Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQN23_RS08535 Genome accession   NZ_LS483403
Coordinates   1700440..1701699 (-) Length   419 a.a.
NCBI ID   WP_111713037.1    Uniprot ID   -
Organism   Streptococcus lutetiensis strain NCTC13774     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1690379..1758588 1700440..1701699 within 0


Gene organization within MGE regions


Location: 1690379..1758588
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN23_RS08485 (NCTC13774_01776) - 1690568..1691179 (+) 612 WP_020917586.1 TetR/AcrR family transcriptional regulator -
  DQN23_RS08490 (NCTC13774_01777) nrdG 1691728..1692342 (-) 615 WP_020917588.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  DQN23_RS08495 (NCTC13774_01778) - 1692383..1692889 (-) 507 WP_020917589.1 GNAT family N-acetyltransferase -
  DQN23_RS09110 (NCTC13774_01779) - 1692901..1693047 (-) 147 WP_006531408.1 hypothetical protein -
  DQN23_RS08500 (NCTC13774_01780) nrdD 1693164..1695389 (-) 2226 WP_058832874.1 anaerobic ribonucleoside-triphosphate reductase -
  DQN23_RS08505 (NCTC13774_01781) - 1695490..1697064 (-) 1575 WP_111713034.1 DUF2079 domain-containing protein -
  DQN23_RS09545 (NCTC13774_01782) - 1697107..1697235 (-) 129 WP_260665378.1 hypothetical protein -
  DQN23_RS08510 (NCTC13774_01783) - 1697361..1697678 (-) 318 WP_111713035.1 DUF1292 domain-containing protein -
  DQN23_RS08515 (NCTC13774_01784) ruvX 1697711..1698130 (-) 420 WP_111713036.1 Holliday junction resolvase RuvX -
  DQN23_RS08520 (NCTC13774_01785) - 1698127..1698396 (-) 270 WP_003066890.1 IreB family regulatory phosphoprotein -
  DQN23_RS08525 (NCTC13774_01786) spx 1698643..1699041 (-) 399 WP_004233512.1 transcriptional regulator Spx -
  DQN23_RS08530 (NCTC13774_01787) recA 1699239..1700393 (-) 1155 WP_020917594.1 recombinase RecA Machinery gene
  DQN23_RS08535 (NCTC13774_01788) cinA 1700440..1701699 (-) 1260 WP_111713037.1 competence/damage-inducible protein A Machinery gene
  DQN23_RS09480 - 1701996..1702148 (-) 153 WP_233422881.1 hypothetical protein -
  DQN23_RS09485 (NCTC13774_01789) - 1702174..1702401 (-) 228 WP_233422882.1 MFS transporter -
  DQN23_RS08545 (NCTC13774_01790) - 1702602..1703153 (-) 552 WP_058814328.1 DNA-3-methyladenine glycosylase I -
  DQN23_RS08550 (NCTC13774_01791) ruvA 1703183..1703776 (-) 594 WP_020917597.1 Holliday junction branch migration protein RuvA -
  DQN23_RS08555 (NCTC13774_01792) mutL 1703777..1705717 (-) 1941 WP_020917598.1 DNA mismatch repair endonuclease MutL -
  DQN23_RS08560 (NCTC13774_01793) mutS 1705837..1708404 (-) 2568 WP_058814330.1 DNA mismatch repair protein MutS -
  DQN23_RS08565 (NCTC13774_01794) - 1708391..1708744 (-) 354 WP_020917600.1 YlbF family regulator -
  DQN23_RS08570 (NCTC13774_01795) argR 1708741..1709178 (-) 438 WP_020917601.1 arginine repressor -
