Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQM89_RS09065 Genome accession   NZ_LS483382
Coordinates   1764306..1765577 (-) Length   423 a.a.
NCBI ID   WP_076634443.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC13738     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1754584..1781813 1764306..1765577 within 0


Gene organization within MGE regions


Location: 1754584..1781813
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM89_RS09015 (NCTC13738_01786) nrdG 1754584..1755198 (-) 615 WP_021775544.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  DQM89_RS09020 (NCTC13738_01787) - 1755213..1755707 (-) 495 WP_014407930.1 GNAT family N-acetyltransferase -
  DQM89_RS09025 (NCTC13738_01788) - 1755716..1756651 (-) 936 WP_076634441.1 Gfo/Idh/MocA family protein -
  DQM89_RS09605 (NCTC13738_01789) - 1756680..1756826 (-) 147 WP_023610752.1 hypothetical protein -
  DQM89_RS09030 (NCTC13738_01790) nrdD 1757008..1759206 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  DQM89_RS09035 (NCTC13738_01791) - 1759303..1760862 (-) 1560 WP_076634442.1 DUF2079 domain-containing protein -
  DQM89_RS09040 (NCTC13738_01793) - 1761276..1761581 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DQM89_RS09045 (NCTC13738_01794) ruvX 1761593..1762012 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQM89_RS09050 (NCTC13738_01795) - 1762009..1762278 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQM89_RS09055 (NCTC13738_01796) spx 1762392..1762790 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQM89_RS09060 (NCTC13738_01797) recA 1763081..1764217 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  DQM89_RS09065 (NCTC13738_01798) cinA 1764306..1765577 (-) 1272 WP_076634443.1 competence/damage-inducible protein A Machinery gene
  DQM89_RS09070 (NCTC13738_01799) - 1765646..1766206 (-) 561 WP_023610776.1 DNA-3-methyladenine glycosylase I -
  DQM89_RS09075 (NCTC13738_01800) ruvA 1766216..1766812 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  DQM89_RS09080 (NCTC13738_01801) - 1766814..1768034 (-) 1221 WP_076634444.1 MDR family MFS transporter -
  DQM89_RS09085 (NCTC13738_01802) mutL 1768045..1770027 (-) 1983 WP_023610727.1 DNA mismatch repair endonuclease MutL -
  DQM89_RS09090 (NCTC13738_01803) - 1770122..1771267 (-) 1146 WP_021299091.1 tyrosine-type recombinase/integrase -
  DQM89_RS09805 - 1771595..1771738 (+) 144 WP_110410861.1 putative holin-like toxin -
  DQM89_RS09745 (NCTC13738_01805) - 1772541..1773050 (-) 510 WP_003049854.1 helix-turn-helix domain-containing protein -
  DQM89_RS09105 (NCTC13738_01806) - 1773262..1773450 (+) 189 WP_003049853.1 helix-turn-helix domain-containing protein -
  DQM89_RS09110 (NCTC13738_01807) - 1773466..1774074 (+) 609 WP_076634445.1 Bro-N domain-containing protein -
  DQM89_RS09115 (NCTC13738_01808) - 1774095..1774502 (+) 408 WP_021733977.1 hypothetical protein -
  DQM89_RS09120 (NCTC13738_01809) - 1774515..1774847 (+) 333 WP_076634446.1 hypothetical protein -
  DQM89_RS09125 (NCTC13738_01810) - 1775103..1775444 (+) 342 WP_037588219.1 hypothetical protein -
  DQM89_RS09130 (NCTC13738_01811) - 1775431..1775652 (+) 222 WP_003058793.1 hypothetical protein -
  DQM89_RS09135 (NCTC13738_01812) - 1775655..1775846 (+) 192 WP_003058790.1 hypothetical protein -
  DQM89_RS09140 (NCTC13738_01813) - 1775858..1776187 (+) 330 WP_003058810.1 hypothetical protein -
  DQM89_RS09145 (NCTC13738_01814) - 1776190..1776462 (+) 273 WP_001100459.1 hypothetical protein -
  DQM89_RS09150 (NCTC13738_01815) - 1776463..1777320 (+) 858 WP_003058743.1 primase alpha helix C-terminal domain-containing protein -
  DQM89_RS09155 (NCTC13738_01816) - 1777289..1778977 (+) 1689 WP_076634447.1 DNA primase family protein -
  DQM89_RS09160 (NCTC13738_01817) - 1779264..1779437 (+) 174 WP_003045773.1 hypothetical protein -
  DQM89_RS09610 (NCTC13738_01818) - 1779443..1779616 (+) 174 WP_003058787.1 hypothetical protein -
  DQM89_RS09165 (NCTC13738_01819) - 1779618..1780127 (+) 510 WP_003058776.1 hypothetical protein -
  DQM89_RS09170 (NCTC13738_01820) - 1780202..1780690 (+) 489 WP_003058746.1 hypothetical protein -
  DQM89_RS09180 (NCTC13738_01821) - 1781093..1781455 (+) 363 WP_003058730.1 DUF1492 domain-containing protein -
  DQM89_RS09185 (NCTC13738_01822) - 1781430..1781813 (+) 384 WP_003058801.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45978.68 Da        Isoelectric Point: 4.8322

>NTDB_id=1139475 DQM89_RS09065 WP_076634443.1 1764306..1765577(-) (cinA) [Streptococcus pyogenes strain NCTC13738]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSRQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1139475 DQM89_RS09065 WP_076634443.1 1764306..1765577(-) (cinA) [Streptococcus pyogenes strain NCTC13738]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAGACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GCTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.031

100

0.69
  cinA Streptococcus mitis SK321

69.544

98.582

0.686
  cinA Streptococcus mitis NCTC 12261

69.065

98.582

0.681
  cinA Streptococcus pneumoniae TIGR4

68.106

98.582

0.671
  cinA Streptococcus pneumoniae Rx1

68.106

98.582

0.671
  cinA Streptococcus pneumoniae R6

68.106

98.582

0.671
  cinA Streptococcus pneumoniae D39

67.866

98.582

0.669
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment