Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   LLA12_RS08230 Genome accession   NZ_LT599049
Coordinates   1721982..1723457 (-) Length   491 a.a.
NCBI ID   WP_021722681.1    Uniprot ID   S6F7N1
Organism   Lactococcus lactis subsp. lactis strain A12     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1716982..1728457
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LLA12_RS08215 (LLA12_01752) murD 1718241..1719593 (-) 1353 WP_021722682.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -
  LLA12_RS08220 (LLA12_01753) - 1720085..1720426 (-) 342 WP_010906046.1 P-II family nitrogen regulator -
  LLA12_RS08225 (LLA12_01754) - 1720558..1721799 (-) 1242 WP_015426746.1 ammonium transporter -
  LLA12_RS08230 (LLA12_01755) covS 1721982..1723457 (-) 1476 WP_021722681.1 HAMP domain-containing histidine kinase Regulator
  LLA12_RS08235 (LLA12_01756) covR 1723465..1724157 (-) 693 WP_003130756.1 response regulator transcription factor Regulator
  LLA12_RS08240 (LLA12_01757) - 1724313..1724843 (-) 531 WP_021722680.1 YceD family protein -
  LLA12_RS08245 (LLA12_01758) - 1724974..1725219 (-) 246 WP_003130760.1 type B 50S ribosomal protein L31 -
  LLA12_RS08250 (LLA12_01759) - 1725375..1725839 (-) 465 WP_021722679.1 hypothetical protein -
  LLA12_RS08255 (LLA12_01760) - 1725921..1726283 (-) 363 WP_010906050.1 TIGR02328 family protein -
  LLA12_RS14330 (LLA12_01761) - 1726633..1726764 (-) 132 WP_021722678.1 hypothetical protein -
  LLA12_RS08265 (LLA12_01762) - 1726768..1727298 (-) 531 WP_021722677.1 hypothetical protein -
  LLA12_RS08270 (LLA12_01763) - 1727360..1728196 (-) 837 WP_032946821.1 metallophosphoesterase -

Sequence

Protein


Download         Length: 491 a.a.        Molecular weight: 56209.15 Da        Isoelectric Point: 4.8756

>NTDB_id=1144869 LLA12_RS08230 WP_021722681.1 1721982..1723457(-) (covS) [Lactococcus lactis subsp. lactis strain A12]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYKDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Nucleotide


Download         Length: 1476 bp        

>NTDB_id=1144869 LLA12_RS08230 WP_021722681.1 1721982..1723457(-) (covS) [Lactococcus lactis subsp. lactis strain A12]
ATGAAAAAATTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATAAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCGAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAAAGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGCCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGTTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Domains

Predicted by InterproScan.

ArlS sensor domain (ArlS_N)

(54-185)

HAMP domain (HAMP)

(208-257)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(380-489)

His Kinase A (phospho-acceptor) domain (HisKA)

(267-332)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB S6F7N1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Lactococcus lactis subsp. lactis strain DGCC12653

99.796

100

0.998

Multiple sequence alignment