  DQN23_RS08575 (NCTC13774_01796) argS 1709368..1711059 (+) 1692 WP_111713039.1 arginine--tRNA ligase -
  DQN23_RS08580 (NCTC13774_01797) - 1711107..1712525 (-) 1419 WP_111699143.1 prolyl oligopeptidase family serine peptidase -
  DQN23_RS08585 (NCTC13774_01798) - 1712629..1713495 (-) 867 WP_111713040.1 YitT family protein -
  DQN23_RS08590 (NCTC13774_01799) - 1713540..1714478 (-) 939 WP_020917605.1 YitT family protein -
  DQN23_RS08595 (NCTC13774_01800) aspS 1714471..1716219 (-) 1749 WP_020917606.1 aspartate--tRNA ligase -
  DQN23_RS08600 (NCTC13774_01801) hisS 1716375..1717652 (-) 1278 WP_111713041.1 histidine--tRNA ligase -
  DQN23_RS08605 (NCTC13774_01802) rpmF 1717941..1718117 (+) 177 WP_003066947.1 50S ribosomal protein L32 -
  DQN23_RS08610 (NCTC13774_01803) rpmG 1718133..1718282 (+) 150 WP_002262412.1 50S ribosomal protein L33 -
  DQN23_RS08615 (NCTC13774_01804) - 1718429..1719811 (+) 1383 WP_111713042.1 hypothetical protein -
  DQN23_RS08620 (NCTC13774_01805) - 1719898..1721394 (-) 1497 WP_111713043.1 site-specific integrase -
  DQN23_RS08625 (NCTC13774_01806) - 1721410..1721658 (-) 249 WP_111713044.1 hypothetical protein -
  DQN23_RS08630 (NCTC13774_01807) - 1721645..1722559 (-) 915 WP_233422883.1 FtsK/SpoIIIE domain-containing protein -
  DQN23_RS08635 (NCTC13774_01808) - 1722510..1722761 (-) 252 WP_111713045.1 hypothetical protein -
  DQN23_RS08640 (NCTC13774_01809) - 1722819..1723139 (-) 321 WP_111713046.1 hypothetical protein -
  DQN23_RS08645 (NCTC13774_01810) - 1723335..1723841 (-) 507 WP_111713047.1 hypothetical protein -
  DQN23_RS08650 (NCTC13774_01811) - 1724462..1724983 (-) 522 WP_111713096.1 ClbS/DfsB family four-helix bundle protein -
  DQN23_RS08655 (NCTC13774_01812) - 1725081..1726565 (-) 1485 WP_111713048.1 site-specific integrase -
  DQN23_RS08660 (NCTC13774_01813) - 1726575..1726823 (-) 249 WP_111713049.1 hypothetical protein -
  DQN23_RS08665 (NCTC13774_01814) - 1726891..1727919 (-) 1029 WP_020917611.1 replication initiation factor domain-containing protein -
  DQN23_RS08670 (NCTC13774_01815) - 1727922..1728353 (-) 432 WP_000159997.1 hypothetical protein -
  DQN23_RS09615 - 1728398..1728631 (-) 234 WP_043895152.1 hypothetical protein -
  DQN23_RS09490 - 1728628..1729082 (-) 455 Protein_1670 hypothetical protein -
  DQN23_RS08685 (NCTC13774_01817) - 1729082..1729297 (-) 216 WP_111713050.1 hypothetical protein -
  DQN23_RS08690 (NCTC13774_01818) - 1729619..1730539 (+) 921 WP_020917613.1 helix-turn-helix domain-containing protein -
  DQN23_RS09620 - 1730560..1731677 (+) 1118 Protein_1673 Fic family protein -
  DQN23_RS08700 (NCTC13774_01820) - 1731860..1732669 (+) 810 WP_020917614.1 hypothetical protein -
  DQN23_RS08710 (NCTC13774_01822) - 1733609..1734490 (-) 882 WP_111713051.1 diacylglycerol kinase family protein -
