Detailed information NTG1139506

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DQM67_RS04995
• Genome accession: NZ_LS483383
• Coordinates: 980149..980823 (-)
• Length: 224 a.a.
• NCBI ID: WP_005590265.1
• Uniprot ID: A0A428GKV7
• Organism: Streptococcus cristatus ATCC 51100 strain NCTC 12479
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 975149..985823

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM67_RS04975 (NCTC12479_00963)	-	975661..976749 (+)	1089	WP_282645401.1	DEAD/DEAH box helicase	-
DQM67_RS04980 (NCTC12479_00964)	-	976832..978229 (-)	1398	WP_005590268.1	polysaccharide deacetylase family protein	-
DQM67_RS04985 (NCTC12479_00965)	-	978319..978705 (-)	387	WP_005590267.1	VOC family protein	-
DQM67_RS04990 (NCTC12479_00966)	ciaH	978780..980159 (-)	1380	WP_005590266.1	sensor histidine kinase KdpD	Regulator
DQM67_RS04995 (NCTC12479_00967)	ciaR	980149..980823 (-)	675	WP_005590265.1	response regulator transcription factor	Regulator
DQM67_RS05000 (NCTC12479_00968)	-	980944..981384 (-)	441	WP_005590264.1	hypothetical protein	-
DQM67_RS05005 (NCTC12479_00969)	-	981603..984146 (-)	2544	WP_005591931.1	M1 family metallopeptidase	-
DQM67_RS05010 (NCTC12479_00970)	phoU	984371..985024 (-)	654	WP_005591940.1	phosphate signaling complex protein PhoU	-
DQM67_RS05015 (NCTC12479_00971)	pstB	985036..985794 (-)	759	WP_005590258.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25357.04 Da
• Isoelectric Point: 4.2907

>NTDB_id=1139506 DQM67_RS04995 WP_005590265.1 980149..980823(-) (ciaR) [Streptococcus cristatus ATCC 51100 strain NCTC 12479]
MIKILLVEDDLGLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNSTLVDGREVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTAFANNLQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=1139506 DQM67_RS04995 WP_005590265.1 980149..980823(-) (ciaR) [Streptococcus cristatus ATCC 51100 strain NCTC 12479]
ATGATTAAGATTCTATTAGTGGAGGATGACCTCGGTCTGTCAAACTCAGTATTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGATCTTTGACGGCGAAGAAGGCTTATACGAGGCAGAAAGTGGCGTGTATGACCTGATTCTACTGGACTTGATGC
TTCCTGAAAAAGATGGCTTCCAAGTACTCAAAGAATTGCGTGAAAAAGGGGTGAGCACTCCTGTCCTCATCATGACTGCC
AAGGAAAGTATCGATGATAAAGGCCATGGTTTTGAACTCGGAGCTGACGATTACCTAACCAAGCCATTTTATCTGGAAGA
GCTGAAGATGCGGATTCAGGCCTTGCTCAAACGCTCTGGTAAGTTTAATGAAAATACCCTTTCCTATGGCGATGTGACGG
TCAATCTTTCGACCAATTCGACCTTGGTAGATGGAAGAGAAGTTGAGCTACTGGGTAAAGAGTTTGATTTGTTGGTATAC
TTCCTTCAGAATCAGAATGTTATTTTGCCCAAGACTCAAATCTTCGATCGTTTGTGGGGCTTTGACAGCGATACAACGAT
TTCTGTGGTGGAAGTCTATGTATCTAAGATTCGGAAAAAATTGAAAGGAACGGCTTTTGCGAATAATCTTCAAACCCTTC
GCAGTGTCGGTTACATTTTAAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A428GKV7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	89.732	100	0.897
ciaR	Streptococcus pneumoniae D39	89.732	100	0.897
ciaR	Streptococcus pneumoniae R6	89.732	100	0.897
ciaR	Streptococcus pneumoniae TIGR4	89.732	100	0.897
ciaR	Streptococcus mutans UA159	87.892	99.554	0.875
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.897	100	0.375
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.366
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362