Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   CUGBS98_RS09655 Genome accession   NZ_CP010875
Coordinates   1918295..1919554 (-) Length   419 a.a.
NCBI ID   WP_001200975.1    Uniprot ID   A0AAV3JP75
Organism   Streptococcus agalactiae strain CU_GBS_98     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1916137..1956764 1918295..1919554 within 0


Gene organization within MGE regions


Location: 1916137..1956764
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CUGBS98_RS09645 (CUGBS98_01940) spx 1916468..1916866 (-) 399 WP_000591161.1 transcriptional regulator Spx -
  CUGBS98_RS09650 (CUGBS98_01941) recA 1917082..1918221 (-) 1140 WP_017647882.1 recombinase RecA Machinery gene
  CUGBS98_RS09655 (CUGBS98_01942) cinA 1918295..1919554 (-) 1260 WP_001200975.1 competence/damage-inducible protein A Machinery gene
  CUGBS98_RS09660 (CUGBS98_01943) - 1919643..1920194 (-) 552 WP_000817341.1 DNA-3-methyladenine glycosylase I -
  CUGBS98_RS09665 (CUGBS98_01944) ruvA 1920217..1920807 (-) 591 WP_000272490.1 Holliday junction branch migration protein RuvA -
  CUGBS98_RS09670 (CUGBS98_01945) - 1920809..1922041 (-) 1233 WP_000657472.1 MFS transporter -
  CUGBS98_RS09675 (CUGBS98_01946) mutL 1922073..1924046 (-) 1974 WP_000034614.1 DNA mismatch repair endonuclease MutL -
  CUGBS98_RS09680 (CUGBS98_01947) - 1924272..1924475 (+) 204 WP_000191849.1 cold shock domain-containing protein -
  CUGBS98_RS09685 (CUGBS98_01948) mutS 1924532..1927108 (-) 2577 WP_001118379.1 DNA mismatch repair protein MutS -
  CUGBS98_RS09690 (CUGBS98_01949) argR 1927165..1927602 (-) 438 WP_001033152.1 arginine repressor -
  CUGBS98_RS09695 (CUGBS98_01950) argS 1927824..1929515 (+) 1692 WP_000379864.1 arginine--tRNA ligase -
  CUGBS98_RS09700 (CUGBS98_01951) - 1929603..1929911 (+) 309 WP_001138859.1 bacteriocin immunity protein -
  CUGBS98_RS09705 (CUGBS98_01952) - 1929938..1930810 (-) 873 WP_000915478.1 YitT family protein -
  CUGBS98_RS09710 (CUGBS98_01953) - 1930918..1931862 (-) 945 WP_000857770.1 YitT family protein -
  CUGBS98_RS09715 (CUGBS98_01954) aspS 1931852..1933603 (-) 1752 WP_000830938.1 aspartate--tRNA ligase -
  CUGBS98_RS09720 (CUGBS98_01955) hisS 1933696..1934976 (-) 1281 WP_000775906.1 histidine--tRNA ligase -
  CUGBS98_RS09725 (CUGBS98_01956) rpmF 1935196..1935378 (+) 183 WP_000290414.1 50S ribosomal protein L32 -
  CUGBS98_RS09730 (CUGBS98_01957) rpmG 1935394..1935543 (+) 150 WP_001265622.1 50S ribosomal protein L33 -
  CUGBS98_RS09735 (CUGBS98_01958) - 1935824..1936285 (-) 462 WP_000852726.1 hypothetical protein -
  CUGBS98_RS09740 (CUGBS98_01959) - 1936290..1939160 (-) 2871 WP_017647881.1 SEC10/PgrA surface exclusion domain-containing protein -
