Detailed information NTG1139091

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DQM66_RS10915
• Genome accession: NZ_LS483374
• Coordinates: 2041200..2041952 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain NCTC7466
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2036200..2046952

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM66_RS11860	-	2038633..2040236 (-)	1604	Protein_2019	YhgE/Pip family protein	-
DQM66_RS10900 (NCTC7466_02090)	-	2040415..2040957 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
DQM66_RS10915 (NCTC7466_02093)	comE	2041200..2041952 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
DQM66_RS10920 (NCTC7466_02094)	comD/comD1	2041949..2043274 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
DQM66_RS10925 (NCTC7466_02095)	comC/comC1	2043295..2043420 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
DQM66_RS10935 (NCTC7466_02097)	rlmH	2043702..2044181 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM66_RS10940 (NCTC7466_02098)	htrA	2044364..2045545 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
DQM66_RS10945 (NCTC7466_02099)	spo0J	2045603..2046361 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1139091 DQM66_RS10915 WP_000866065.1 2041200..2041952(-) (comE) [Streptococcus pneumoniae strain NCTC7466]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1139091 DQM66_RS10915 WP_000866065.1 2041200..2041952(-) (comE) [Streptococcus pneumoniae strain NCTC7466]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408