Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   WH25_RS06120 Genome accession   NZ_CP017295
Coordinates   1275468..1276874 (+) Length   468 a.a.
NCBI ID   WP_046165637.1    Uniprot ID   -
Organism   Streptococcus gordonii strain IE35     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1270468..1281874
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WH25_RS06095 (WH25_06095) - 1272555..1272839 (+) 285 WP_045502814.1 helix-turn-helix domain-containing protein -
  WH25_RS06100 (WH25_06100) - 1272890..1273219 (+) 330 WP_081325075.1 DMT family transporter -
  WH25_RS06105 (WH25_06105) - 1273231..1274034 (+) 804 WP_045634872.1 SDR family NAD(P)-dependent oxidoreductase -
  WH25_RS06110 (WH25_06110) - 1274218..1274673 (+) 456 WP_046165638.1 hypothetical protein -
  WH25_RS06115 (WH25_06115) ciaR 1274804..1275478 (+) 675 WP_008808730.1 response regulator transcription factor Regulator
  WH25_RS06120 (WH25_06120) ciaH 1275468..1276874 (+) 1407 WP_046165637.1 sensor histidine kinase Regulator
  WH25_RS06125 (WH25_06125) - 1277022..1278473 (-) 1452 WP_046165636.1 alpha-amylase -
  WH25_RS06130 (WH25_06130) - 1278589..1279098 (-) 510 WP_046165635.1 DNA topology modulation protein -
  WH25_RS06135 (WH25_06135) rpsT 1279163..1279411 (-) 249 WP_008808726.1 30S ribosomal protein S20 -
  WH25_RS06140 (WH25_06140) coaA 1279508..1280428 (-) 921 WP_045773980.1 type I pantothenate kinase -
  WH25_RS06145 (WH25_06145) - 1280534..1281127 (+) 594 WP_046165634.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 468 a.a.        Molecular weight: 53311.23 Da        Isoelectric Point: 9.1193

>NTDB_id=197420 WH25_RS06120 WP_046165637.1 1275468..1276874(+) (ciaH) [Streptococcus gordonii strain IE35]
MLNKLRRTFYADDFSYFIRYFGVFTLIFSAMTLLIIQIMRSGLYTTVDDNLKSLSQNPRSVLHLALARAANMQPTIDEGQ
SSDDDTGPQDAPDPGPMDNLKVNSNTEAVLFDEDLKPLTTADHFLSLKKISIKKKDVGKIIQTTLKNNYGQEELYRMLVF
EINPSEFLSGNLLNKVKYAAVLINVNQLEQTSQNHEQIIVIVMISFWLISIIASIYLARVSVKPLIDSMQKQKSFVENAS
HELRTPLAVLQNRLETLFRKPEATIMESSENIASSLEEVRNMRMLTTNLLNLARRDDGIKPEIADVEPEFFTTTFANYEI
IADENEKAFVYENHINHNIKTDRTLLKQLMTILFDNAVKYTEEDGVIKFIVWSKDRSLYLRVSDNGPGINNEDKKKIFDR
FYRVDKARTRQKGGFGLGLSLAKQIADALKGTITVKDNRPKGTIFEIKISIKSESKKRVGRLSDGKKD

Nucleotide


Download         Length: 1407 bp        

>NTDB_id=197420 WH25_RS06120 WP_046165637.1 1275468..1276874(+) (ciaH) [Streptococcus gordonii strain IE35]
ATGCTGAATAAACTTAGACGAACTTTTTATGCGGATGATTTTTCATATTTCATTCGCTATTTTGGTGTATTCACACTTAT
TTTCTCGGCCATGACTCTTTTAATCATTCAGATTATGCGCTCAGGGCTTTATACAACAGTTGACGATAATTTAAAAAGTT
TAAGTCAGAATCCCAGATCTGTCCTCCACCTTGCTTTGGCTCGTGCAGCCAATATGCAACCAACGATTGATGAGGGTCAG
TCATCTGATGATGATACTGGGCCACAAGACGCCCCAGACCCTGGACCAATGGATAATCTGAAGGTGAATTCGAACACTGA
AGCAGTCTTGTTCGATGAAGACTTGAAACCATTGACTACTGCAGATCATTTTCTTAGTTTAAAAAAGATTTCAATCAAGA
AAAAGGATGTAGGTAAAATTATTCAGACTACTTTGAAAAACAACTATGGTCAAGAAGAACTCTATCGTATGTTGGTTTTT
GAAATTAATCCAAGTGAATTCTTATCTGGGAATCTTTTGAACAAAGTAAAATATGCAGCAGTTTTGATTAATGTCAATCA
ATTGGAGCAAACCAGTCAGAATCATGAACAGATTATTGTCATTGTTATGATTAGTTTTTGGTTAATCTCAATCATTGCCA
GTATCTATTTGGCTCGGGTCAGTGTGAAGCCTCTAATAGACAGTATGCAGAAGCAAAAATCTTTTGTTGAAAACGCCAGC
CATGAGTTGCGTACTCCTTTAGCTGTTTTGCAAAACCGTTTGGAAACTCTTTTCCGAAAACCGGAAGCTACGATTATGGA
ATCTAGTGAAAATATTGCCTCCAGTCTGGAAGAAGTTCGGAATATGCGGATGCTAACAACTAATCTATTGAATCTAGCAA
GAAGAGATGATGGCATTAAGCCTGAAATTGCTGATGTTGAACCAGAATTTTTCACTACAACATTTGCCAATTACGAAATC
ATTGCGGATGAAAACGAGAAAGCATTTGTCTACGAAAATCATATTAATCACAATATCAAGACAGATAGAACGCTTTTAAA
ACAGCTAATGACCATTCTCTTTGATAATGCTGTAAAATATACGGAAGAAGATGGGGTTATTAAGTTTATAGTATGGTCAA
AAGACCGTTCTCTTTACTTACGAGTGTCCGATAACGGTCCTGGAATCAATAATGAAGATAAGAAGAAAATTTTTGATCGC
TTTTATCGGGTCGATAAGGCTAGAACAAGACAAAAGGGTGGTTTTGGTCTAGGTCTATCCCTTGCAAAACAAATAGCCGA
TGCTCTAAAGGGTACAATTACTGTTAAAGATAATAGACCGAAAGGTACCATTTTTGAGATCAAAATTTCCATCAAATCAG
AAAGTAAGAAACGAGTTGGACGATTGAGTGATGGGAAAAAAGATTGA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(233-298)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(342-449)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

65.502

97.863

0.641
  ciaH Streptococcus pneumoniae D39

65.502

97.863

0.641
  ciaH Streptococcus pneumoniae R6

65.502

97.863

0.641
  ciaH Streptococcus pneumoniae TIGR4

65.502

97.863

0.641
  ciaH Streptococcus mutans UA159

54.343

95.94

0.521

Multiple sequence alignment