	1272555..1272839 (+)	285	WP_045502814.1	helix-turn-helix domain-containing protein	-
WH25_RS06100 (WH25_06100)	-	1272890..1273219 (+)	330	WP_081325075.1	DMT family transporter	-
WH25_RS06105 (WH25_06105)	-	1273231..1274034 (+)	804	WP_045634872.1	SDR family NAD(P)-dependent oxidoreductase	-
WH25_RS06110 (WH25_06110)	-	1274218..1274673 (+)	456	WP_046165638.1	hypothetical protein	-
WH25_RS06115 (WH25_06115)	ciaR	1274804..1275478 (+)	675	WP_008808730.1	response regulator transcription factor	Regulator
WH25_RS06120 (WH25_06120)	ciaH	1275468..1276874 (+)	1407	WP_046165637.1	sensor histidine kinase	Regulator
WH25_RS06125 (WH25_06125)	-	1277022..1278473 (-)	1452	WP_046165636.1	alpha-amylase	-
WH25_RS06130 (WH25_06130)	-	1278589..1279098 (-)	510	WP_046165635.1	DNA topology modulation protein	-
WH25_RS06135 (WH25_06135)	rpsT	1279163..1279411 (-)	249	WP_008808726.1	30S ribosomal protein S20	-
WH25_RS06140 (WH25_06140)	coaA	1279508..1280428 (-)	921	WP_045773980.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=197419 WH25_RS06115 WP_008808730.1 1274804..1275478(+) (ciaR) [Streptococcus gordonii strain IE35]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=197419 WH25_RS06115 WP_008808730.1 1274804..1275478(+) (ciaR) [Streptococcus gordonii strain IE35]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGACGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGGGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTGTCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362