Detailed information NTG1141947

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DQK98_RS11195
• Genome accession: NZ_LS483449
• Coordinates: 2099263..2100015 (-)
• Length: 250 a.a.
• NCBI ID: WP_111688199.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 4041STDY6836170
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2094263..2105015

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQK98_RS12285	-	2096612..2098299 (-)	1688	Protein_2064	YhgE/Pip family protein	-
DQK98_RS11180	-	2098478..2099020 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
DQK98_RS11195	comE	2099263..2100015 (-)	753	WP_111688199.1	competence system response regulator transcription factor ComE	Regulator
DQK98_RS11200	comD/comD1	2100012..2101337 (-)	1326	WP_033705078.1	competence system sensor histidine kinase ComD	Regulator
DQK98_RS11205	comC/comC1	2101358..2101483 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
DQK98_RS11215	rlmH	2101765..2102244 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQK98_RS11220	htrA	2102427..2103608 (+)	1182	WP_050155297.1	S1C family serine protease	Regulator
DQK98_RS11225	spo0J	2103666..2104424 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29986.37 Da
• Isoelectric Point: 6.7051

>NTDB_id=1141947 DQK98_RS11195 WP_111688199.1 2099263..2100015(-) (comE) [Streptococcus pneumoniae strain 4041STDY6836170]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNRLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1141947 DQK98_RS11195 WP_111688199.1 2099263..2100015(-) (comE) [Streptococcus pneumoniae strain 4041STDY6836170]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCGGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98	100	0.98
comE	Streptococcus infantis strain Atu-4	90.8	100	0.908
comE/comE2	Streptococcus gordonii strain NCTC7865	62.4	100	0.624
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.4	100	0.624
comE/blpR	Streptococcus mutans UA159	40.891	98.8	0.404