Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MMH06_RS04455 Genome accession   NZ_OV904788
Coordinates   849055..850311 (+) Length   418 a.a.
NCBI ID   WP_000642704.1    Uniprot ID   C1CTH7
Organism   Streptococcus pneumoniae strain RMV7 isolate RMV7domi     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 812377..852657 849055..850311 within 0


Gene organization within MGE regions


Location: 812377..852657
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MMH06_RS04255 (IONPJBJN_00837) ndk 813595..814008 (+) 414 WP_000438289.1 nucleoside-diphosphate kinase -
  MMH06_RS04260 (IONPJBJN_00839) - 814936..815568 (-) 633 WP_000571425.1 ABC transporter ATP-binding protein -
  MMH06_RS04265 (IONPJBJN_00840) - 815570..817585 (-) 2016 WP_000732395.1 DUF1430 domain-containing protein -
  MMH06_RS04270 (IONPJBJN_00841) - 818476..819693 (-) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  MMH06_RS04275 (IONPJBJN_00842) - 819775..819978 (-) 204 WP_000814511.1 excisionase -
  MMH06_RS04280 - 819962..820213 (+) 252 WP_001845478.1 hypothetical protein -
  MMH06_RS04285 (IONPJBJN_00843) - 820439..820669 (-) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  MMH06_RS04290 (IONPJBJN_00844) - 820666..821088 (-) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  MMH06_RS04295 (IONPJBJN_00845) - 821593..821946 (+) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  MMH06_RS04300 - 822006..822197 (-) 192 WP_001860868.1 cysteine-rich KTR domain-containing protein -
  MMH06_RS04305 (IONPJBJN_00846) - 822719..822889 (+) 171 WP_000873143.1 hypothetical protein -
  MMH06_RS04310 (IONPJBJN_00847) mef(A) 823275..824492 (+) 1218 WP_000417519.1 macrolide efflux MFS transporter Mef(A) -
  MMH06_RS04315 (IONPJBJN_00848) msr(D) 824612..826075 (+) 1464 WP_000420313.1 ABC-F type ribosomal protection protein Msr(D) -
  MMH06_RS04320 (IONPJBJN_00849) - 826193..826492 (-) 300 WP_001072467.1 DUF5960 family protein -
  MMH06_RS04325 (IONPJBJN_00850) - 826479..826847 (-) 369 WP_000567222.1 hypothetical protein -
  MMH06_RS04330 (IONPJBJN_00851) - 826860..827195 (-) 336 WP_000806926.1 hypothetical protein -
  MMH06_RS04335 (IONPJBJN_00852) - 827192..827437 (-) 246 WP_001813542.1 hypothetical protein -
  MMH06_RS04340 (IONPJBJN_00853) tet(M) 827801..829720 (-) 1920 WP_000691729.1 tetracycline resistance ribosomal protection protein Tet(M) -
  MMH06_RS04345 - 829736..829852 (-) 117 WP_001814923.1 tetracycline resistance determinant leader peptide -
  MMH06_RS04350 (IONPJBJN_00854) - 830097..831029 (-) 933 WP_001224318.1 conjugal transfer protein -
  MMH06_RS04355 (IONPJBJN_00855) - 831026..832027 (-) 1002 WP_000769868.1 bifunctional lysozyme/C40 family peptidase -
  MMH06_RS04360 (IONPJBJN_00856) - 832024..834201 (-) 2178 WP_001814875.1 membrane protein -
  MMH06_RS04365 (IONPJBJN_00857) - 834204..836651 (-) 2448 WP_000331160.1 ATP-binding protein -
  MMH06_RS04370 (IONPJBJN_00858) - 836635..837027 (-) 393 WP_000723888.1 conjugal transfer protein -
  MMH06_RS04375 (IONPJBJN_00859) - 837116..837613 (-) 498 WP_000342539.1 antirestriction protein ArdA -
  MMH06_RS04380 (IONPJBJN_00860) - 837730..837951 (-) 222 WP_001009056.1 hypothetical protein -
  MMH06_RS04385 (IONPJBJN_00861) - 838131..839378 (+) 1248 WP_000019067.1 ISL3 family transposase -
  MMH06_RS04390 (IONPJBJN_00863) erm(B) 839635..840372 (-) 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
  MMH06_RS04395 - 840497..840580 (-) 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
  MMH06_RS04400 - 840629..840841 (-) 213 WP_029645760.1 peptide-binding protein -
  MMH06_RS04405 (IONPJBJN_00864) mobT 840786..842048 (-) 1263 WP_001814870.1 MobT family relaxase -
  MMH06_RS04410 - 842071..842223 (-) 153 WP_000879507.1 hypothetical protein -
  MMH06_RS04415 (IONPJBJN_00865) - 842226..843611 (-) 1386 WP_000813494.1 FtsK/SpoIIIE domain-containing protein -
  MMH06_RS04420 (IONPJBJN_00866) - 843640..844026 (-) 387 WP_000985015.1 YdcP family protein -
  MMH06_RS04425 (IONPJBJN_00867) - 844042..844356 (-) 315 WP_000420682.1 YdcP family protein -
  MMH06_RS10905 (IONPJBJN_00868) - 844758..844928 (-) 171 WP_001227863.1 PhrA family quorum-sensing system peptide -
  MMH06_RS04430 (IONPJBJN_00869) - 845120..845983 (+) 864 WP_001093609.1 helix-turn-helix transcriptional regulator -
  MMH06_RS04435 (IONPJBJN_00870) comM 846289..846909 (+) 621 WP_000839909.1 hypothetical protein Regulator
  MMH06_RS04440 (IONPJBJN_00871) tsaE 846995..847438 (+) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  MMH06_RS04445 (IONPJBJN_00872) - 847428..847946 (+) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  MMH06_RS04450 (IONPJBJN_00873) - 847954..848970 (+) 1017 WP_000239278.1 LCP family protein -
  MMH06_RS04455 (IONPJBJN_00874) cinA 849055..850311 (+) 1257 WP_000642704.1 competence/damage-inducible protein A Machinery gene
  MMH06_RS04460 (IONPJBJN_00875) recA 850366..851532 (+) 1167 WP_001085462.1 recombinase RecA Machinery gene

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45089.42 Da        Isoelectric Point: 4.5211

>NTDB_id=1152097 MMH06_RS04455 WP_000642704.1 849055..850311(+) (cinA) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=1152097 MMH06_RS04455 WP_000642704.1 849055..850311(+) (cinA) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAACAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CTH7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae TIGR4

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.301

100

0.933
  cinA Streptococcus mitis NCTC 12261

93.062

100

0.931
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment