Detailed information NTG0183024

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLJM3_RS08265
• Genome accession: NZ_CP015901
• Coordinates: 1622686..1623378 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain JM3
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1617686..1628378

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLJM3_RS08245 (LLJM3_1621)	murD	1617840..1619189 (-)	1350	WP_011676627.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLJM3_RS08250 (LLJM3_1622)	-	1619358..1619699 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLJM3_RS08255 (LLJM3_1623)	-	1619781..1621022 (-)	1242	WP_011676629.1	ammonium transporter	-
LLJM3_RS08260 (LLJM3_1624)	covS	1621208..1622680 (-)	1473	WP_063284024.1	HAMP domain-containing histidine kinase	Regulator
LLJM3_RS08265 (LLJM3_1625)	covR	1622686..1623378 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLJM3_RS08270 (LLJM3_1626)	-	1623535..1624065 (-)	531	WP_011676632.1	DUF177 domain-containing protein	-
LLJM3_RS08275 (LLJM3_1627)	-	1624198..1624443 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLJM3_RS08280 (LLJM3_1628)	-	1624767..1625129 (-)	363	WP_011676634.1	TIGR02328 family protein	-
LLJM3_RS08285 (LLJM3_1629)	-	1625366..1626277 (-)	912	WP_011676635.1	CHAP domain-containing protein	-
LLJM3_RS08290 (LLJM3_1630)	-	1626370..1627206 (-)	837	WP_011834858.1	metallophosphoesterase	-
LLJM3_RS08295 (LLJM3_1631)	arsC	1627318..1627722 (-)	405	WP_011676637.1	arsenate reductase (thioredoxin)	-
LLJM3_RS08300 (LLJM3_03165)	-	1627914..1628051 (+)	138	Protein_1611	Ltp family lipoprotein	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=183024 LLJM3_RS08265 WP_011676631.1 1622686..1623378(-) (covR) [Lactococcus cremoris strain JM3]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=183024 LLJM3_RS08265 WP_011676631.1 1622686..1623378(-) (covR) [Lactococcus cremoris strain JM3]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361