  DQN23_RS08715 (NCTC13774_01823) - 1734567..1735619 (-) 1053 WP_020917615.1 TIGR00341 family protein -
  DQN23_RS08720 (NCTC13774_01824) - 1735662..1736033 (-) 372 WP_111713052.1 hypothetical protein -
  DQN23_RS08725 (NCTC13774_01826) - 1736732..1736971 (+) 240 WP_020917618.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  DQN23_RS08730 (NCTC13774_01827) amaP 1737033..1737599 (+) 567 WP_111713097.1 alkaline shock response membrane anchor protein AmaP -
  DQN23_RS08735 (NCTC13774_01828) - 1737611..1737781 (+) 171 WP_020917620.1 DUF2273 domain-containing protein -
  DQN23_RS08740 (NCTC13774_01829) - 1737796..1738356 (+) 561 WP_020917621.1 Asp23/Gls24 family envelope stress response protein -
  DQN23_RS08745 (NCTC13774_01830) - 1738440..1738643 (+) 204 WP_020917622.1 CsbD family protein -
  DQN23_RS08750 - 1738846..1740197 (-) 1352 Protein_1683 IS3 family transposase -
  DQN23_RS08755 (NCTC13774_01834) - 1740276..1740629 (-) 354 WP_111713053.1 DUF1304 domain-containing protein -
  DQN23_RS08760 (NCTC13774_01835) - 1740849..1743176 (-) 2328 WP_111713054.1 YhgE/Pip domain-containing protein -
  DQN23_RS08765 (NCTC13774_01836) - 1743308..1743844 (+) 537 WP_171009913.1 TetR/AcrR family transcriptional regulator -
  DQN23_RS09505 - 1743949..1744513 (-) 565 Protein_1687 IS3 family transposase -
  DQN23_RS08775 (NCTC13774_01838) rpsD 1744652..1745263 (-) 612 WP_004233633.1 30S ribosomal protein S4 -
  DQN23_RS08780 (NCTC13774_01839) - 1745520..1745792 (-) 273 WP_004233634.1 Veg family protein -
  DQN23_RS08785 (NCTC13774_01840) dnaB 1745817..1747178 (-) 1362 WP_111713055.1 replicative DNA helicase -
  DQN23_RS08790 (NCTC13774_01841) rplI 1747212..1747664 (-) 453 WP_058814338.1 50S ribosomal protein L9 -
  DQN23_RS08795 (NCTC13774_01842) - 1747661..1749640 (-) 1980 WP_058832890.1 DHH family phosphoesterase -
  DQN23_RS08800 (NCTC13774_01843) mnmG 1749750..1751654 (-) 1905 WP_058832891.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
  DQN23_RS08805 (NCTC13774_01844) mnmA 1751963..1753084 (-) 1122 WP_111713056.1 tRNA 2-thiouridine(34) synthase MnmA -
  DQN23_RS08810 (NCTC13774_01845) sdaAB 1753343..1754014 (+) 672 WP_039696101.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -
  DQN23_RS08815 (NCTC13774_01846) sdaAA 1754026..1754898 (+) 873 WP_020917633.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  DQN23_RS08820 (NCTC13774_01847) - 1754987..1755622 (+) 636 WP_020917634.1 HAD hydrolase-like protein -
  DQN23_RS08825 (NCTC13774_01848) - 1755651..1756319 (-) 669 WP_111713057.1 transglycosylase SLT domain-containing protein -
  DQN23_RS08830 (NCTC13774_01849) - 1756572..1757171 (-) 600 WP_020917636.1 LysM domain-containing protein -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 45911.31 Da        Isoelectric Point: 5.3330

