Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DK92_RS08285 Genome accession   NZ_CP007561
Coordinates   1707057..1708328 (-) Length   423 a.a.
NCBI ID   WP_047236047.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS596     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1697336..1725865 1707057..1708328 within 0


Gene organization within MGE regions


Location: 1697336..1725865
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK92_RS08235 (DK92_08475) nrdG 1697336..1697950 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  DK92_RS08240 (DK92_08480) - 1697950..1698459 (-) 510 WP_047236045.1 GNAT family N-acetyltransferase -
  DK92_RS08245 (DK92_08485) - 1698468..1699403 (-) 936 WP_047236046.1 Gfo/Idh/MocA family protein -
  DK92_RS09325 (DK92_08490) - 1699432..1699578 (-) 147 WP_002982210.1 hypothetical protein -
  DK92_RS08250 (DK92_08495) nrdD 1699760..1701958 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  DK92_RS08255 (DK92_08500) - 1702055..1703614 (-) 1560 WP_030126183.1 membrane protein -
  DK92_RS08260 (DK92_08510) - 1704027..1704332 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DK92_RS08265 (DK92_08515) ruvX 1704344..1704763 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DK92_RS08270 (DK92_08520) - 1704760..1705029 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DK92_RS08275 (DK92_08525) spx 1705143..1705541 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DK92_RS08280 (DK92_08530) recA 1705832..1706968 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  DK92_RS08285 (DK92_08535) cinA 1707057..1708328 (-) 1272 WP_047236047.1 competence/damage-inducible protein A Machinery gene
  DK92_RS08290 (DK92_08540) - 1708397..1708957 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  DK92_RS08295 (DK92_08545) ruvA 1708967..1709563 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  DK92_RS08300 (DK92_08550) - 1709565..1710785 (-) 1221 WP_047236048.1 MDR family MFS transporter -
  DK92_RS08305 (DK92_08555) mutL 1710796..1712778 (-) 1983 WP_047236089.1 DNA mismatch repair endonuclease MutL -
  DK92_RS08310 (DK92_08560) - 1712873..1714018 (-) 1146 WP_047236049.1 tyrosine-type recombinase/integrase -
  DK92_RS08315 (DK92_08565) dinD 1714275..1715129 (-) 855 WP_047236050.1 DNA damage-inducible protein D -
  DK92_RS09330 - 1715390..1715551 (-) 162 WP_168681587.1 hypothetical protein -
  DK92_RS08320 (DK92_08575) - 1715942..1716709 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator -
  DK92_RS08325 (DK92_08580) - 1716863..1717069 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  DK92_RS08335 (DK92_08585) - 1717103..1717870 (+) 768 WP_080343567.1 Bro-N domain-containing protein -
  DK92_RS08340 (DK92_08590) - 1717880..1718497 (+) 618 WP_047236051.1 Bro-N domain-containing protein -
  DK92_RS08345 (DK92_08595) - 1718524..1718766 (+) 243 WP_000648623.1 hypothetical protein -
  DK92_RS08350 (DK92_08600) - 1719023..1719355 (+) 333 WP_002992497.1 hypothetical protein -
  DK92_RS08355 (DK92_08605) - 1719355..1719546 (+) 192 WP_080032246.1 hypothetical protein -
  DK92_RS08360 (DK92_08610) - 1719558..1719920 (+) 363 WP_047236052.1 hypothetical protein -
  DK92_RS08365 (DK92_08615) - 1719917..1720225 (+) 309 WP_047236053.1 hypothetical protein -
  DK92_RS08370 (DK92_08620) - 1720228..1720500 (+) 273 WP_047236054.1 hypothetical protein -
  DK92_RS08375 (DK92_08625) - 1720501..1721367 (+) 867 WP_047236055.1 primase alpha helix C-terminal domain-containing protein -
  DK92_RS08380 (DK92_08630) - 1721379..1722772 (+) 1394 Protein_1600 VapE domain-containing protein -
  DK92_RS08385 (DK92_08635) - 1723066..1723320 (+) 255 WP_001069294.1 hypothetical protein -
  DK92_RS09125 - 1723317..1723490 (+) 174 WP_011285281.1 hypothetical protein -
  DK92_RS09335 - 1723496..1723669 (+) 174 WP_047236056.1 hypothetical protein -
  DK92_RS08400 (DK92_08650) - 1723671..1724180 (+) 510 WP_047236057.1 hypothetical protein -
  DK92_RS08405 (DK92_08655) - 1724254..1724742 (+) 489 WP_047236058.1 hypothetical protein -
  DK92_RS08410 (DK92_08660) - 1725145..1725507 (+) 363 WP_002992136.1 DUF1492 domain-containing protein -
  DK92_RS08415 (DK92_08665) - 1725482..1725865 (+) 384 WP_047236059.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45970.69 Da        Isoelectric Point: 4.8322

>NTDB_id=120913 DK92_RS08285 WP_047236047.1 1707057..1708328(-) (cinA) [Streptococcus pyogenes strain NGAS596]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=120913 DK92_RS08285 WP_047236047.1 1707057..1708328(-) (cinA) [Streptococcus pyogenes strain NGAS596]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATA
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment