Detailed information NTG1139117

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DQM54_RS05270
• Genome accession: NZ_LS483375
• Coordinates: 1072338..1073012 (+)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain NCTC3165
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1067338..1078012

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM54_RS05245 (NCTC3165_01044)	-	1067403..1069949 (+)	2547	WP_111723684.1	M1 family metallopeptidase	-
DQM54_RS05250 (NCTC3165_01045)	-	1070129..1070413 (+)	285	WP_045634874.1	helix-turn-helix domain-containing protein	-
DQM54_RS05255 (NCTC3165_01046)	-	1070464..1070790 (+)	327	WP_083277171.1	DMT family transporter	-
DQM54_RS05260 (NCTC3165_01047)	-	1070805..1071608 (+)	804	WP_045634872.1	SDR family NAD(P)-dependent oxidoreductase	-
DQM54_RS05265 (NCTC3165_01048)	-	1071792..1072208 (+)	417	WP_111723685.1	hypothetical protein	-
DQM54_RS05270 (NCTC3165_01049)	ciaR	1072338..1073012 (+)	675	WP_008808730.1	response regulator transcription factor	Regulator
DQM54_RS05275 (NCTC3165_01050)	ciaH	1073002..1074408 (+)	1407	WP_111723686.1	sensor histidine kinase	Regulator
DQM54_RS05280 (NCTC3165_01051)	-	1074556..1076007 (-)	1452	WP_172455829.1	alpha-amylase	-
DQM54_RS05285 (NCTC3165_01052)	-	1076123..1076632 (-)	510	WP_008808727.1	DNA topology modulation protein	-
DQM54_RS05290 (NCTC3165_01053)	rpsT	1076697..1076945 (-)	249	WP_008808726.1	30S ribosomal protein S20	-
DQM54_RS05295 (NCTC3165_01054)	coaA	1077042..1077962 (-)	921	WP_105165144.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=1139117 DQM54_RS05270 WP_008808730.1 1072338..1073012(+) (ciaR) [Streptococcus gordonii strain NCTC3165]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=1139117 DQM54_RS05270 WP_008808730.1 1072338..1073012(+) (ciaR) [Streptococcus gordonii strain NCTC3165]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGACGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGGGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362