Detailed information NTG1144870

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLA12_RS08235
• Genome accession: NZ_LT599049
• Coordinates: 1723465..1724157 (-)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis subsp. lactis strain A12
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1718465..1729157

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLA12_RS08220 (LLA12_01753)	-	1720085..1720426 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
LLA12_RS08225 (LLA12_01754)	-	1720558..1721799 (-)	1242	WP_015426746.1	ammonium transporter	-
LLA12_RS08230 (LLA12_01755)	covS	1721982..1723457 (-)	1476	WP_021722681.1	HAMP domain-containing histidine kinase	Regulator
LLA12_RS08235 (LLA12_01756)	covR	1723465..1724157 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
LLA12_RS08240 (LLA12_01757)	-	1724313..1724843 (-)	531	WP_021722680.1	YceD family protein	-
LLA12_RS08245 (LLA12_01758)	-	1724974..1725219 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
LLA12_RS08250 (LLA12_01759)	-	1725375..1725839 (-)	465	WP_021722679.1	hypothetical protein	-
LLA12_RS08255 (LLA12_01760)	-	1725921..1726283 (-)	363	WP_010906050.1	TIGR02328 family protein	-
LLA12_RS14330 (LLA12_01761)	-	1726633..1726764 (-)	132	WP_021722678.1	hypothetical protein	-
LLA12_RS08265 (LLA12_01762)	-	1726768..1727298 (-)	531	WP_021722677.1	hypothetical protein	-
LLA12_RS08270 (LLA12_01763)	-	1727360..1728196 (-)	837	WP_032946821.1	metallophosphoesterase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=1144870 LLA12_RS08235 WP_003130756.1 1723465..1724157(-) (covR) [Lactococcus lactis subsp. lactis strain A12]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=1144870 LLA12_RS08235 WP_003130756.1 1723465..1724157(-) (covR) [Lactococcus lactis subsp. lactis strain A12]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCACGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361