>NTDB_id=1140371 DQN23_RS08535 WP_111713037.1 1700440..1701699(-) (cinA) [Streptococcus lutetiensis strain NCTC13774]
MKAEIIAVGTEILTGQITNTNAQFLSEEFAKLGIDVFFQTAVGDNEERLLSIIDLANKRSDLVVLCGGLGPTEDDLTKQT
LAKYLGRNLVFDEQASKRLNEFFATRPQFTRTANNERQAQLIEGSTPLQNSTGLAVGGVIEVDGVTYVVLPGPPSELKPM
VWDYLVPLLSSDHKQLYSRVLRFFGIGESQLVTVLSDLIDNQTDPTIAPYAKTGEVTLRLSTKADDIESAKEKLDQLEQK
ILSKKTLNSIPLENLLYGYGDDNSMARVVFDLLKKKHKTITAAESLTAGLFQSSIADFSGSSSVFNGGFVTYSIEEKSKM
LQIPLEKLQEHGVVSHFTAEKMAEQSRKLTDADFGIGLTGVAGPDSLEGHPAGTVFIGIATREKVHSIRVLIGGRRRSDV
RHIACLYAFNLVRQALLQD

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=1140371 DQN23_RS08535 WP_111713037.1 1700440..1701699(-) (cinA) [Streptococcus lutetiensis strain NCTC13774]
ATGAAAGCTGAGATTATCGCTGTAGGAACAGAGATTTTAACAGGACAAATCACAAATACCAATGCGCAATTTTTATCTGA
AGAATTTGCCAAGTTAGGGATTGATGTTTTTTTCCAAACAGCTGTTGGGGACAATGAAGAGCGTCTTTTGTCTATCATTG
ATTTGGCAAATAAGCGTAGCGATTTAGTTGTTCTCTGTGGTGGTTTAGGACCAACTGAGGATGATTTGACAAAGCAAACC
TTAGCAAAATATTTAGGGCGTAACCTGGTCTTTGATGAACAGGCAAGTAAACGTCTAAATGAGTTCTTTGCGACACGTCC
TCAATTTACAAGAACAGCTAACAATGAACGCCAAGCTCAACTGATTGAAGGTTCAACTCCTTTGCAAAATAGCACTGGTT
TGGCTGTAGGTGGAGTGATTGAAGTTGACGGCGTCACTTATGTTGTTCTTCCTGGCCCACCAAGTGAGCTTAAGCCCATG
GTCTGGGATTATTTAGTGCCTTTGTTATCTAGCGACCATAAGCAACTTTATTCACGTGTTTTGCGTTTCTTTGGCATTGG
AGAAAGCCAACTGGTAACTGTTTTATCAGATTTGATTGACAACCAAACTGATCCAACCATTGCGCCATATGCTAAGACAG
GTGAAGTAACGCTGCGTTTGTCAACGAAAGCAGACGACATTGAATCAGCTAAGGAAAAACTAGACCAGCTAGAGCAAAAA
ATTCTTTCTAAGAAGACTTTAAATAGCATTCCGCTTGAGAATTTGCTTTATGGTTACGGTGATGACAATAGTATGGCGCG
TGTTGTTTTTGATTTGCTTAAGAAAAAACACAAGACCATTACAGCTGCAGAAAGTTTAACAGCAGGGCTGTTTCAATCAA
GTATTGCAGACTTCTCAGGCTCTTCATCAGTCTTTAATGGTGGTTTTGTGACTTATAGCATTGAAGAAAAATCAAAAATG
CTTCAGATTCCATTAGAAAAGTTGCAAGAACACGGGGTTGTTAGTCACTTTACAGCTGAGAAAATGGCTGAGCAATCTCG
CAAGTTAACAGATGCTGATTTTGGGATTGGATTGACAGGAGTTGCAGGACCAGATAGCTTAGAAGGTCACCCAGCAGGAA
CAGTTTTCATTGGTATTGCTACTAGAGAAAAAGTTCATTCTATTCGTGTTCTCATAGGTGGACGAAGACGTTCAGACGTG
CGTCATATTGCATGTTTGTATGCTTTTAACTTGGTACGTCAAGCTTTATTACAGGATTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-415)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-242)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

71.703

99.523

0.714
  cinA Streptococcus mitis SK321

71.36

100

0.714
  cinA Streptococcus mitis NCTC 12261

70.406

100

0.704
  cinA Streptococcus pneumoniae Rx1

69.451

100

0.695
  cinA Streptococcus pneumoniae TIGR4

69.451

100

0.695
  cinA Streptococcus pneumoniae R6

69.451

100

0.695
  cinA Streptococcus pneumoniae D39

69.212

100

0.692
  cinA Streptococcus suis isolate S10

54.087

99.284

0.537
  cinA Bacillus subtilis subsp. subtilis str. 168

45.735

100

0.461

Multiple sequence alignment