Detailed information NTG1142940

Bioinformatically predicted

Overview

• Name: comGA/cglA/cilD
• Type: Machinery gene
• Locus tag: DQL00_RS03745
• Genome accession: NZ_LS483523
• Coordinates: 708565..709506 (+)
• Length: 313 a.a.
• NCBI ID: WP_000249564.1
• Uniprot ID: Q8DN86
• Organism: Streptococcus pneumoniae strain 4041STDY6836169
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	706598..707893	708565..709506	flank	672

Gene organization within MGE regions

Location: 706598..709506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL00_RS03740	-	708124..708489 (+)	366	WP_023396479.1	DUF1033 family protein	-
DQL00_RS03745	comGA/cglA/cilD	708565..709506 (+)	942	WP_000249564.1	competence type IV pilus ATPase ComGA	Machinery gene

Sequence

Protein

• Length: 313 a.a.
• Molecular weight: 35555.47 Da
• Isoelectric Point: 6.1330

>NTDB_id=1142940 DQL00_RS03745 WP_000249564.1 708565..709506(+) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 4041STDY6836169]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDHKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide

• Length: 942 bp

>NTDB_id=1142940 DQL00_RS03745 WP_000249564.1 708565..709506(+) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATCTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCATAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACCTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

• Type II/IV secretion system protein (T2SSE) (9-266)

3D structure

• AlphaFold DB: Q8DN86

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGA/cglA/cilD	Streptococcus pneumoniae Rx1	100	100	1
comGA/cglA/cilD	Streptococcus pneumoniae D39	100	100	1
comGA/cglA/cilD	Streptococcus pneumoniae R6	100	100	1
comGA/cglA/cilD	Streptococcus pneumoniae TIGR4	100	100	1
comGA/cglA/cilD	Streptococcus mitis NCTC 12261	95.847	100	0.958
comYA	Streptococcus gordonii str. Challis substr. CH1	78.065	99.042	0.773
comYA	Streptococcus mutans UA159	65.916	99.361	0.655
comYA	Streptococcus mutans UA140	65.916	99.361	0.655
comGA/cglA	Streptococcus sobrinus strain NIDR 6715-7	62.581	99.042	0.62
comGA	Lactococcus lactis subsp. cremoris KW2	54.808	99.681	0.546
comGA	Latilactobacillus sakei subsp. sakei 23K	41.912	86.901	0.364