Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQM66_RS09265 Genome accession   NZ_LS483374
Coordinates   1734289..1735545 (-) Length   418 a.a.
NCBI ID   WP_000642701.1    Uniprot ID   Q04IM5
Organism   Streptococcus pneumoniae strain NCTC7466     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1726972..1749379 1734289..1735545 within 0


Gene organization within MGE regions


Location: 1726972..1749379
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM66_RS09215 (NCTC7466_01770) - 1726972..1727169 (-) 198 WP_000890144.1 hypothetical protein -
  DQM66_RS09220 (NCTC7466_01771) - 1727173..1727967 (-) 795 WP_001101210.1 hypothetical protein -
  DQM66_RS09225 (NCTC7466_01772) - 1728375..1728800 (-) 426 WP_000204065.1 hypothetical protein -
  DQM66_RS09230 (NCTC7466_01773) - 1728929..1729288 (-) 360 WP_000749822.1 ImmA/IrrE family metallo-endopeptidase -
  DQM66_RS09235 (NCTC7466_01774) - 1729334..1729540 (-) 207 WP_000366091.1 hypothetical protein -
  DQM66_RS09240 - 1729527..1729700 (-) 174 WP_000289349.1 helix-turn-helix domain-containing protein -
  DQM66_RS09245 (NCTC7466_01775) lytA 1730059..1731015 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  DQM66_RS09250 (NCTC7466_01776) - 1731391..1732761 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  DQM66_RS09260 (NCTC7466_01777) recA 1733068..1734234 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  DQM66_RS09265 (NCTC7466_01778) cinA 1734289..1735545 (-) 1257 WP_000642701.1 competence/damage-inducible protein A Machinery gene
  DQM66_RS09270 (NCTC7466_01779) brpA 1735630..1736646 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  DQM66_RS09275 (NCTC7466_01780) - 1736654..1737172 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  DQM66_RS09280 (NCTC7466_01781) tsaE 1737162..1737605 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  DQM66_RS09285 (NCTC7466_01782) comM 1737691..1738311 (-) 621 WP_000839908.1 hypothetical protein Regulator
  DQM66_RS09295 (NCTC7466_01783) - 1738694..1739557 (-) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  DQM66_RS11740 (NCTC7466_01784) - 1739749..1739919 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  DQM66_RS09305 (NCTC7466_01785) pneA1 1740022..1740246 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  DQM66_RS09310 (NCTC7466_01786) pneA2 1740253..1740441 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  DQM66_RS09315 (NCTC7466_01787) - 1740557..1743547 (+) 2991 WP_000875575.1 type 2 lanthipeptide synthetase LanM family protein -
  DQM66_RS09320 (NCTC7466_01788) - 1743897..1744601 (+) 705 WP_001033170.1 flavodoxin family protein -
  DQM66_RS09325 (NCTC7466_01789) - 1744582..1745511 (+) 930 WP_000912955.1 M50 family metallopeptidase -
  DQM66_RS09330 (NCTC7466_01790) - 1745508..1747616 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  DQM66_RS09335 (NCTC7466_01791) - 1747640..1749379 (+) 1740 WP_000699969.1 S8 family peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45064.41 Da        Isoelectric Point: 4.5211

>NTDB_id=1139068 DQM66_RS09265 WP_000642701.1 1734289..1735545(-) (cinA) [Streptococcus pneumoniae strain NCTC7466]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGATEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQVQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=1139068 DQM66_RS09265 WP_000642701.1 1734289..1735545(-) (cinA) [Streptococcus pneumoniae strain NCTC7466]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGGCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGTTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q04IM5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae D39

100

100

1
  cinA Streptococcus pneumoniae Rx1

99.761

100

0.998
  cinA Streptococcus pneumoniae R6

99.761

100

0.998
  cinA Streptococcus pneumoniae TIGR4

99.043

100

0.99
  cinA Streptococcus mitis SK321

93.062

100

0.931
  cinA Streptococcus mitis NCTC 12261

92.823

100

0.928
  cinA Streptococcus mutans UA159

70.335

100

0.703
  cinA Streptococcus suis isolate S10

54.567

99.522

0.543
  cinA Bacillus subtilis subsp. subtilis str. 168

44.976

100

0.45

Multiple sequence alignment