  CUGBS98_RS09745 (CUGBS98_01960) xtgS 1939303..1939638 (+) 336 WP_000661406.1 XRE family transcriptional regulator XtgS -
  CUGBS98_RS09750 (CUGBS98_01961) - 1939675..1940631 (-) 957 WP_017647880.1 hypothetical protein -
  CUGBS98_RS09755 (CUGBS98_01962) - 1940866..1941159 (+) 294 WP_000458739.1 hypothetical protein -
  CUGBS98_RS09760 (CUGBS98_01963) - 1941241..1941681 (+) 441 WP_000190889.1 hypothetical protein -
  CUGBS98_RS09765 (CUGBS98_01964) - 1941678..1942208 (+) 531 WP_000614740.1 hypothetical protein -
  CUGBS98_RS09770 (CUGBS98_01965) - 1942208..1942954 (+) 747 WP_000027783.1 FtsK/SpoIIIE domain-containing protein -
  CUGBS98_RS09775 (CUGBS98_01966) - 1943118..1944389 (+) 1272 WP_017647879.1 replication protein RepA -
  CUGBS98_RS09780 (CUGBS98_01967) - 1944472..1944735 (+) 264 WP_000097743.1 MerR family transcriptional regulator -
  CUGBS98_RS09785 (CUGBS98_01968) - 1944832..1946097 (+) 1266 WP_001019353.1 site-specific integrase -
  CUGBS98_RS11150 - 1946302..1946487 (-) 186 WP_075316629.1 FanG protein -
  CUGBS98_RS09790 (CUGBS98_01969) - 1946516..1947130 (+) 615 WP_000615736.1 CadD family cadmium resistance transporter -
  CUGBS98_RS09795 (CUGBS98_01970) cadX 1947142..1947480 (+) 339 WP_000711079.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  CUGBS98_RS09800 (CUGBS98_01971) - 1947531..1948946 (+) 1416 WP_000667636.1 helix-turn-helix transcriptional regulator -
  CUGBS98_RS09805 (CUGBS98_01972) - 1949267..1949716 (+) 450 WP_000066889.1 sigma factor-like helix-turn-helix DNA-binding protein -
  CUGBS98_RS09810 (CUGBS98_01973) - 1949919..1950239 (+) 321 WP_000874694.1 hypothetical protein -
  CUGBS98_RS09815 (CUGBS98_01974) - 1950239..1951339 (+) 1101 WP_000203865.1 type IV secretion system DNA-binding domain-containing protein -
  CUGBS98_RS09820 (CUGBS98_01975) - 1951336..1951941 (+) 606 WP_000182709.1 hypothetical protein -
  CUGBS98_RS09825 (CUGBS98_01976) - 1952147..1952752 (+) 606 WP_001040935.1 replication protein -
  CUGBS98_RS09830 (CUGBS98_01977) - 1952745..1952993 (+) 249 WP_001058391.1 MerR family transcriptional regulator -
  CUGBS98_RS09835 (CUGBS98_01978) - 1953083..1953870 (+) 788 Protein_1893 site-specific integrase -
  CUGBS98_RS10725 - 1953907..1954712 (+) 806 WP_088181596.1 IS5-like element IS1381A family transposase -
  CUGBS98_RS09850 (CUGBS98_01981) - 1954729..1955199 (+) 471 Protein_1895 site-specific integrase -
  CUGBS98_RS09855 (CUGBS98_01982) - 1955558..1956229 (+) 672 WP_000186296.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 45454.24 Da        Isoelectric Point: 5.5601

