Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DI45_RS09325 Genome accession   NZ_CP007560
Coordinates   1845486..1846757 (-) Length   423 a.a.
NCBI ID   WP_047235554.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS743     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1840486..1851757
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DI45_RS09290 (DI45_09625) - 1840899..1841204 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DI45_RS09295 (DI45_09630) ruvX 1841216..1841635 (-) 420 WP_012561069.1 Holliday junction resolvase RuvX -
  DI45_RS09300 (DI45_09635) - 1841632..1841901 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DI45_RS10145 (DI45_09645) - 1842111..1843480 (+) 1370 Protein_1792 IS1182 family transposase -
  DI45_RS09315 (DI45_09650) spx 1843572..1843970 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DI45_RS09320 (DI45_09655) recA 1844261..1845397 (-) 1137 WP_047235553.1 recombinase RecA Machinery gene
  DI45_RS09325 (DI45_09660) cinA 1845486..1846757 (-) 1272 WP_047235554.1 competence/damage-inducible protein A Machinery gene
  DI45_RS09330 (DI45_09665) - 1846826..1847386 (-) 561 WP_009880528.1 DNA-3-methyladenine glycosylase I -
  DI45_RS09335 (DI45_09670) ruvA 1847396..1847992 (-) 597 WP_011185063.1 Holliday junction branch migration protein RuvA -
  DI45_RS09340 (DI45_09675) - 1847994..1849214 (-) 1221 WP_002992187.1 MDR family MFS transporter -
  DI45_RS09345 (DI45_09680) mutL 1849225..1851207 (-) 1983 WP_009880530.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45917.61 Da        Isoelectric Point: 4.7648

>NTDB_id=120862 DI45_RS09325 WP_047235554.1 1845486..1846757(-) (cinA) [Streptococcus pyogenes strain NGAS743]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQSAGTVFIGLATQNKVESIKVLISGRSRLDV
CYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=120862 DI45_RS09325 WP_047235554.1 1845486..1846757(-) (cinA) [Streptococcus pyogenes strain NGAS743]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGTCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
TGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.031

100

0.69
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment