Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FE90_RS03530 Genome accession   NZ_CP008695
Coordinates   664306..665616 (+) Length   436 a.a.
NCBI ID   WP_011054528.1    Uniprot ID   A0A4U9BXV0
Organism   Streptococcus pyogenes strain M23ND     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 659306..670616
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FE90_RS03515 (FE90_0696) phoU 659898..660551 (+) 654 WP_038433368.1 phosphate signaling complex protein PhoU -
  FE90_RS03520 (FE90_0697) - 660756..663293 (+) 2538 WP_038433370.1 M1 family metallopeptidase -
  FE90_RS03525 (FE90_0698) ciaR 663639..664313 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  FE90_RS03530 (FE90_0699) ciaH 664306..665616 (+) 1311 WP_011054528.1 sensor histidine kinase Regulator
  FE90_RS03535 (FE90_0700) rpsT 665741..665989 (-) 249 WP_162472511.1 30S ribosomal protein S20 -
  FE90_RS03540 (FE90_0701) coaA 666043..666963 (-) 921 WP_002984525.1 type I pantothenate kinase -
  FE90_RS03545 (FE90_0702) - 667231..667785 (+) 555 WP_052153469.1 class I SAM-dependent methyltransferase -
  FE90_RS03550 (FE90_0703) - 667846..668841 (+) 996 WP_038433374.1 IS30-like element IS1239 family transposase -
  FE90_RS03555 (FE90_0704) - 668817..669479 (+) 663 Protein_689 BMP family lipoprotein -

Sequence

Protein


Download         Length: 436 a.a.        Molecular weight: 50112.66 Da        Isoelectric Point: 9.2692

>NTDB_id=123579 FE90_RS03530 WP_011054528.1 664306..665616(+) (ciaH) [Streptococcus pyogenes strain M23ND]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide


Download         Length: 1311 bp        

>NTDB_id=123579 FE90_RS03530 WP_011054528.1 664306..665616(+) (ciaH) [Streptococcus pyogenes strain M23ND]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(329-436)

His Kinase A (phospho-acceptor) domain (HisKA)

(220-285)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9BXV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

57.895

100

0.58
  ciaH Streptococcus pneumoniae Rx1

51.37

100

0.516
  ciaH Streptococcus pneumoniae D39

51.37

100

0.516
  ciaH Streptococcus pneumoniae R6

51.37

100

0.516
  ciaH Streptococcus pneumoniae TIGR4

51.37

100

0.516

Multiple sequence alignment