Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   C645_RS03020 Genome accession   NZ_CP008740
Coordinates   580843..582180 (-) Length   445 a.a.
NCBI ID   WP_005659796.1    Uniprot ID   -
Organism   Haemophilus influenzae 2019     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 575843..587180
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C645_RS02995 (C645_03050) - 577573..577845 (-) 273 WP_005630954.1 HU family DNA-binding protein -
  C645_RS03000 (C645_03055) - 577985..578575 (-) 591 WP_005656455.1 YjaG family protein -
  C645_RS03005 (C645_03060) nudC 578611..579405 (-) 795 WP_005656457.1 NAD(+) diphosphatase -
  C645_RS03010 (C645_03065) nfuA 579472..580068 (-) 597 WP_005656459.1 Fe-S biogenesis protein NfuA -
  C645_RS03015 (C645_03070) - 580144..580830 (-) 687 WP_005688731.1 ComF family protein -
  C645_RS03020 (C645_03075) comE 580843..582180 (-) 1338 WP_005659796.1 type IV pilus secretin PilQ family protein Machinery gene
  C645_RS03025 (C645_03080) comD 582190..582603 (-) 414 WP_011272047.1 pilus assembly protein PilP Machinery gene
  C645_RS03030 (C645_03085) comC 582600..583121 (-) 522 WP_046067623.1 competence protein ComC Machinery gene
  C645_RS03035 (C645_03090) comB 583118..583624 (-) 507 WP_005656467.1 competence protein ComB Machinery gene
  C645_RS03040 (C645_03095) comA 583625..584422 (-) 798 WP_005656469.1 pilus assembly protein PilM Machinery gene
  C645_RS03045 (C645_03100) - 584518..587112 (+) 2595 WP_005656471.1 penicillin-binding protein 1A -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49108.40 Da        Isoelectric Point: 7.4794

>NTDB_id=123954 C645_RS03020 WP_005659796.1 580843..582180(-) (comE) [Haemophilus influenzae 2019]
MKKYFLKCGCFLVFFCLPLIVFANPKTDNERFFIRLSQAPLAQTVEQLAFQQDVNLVIGDILESKISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGIYYLNGSQSGKGEVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPDGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=123954 C645_RS03020 WP_005659796.1 580843..582180(-) (comE) [Haemophilus influenzae 2019]
ATGAAGAAATATTTTTTAAAGTGCGGTTGTTTTTTAGTATTTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACAGTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATTGGAGATATATTGGAAAGCAAGATCTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGATTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TGAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCTTTAACAACAGGAAGTGGCTCTTTGCTTTCTCCCGATGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCTGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTCGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACATCGTGAGCAATACTCGTAACGATACGCAATCTGTGGAATTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCGCATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTGACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGCAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

97.978

100

0.98
  comE Haemophilus influenzae 86-028NP

96.629

100

0.966
  comE Glaesserella parasuis strain SC1401

52.204

96.854

0.506
  pilQ Vibrio campbellii strain DS40M4

41.844

95.056

0.398
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.505

92.584

0.384
  pilQ Vibrio cholerae strain A1552

41.505

92.584

0.384

Multiple sequence alignment