Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQM52_RS10175 Genome accession   NZ_LS483367
Coordinates   2020501..2021772 (-) Length   423 a.a.
NCBI ID   WP_011285266.1    Uniprot ID   Q48QW6
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 2015501..2026772
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM52_RS10145 (NCTC5371_02065) - 2015917..2016222 (-) 306 WP_003058733.1 DUF1292 domain-containing protein -
  DQM52_RS10150 (NCTC5371_02066) ruvX 2016233..2016652 (-) 420 WP_003053103.1 Holliday junction resolvase RuvX -
  DQM52_RS10155 (NCTC5371_02067) - 2016649..2016918 (-) 270 WP_003045720.1 IreB family regulatory phosphoprotein -
  DQM52_RS10160 (NCTC5371_02068) spx 2017030..2017428 (-) 399 WP_003053105.1 transcriptional regulator Spx -
  DQM52_RS10165 (NCTC5371_02069) - 2017677..2019160 (-) 1484 Protein_1928 IS1182 family transposase -
  DQM52_RS10170 (NCTC5371_02070) recA 2019276..2020412 (-) 1137 WP_111681930.1 recombinase RecA Machinery gene
  DQM52_RS10175 (NCTC5371_02071) cinA 2020501..2021772 (-) 1272 WP_011285266.1 competence/damage-inducible protein A Machinery gene
  DQM52_RS10180 (NCTC5371_02072) - 2021896..2022249 (-) 354 WP_003058738.1 VOC family protein -
  DQM52_RS10185 (NCTC5371_02073) - 2022252..2022824 (-) 573 WP_003058799.1 DNA-3-methyladenine glycosylase I -
  DQM52_RS10190 (NCTC5371_02074) ruvA 2022834..2023427 (-) 594 WP_003058778.1 Holliday junction branch migration protein RuvA -
  DQM52_RS10195 (NCTC5371_02075) - 2023429..2024649 (-) 1221 WP_003058727.1 MFS transporter -
  DQM52_RS10200 (NCTC5371_02076) mutL 2024660..2026642 (-) 1983 WP_046159730.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45990.74 Da        Isoelectric Point: 4.8322

>NTDB_id=1138869 DQM52_RS10175 WP_011285266.1 2020501..2021772(-) (cinA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1138869 DQM52_RS10175 WP_011285266.1 2020501..2021772(-) (cinA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTCATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q48QW6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment