Detailed information NTG0126432

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: NCDO2118_RS08445
• Genome accession: NZ_CP009054
• Coordinates: 1768336..1769028 (-)
• Length: 230 a.a.
• NCBI ID: WP_012898209.1
• Uniprot ID: A0AAW7IPJ0
• Organism: Lactococcus lactis subsp. lactis NCDO 2118
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1763336..1774028

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NCDO2118_RS08430 (NCDO2118_1634)	-	1764955..1765296 (-)	342	WP_012898206.1	P-II family nitrogen regulator	-
NCDO2118_RS08435 (NCDO2118_1635)	-	1765428..1766669 (-)	1242	WP_012898207.1	ammonium transporter	-
NCDO2118_RS08440 (NCDO2118_1636)	covS	1766852..1768327 (-)	1476	WP_012898208.1	HAMP domain-containing histidine kinase	Regulator
NCDO2118_RS08445 (NCDO2118_1637)	covR	1768336..1769028 (-)	693	WP_012898209.1	response regulator transcription factor	Regulator
NCDO2118_RS08450 (NCDO2118_1638)	-	1769184..1769714 (-)	531	WP_012898210.1	YceD family protein	-
NCDO2118_RS08455 (NCDO2118_1639)	-	1769845..1770090 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
NCDO2118_RS13770	-	1770246..1770443 (-)	198	WP_235187788.1	hypothetical protein	-
NCDO2118_RS13775	-	1770449..1770712 (-)	264	WP_235187789.1	hypothetical protein	-
NCDO2118_RS08465 (NCDO2118_1641)	-	1770794..1771156 (-)	363	WP_012898212.1	TIGR02328 family protein	-
NCDO2118_RS13580	-	1771373..1771519 (-)	147	WP_235187790.1	hypothetical protein	-
NCDO2118_RS08470 (NCDO2118_1642)	-	1771616..1772161 (-)	546	WP_235187791.1	metallophosphoesterase	-
NCDO2118_RS12970 (NCDO2118_1643)	-	1772446..1772697 (-)	252	WP_144242123.1	hypothetical protein	-
NCDO2118_RS12975	-	1772801..1772986 (-)	186	WP_235187792.1	DUF1211 domain-containing protein	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26670.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=126432 NCDO2118_RS08445 WP_012898209.1 1768336..1769028(-) (covR) [Lactococcus lactis subsp. lactis NCDO 2118]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEASSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=126432 NCDO2118_RS08445 WP_012898209.1 1768336..1769028(-) (covR) [Lactococcus lactis subsp. lactis NCDO 2118]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAAGTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCTCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

• Response regulator receiver domain (Response_reg) (6-115)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361