Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FE90_RS03525 Genome accession   NZ_CP008695
Coordinates   663639..664313 (+) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain M23ND     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 658639..669313
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FE90_RS03510 (FE90_0695) pstB 659072..659830 (+) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -
  FE90_RS03515 (FE90_0696) phoU 659898..660551 (+) 654 WP_038433368.1 phosphate signaling complex protein PhoU -
  FE90_RS03520 (FE90_0697) - 660756..663293 (+) 2538 WP_038433370.1 M1 family metallopeptidase -
  FE90_RS03525 (FE90_0698) ciaR 663639..664313 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  FE90_RS03530 (FE90_0699) ciaH 664306..665616 (+) 1311 WP_011054528.1 sensor histidine kinase Regulator
  FE90_RS03535 (FE90_0700) rpsT 665741..665989 (-) 249 WP_162472511.1 30S ribosomal protein S20 -
  FE90_RS03540 (FE90_0701) coaA 666043..666963 (-) 921 WP_002984525.1 type I pantothenate kinase -
  FE90_RS03545 (FE90_0702) - 667231..667785 (+) 555 WP_052153469.1 class I SAM-dependent methyltransferase -
  FE90_RS03550 (FE90_0703) - 667846..668841 (+) 996 WP_038433374.1 IS30-like element IS1239 family transposase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=123578 FE90_RS03525 WP_002984519.1 663639..664313(+) (ciaR) [Streptococcus pyogenes strain M23ND]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=123578 FE90_RS03525 WP_002984519.1 663639..664313(+) (ciaR) [Streptococcus pyogenes strain M23ND]
ATGATAAAGATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment