Detailed information NTG0173334

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: A0O21_RS00740
• Genome accession: NZ_CP014699
• Coordinates: 148822..149556 (+)
• Length: 244 a.a.
• NCBI ID: WP_067060077.1
• Uniprot ID: A0A172Q5C5
• Organism: Streptococcus pantholopis strain TA 26
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 143822..154556

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A0O21_RS00715 (A0O21_00725)	-	143979..144407 (+)	429	WP_067060067.1	Msa family membrane protein	-
A0O21_RS00720 (A0O21_00730)	-	144400..145275 (+)	876	WP_067060069.1	ABC transporter ATP-binding protein	-
A0O21_RS00725 (A0O21_00735)	-	145280..146050 (+)	771	WP_067060071.1	hypothetical protein	-
A0O21_RS00730 (A0O21_00740)	-	146053..147768 (+)	1716	WP_099092230.1	ABC transporter ATP-binding protein	-
A0O21_RS00735 (A0O21_00745)	-	148299..148682 (-)	384	WP_067060075.1	hypothetical protein	-
A0O21_RS00740 (A0O21_00750)	comE/blpR	148822..149556 (+)	735	WP_067060077.1	response regulator transcription factor	Regulator
A0O21_RS00745 (A0O21_00755)	-	149560..150927 (+)	1368	WP_067060079.1	sensor histidine kinase	-
A0O21_RS00750 (A0O21_00760)	-	151597..152712 (-)	1116	WP_173644624.1	alpha/beta fold hydrolase	-
A0O21_RS00755 (A0O21_00765)	-	152764..153183 (-)	420	WP_067060081.1	helix-turn-helix domain-containing protein	-
A0O21_RS00760 (A0O21_00770)	rpsF	153414..153704 (+)	291	WP_067060083.1	30S ribosomal protein S6	-
A0O21_RS00765 (A0O21_00775)	ssb	153719..154222 (+)	504	WP_067060085.1	single-stranded DNA-binding protein	Machinery gene

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28386.49 Da
• Isoelectric Point: 6.2367

>NTDB_id=173334 A0O21_RS00740 WP_067060077.1 148822..149556(+) (comE/blpR) [Streptococcus pantholopis strain TA 26]
MLNIFILEDDYLQQTRLENIIKQSAASKNLKYRHLEIYGKPQQLLDAITEKGNHQLFFLDIEIKGEDQKGMEIAREIRLK
DPNAVIVFVSTHSEFMPVTYKYRVSALDFIDKGLPEEEFQEAIVSVLVHAYENMGRTVGEDAFIFKNKHSHVQVPFSDVL
FFETSTTVHKVILYTKTGQLEFYGKVSEIAKSDERLYQSHRAYVVNPENIVRIDRSNHMIYFEGDETCFVSKLKLKGLIE
RVEK

Nucleotide

• Length: 735 bp

>NTDB_id=173334 A0O21_RS00740 WP_067060077.1 148822..149556(+) (comE/blpR) [Streptococcus pantholopis strain TA 26]
ATGTTAAATATATTTATATTAGAGGATGACTATTTACAACAAACTCGTTTAGAAAATATCATTAAGCAAAGTGCTGCTTC
AAAAAATTTAAAGTACAGACATTTAGAAATATATGGGAAACCCCAACAACTGCTAGATGCAATTACTGAGAAAGGGAATC
ATCAGTTATTTTTTCTTGATATTGAAATCAAAGGGGAAGATCAAAAAGGAATGGAGATTGCTCGCGAAATTCGTTTAAAA
GATCCTAATGCTGTTATTGTTTTTGTGTCAACACATTCAGAATTTATGCCTGTAACCTATAAATACCGTGTTTCAGCACT
GGATTTCATTGATAAGGGACTGCCTGAAGAAGAATTTCAAGAAGCTATCGTTTCAGTATTGGTTCATGCTTATGAGAATA
TGGGGCGTACTGTCGGAGAAGATGCCTTTATCTTTAAGAATAAGCATTCACATGTTCAGGTTCCTTTTTCAGATGTCCTT
TTTTTTGAAACCTCAACAACTGTTCATAAGGTTATTCTCTACACAAAGACAGGGCAATTAGAATTTTATGGGAAAGTATC
CGAAATCGCTAAATCGGATGAACGACTATACCAAAGTCACCGTGCTTATGTAGTTAATCCTGAAAATATTGTCCGCATTG
ACCGGTCTAATCATATGATTTATTTTGAAGGTGATGAGACTTGTTTTGTCTCTAAGCTGAAACTAAAAGGGCTGATTGAA
AGAGTGGAGAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-241)

3D structure

• AlphaFold DB: A0A172Q5C5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.812	97.951	0.537
comE/comE1	Streptococcus equinus JB1	45.607	97.951	0.447
comE/comE2	Streptococcus equinus JB1	38.272	99.59	0.381
comE	Streptococcus pneumoniae Rx1	35.628	100	0.361
comE	Streptococcus pneumoniae D39	35.628	100	0.361
comE	Streptococcus pneumoniae R6	35.628	100	0.361
comE	Streptococcus pneumoniae TIGR4	35.628	100	0.361
comE	Streptococcus mitis SK321	35.628	100	0.361
comE	Streptococcus mitis NCTC 12261	35.628	100	0.361