Detailed information NTG1142052

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: DQL01_RS05020
• Genome accession: NZ_LS483451
• Coordinates: 931813..932463 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387337.1
• Uniprot ID: A0A064BX47
• Organism: Streptococcus pneumoniae strain 4041STDY6836166
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 926813..937463

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL01_RS04975	-	927296..927511 (+)	216	WP_001232085.1	YozE family protein	-
DQL01_RS04980	-	927597..928565 (+)	969	WP_050090562.1	PhoH family protein	-
DQL01_RS04990	-	928758..929258 (+)	501	WP_111702535.1	GNAT family N-acetyltransferase	-
DQL01_RS04995	-	929261..929587 (+)	327	Protein_948	TfoX/Sxy family protein	-
DQL01_RS12375	ald	929888..930999 (-)	1112	Protein_949	alanine dehydrogenase	-
DQL01_RS05015	-	931176..931745 (+)	570	WP_001864145.1	GNAT family N-acetyltransferase	-
DQL01_RS05020	comEA/celA/cilE	931813..932463 (+)	651	WP_000387337.1	helix-hairpin-helix domain-containing protein	Machinery gene
DQL01_RS05025	comEC/celB	932447..934687 (+)	2241	WP_111702537.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
DQL01_RS05030	-	934866..935054 (+)	189	WP_010976492.1	hypothetical protein	-
DQL01_RS05035	-	935087..935674 (+)	588	WP_054378649.1	ATP-binding cassette domain-containing protein	-
DQL01_RS05040	-	935678..936862 (+)	1185	WP_111702538.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23191.51 Da
• Isoelectric Point: 5.5171

>NTDB_id=1142052 DQL01_RS05020 WP_000387337.1 931813..932463(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 4041STDY6836166]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=1142052 DQL01_RS05020 WP_000387337.1 931813..932463(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 4041STDY6836166]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTCAAAGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A064BX47

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	98.148	100	0.981
comEA/celA/cilE	Streptococcus pneumoniae D39	98.148	100	0.981
comEA/celA/cilE	Streptococcus pneumoniae R6	98.148	100	0.981
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.222	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis SK321	92.13	100	0.921
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Latilactobacillus sakei subsp. sakei 23K	33.906	100	0.366
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366