>NTDB_id=140525 CUGBS98_RS09655 WP_001200975.1 1918295..1919554(-) (cinA) [Streptococcus agalactiae strain CU_GBS_98]
MRAEIIAVGTEILTGQIVNTNAQFLSEKMAELGIDIYFQTAVGDNEERLLSLLDIASQRSQLVILCGGLGPTEDDLTKQT
LAKFLGKSLTVDLLASQKLDRFFASRPQFARTPNNERQAQLVEGSIPLQNLTGLAVGGIVTSKGVQYMVLPGPPSELNPM
VMEQVVPILSNNGTKLYSRVLRFFGIGESQLVTILEDIIKNQTDPTIAPYAKVGEVTLRLSTKAENQDEADFKLDSLEKE
ILALKTLDNRKLKDLLYGYGDNNSMARTVLELLKVQNKTITAAESLTAGLFQSQLAEFSGASQVFNGGFTTYSMEAKSQL
LGIPKKKLQEYGVISHFTAEAMAQQARQLLKADFGIGLTGVAGPDELEGYPAGTVFIGIATPEGVSSIKVSIGGKSRSDV
RHISTLHAFDLVRRALLKI

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=140525 CUGBS98_RS09655 WP_001200975.1 1918295..1919554(-) (cinA) [Streptococcus agalactiae strain CU_GBS_98]
GTGAGGGCTGAAATTATCGCTGTAGGAACAGAAATTTTAACAGGACAGATCGTTAATACAAACGCACAATTTTTGTCGGA
GAAAATGGCAGAATTGGGAATTGATATTTATTTCCAGACAGCTGTAGGAGACAATGAGGAACGTTTATTATCGCTTTTAG
ATATAGCTAGTCAGCGCAGTCAATTGGTTATCCTATGTGGTGGACTTGGACCTACAGAGGATGATTTAACGAAACAAACT
TTGGCTAAATTTTTAGGTAAATCATTAACAGTGGATTTATTAGCTAGTCAAAAATTGGATCGTTTTTTTGCAAGTCGTCC
TCAGTTTGCTAGAACGCCAAATAATGAACGACAAGCTCAATTGGTTGAAGGCTCAATACCTCTACAAAACCTTACTGGTC
TAGCTGTTGGTGGTATCGTTACATCTAAGGGAGTCCAATATATGGTTTTACCAGGTCCGCCTAGTGAATTAAATCCAATG
GTTATGGAGCAGGTGGTACCTATTTTGTCAAATAATGGTACAAAATTATATTCACGTGTATTGAGATTCTTTGGTATCGG
TGAGAGTCAGTTAGTCACAATCTTAGAAGACATAATTAAGAATCAGACAGATCCAACTATAGCACCATATGCAAAGGTTG
GTGAGGTAACTTTAAGGTTATCAACGAAAGCTGAAAATCAGGATGAAGCCGACTTTAAATTAGATAGCTTAGAAAAAGAA
ATACTTGCTCTTAAGACATTAGATAACCGTAAATTAAAAGATTTATTATATGGTTATGGTGATAATAATAGTATGGCACG
TACTGTTTTAGAATTATTGAAAGTACAAAATAAAACGATTACTGCCGCAGAGAGCTTAACAGCAGGGTTATTTCAATCTC
AGTTAGCAGAATTTTCTGGTGCTTCGCAAGTTTTTAATGGTGGTTTTACGACCTATAGTATGGAAGCAAAATCACAACTT
CTCGGCATCCCTAAGAAAAAATTGCAAGAATATGGAGTTATCAGTCATTTTACAGCTGAGGCAATGGCTCAGCAAGCTCG
CCAACTTTTAAAAGCAGATTTTGGTATCGGTTTAACGGGAGTTGCTGGTCCTGATGAGTTGGAAGGATACCCTGCAGGTA
CAGTTTTTATTGGGATTGCAACCCCTGAAGGCGTTTCTTCTATTAAAGTATCGATTGGAGGGAAGAGCCGCTCAGATGTC
CGTCATATCAGTACTTTACATGCTTTTGACCTGGTGCGTAGGGCTTTATTAAAGATATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-241)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-415)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

71.223

99.523

0.709
  cinA Streptococcus mitis NCTC 12261

70.983

99.523

0.706
  cinA Streptococcus pneumoniae TIGR4

69.784

99.523

0.695
  cinA Streptococcus pneumoniae Rx1

69.784

99.523

0.695
  cinA Streptococcus pneumoniae R6

69.784

99.523

0.695
  cinA Streptococcus pneumoniae D39

69.544

99.523

0.692
  cinA Streptococcus mutans UA159

67.866

99.523

0.675
  cinA Streptococcus suis isolate S10

54.567

99.284

0.542
  cinA Bacillus subtilis subsp. subtilis str. 168

43.541

99.761

0.434

Multiple sequence alignment