Detailed information NTG0156105

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: RN86_RS08720
• Genome accession: NZ_CP012648
• Coordinates: 1796406..1797080 (-)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain KCOM 1506 (= ChDC B679)
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1791406..1802080

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RN86_RS08700 (RN86_08705)	rpsT	1792134..1792382 (+)	249	WP_008808726.1	30S ribosomal protein S20	-
RN86_RS08705 (RN86_08710)	-	1792613..1794064 (+)	1452	WP_053794628.1	alpha-amylase	-
RN86_RS08710 (RN86_08715)	-	1794088..1795014 (-)	927	WP_053794629.1	2-dehydropantoate 2-reductase N-terminal domain-containing protein	-
RN86_RS08715 (RN86_08720)	ciaH	1795016..1796416 (-)	1401	WP_053794630.1	HAMP domain-containing sensor histidine kinase	Regulator
RN86_RS08720 (RN86_08725)	ciaR	1796406..1797080 (-)	675	WP_008808730.1	response regulator transcription factor	Regulator
RN86_RS08725 (RN86_08730)	-	1797211..1797666 (-)	456	WP_053794631.1	hypothetical protein	-
RN86_RS08730 (RN86_08735)	-	1797878..1798420 (+)	543	WP_053794632.1	biotin transporter BioY	-
RN86_RS11630	-	1798568..1798831 (+)	264	Protein_1687	ISL3 family transposase	-
RN86_RS08735 (RN86_08740)	-	1798834..1799649 (-)	816	WP_053794633.1	SDR family NAD(P)-dependent oxidoreductase	-
RN86_RS08740 (RN86_08745)	-	1799653..1799979 (-)	327	WP_053794634.1	multidrug efflux SMR transporter	-
RN86_RS08745 (RN86_08750)	-	1800036..1800320 (-)	285	WP_002917391.1	helix-turn-helix transcriptional regulator	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=156105 RN86_RS08720 WP_008808730.1 1796406..1797080(-) (ciaR) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=156105 RN86_RS08720 WP_008808730.1 1796406..1797080(-) (ciaR) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGACGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGGGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTGTCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362