Detailed information NTG1137732

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DQM73_RS12240
• Genome accession: NZ_LS483346
• Coordinates: 2444097..2444861 (-)
• Length: 254 a.a.
• NCBI ID: WP_002899424.1
• Uniprot ID: A0A0B7GUD9
• Organism: Streptococcus sanguinis strain NCTC11085
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	2442459..2443810	2444097..2444861	flank	287

Gene organization within MGE regions

Location: 2442459..2444861

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM73_RS12225	-	2442459..2443810 (+)	1352	WP_111681466.1	IS3 family transposase	-
DQM73_RS12240 (NCTC11085_02410)	comE	2444097..2444861 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator

Sequence

Protein

• Length: 254 a.a.
• Molecular weight: 29851.13 Da
• Isoelectric Point: 8.0162

>NTDB_id=1137732 DQM73_RS12240 WP_002899424.1 2444097..2444861(-) (comE) [Streptococcus sanguinis strain NCTC11085]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENKGKRVDKA

Nucleotide

• Length: 765 bp

>NTDB_id=1137732 DQM73_RS12240 WP_002899424.1 2444097..2444861(-) (comE) [Streptococcus sanguinis strain NCTC11085]
ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGACATTAAGGGGGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATCCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATCGATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTTAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCACATAAATCTTATCTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTATGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATTTG
AAAGATATTTTCGAAAATAAAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (4-121)

3D structure

• AlphaFold DB: A0A0B7GUD9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus infantis strain Atu-4	68.4	98.425	0.673
comE/comE2	Streptococcus gordonii strain NCTC7865	68.4	98.425	0.673
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	68.4	98.425	0.673
comE	Streptococcus mitis NCTC 12261	68	98.425	0.669
comE	Streptococcus mitis SK321	67.2	98.425	0.661
comE	Streptococcus pneumoniae Rx1	66.8	98.425	0.657
comE	Streptococcus pneumoniae D39	66.8	98.425	0.657
comE	Streptococcus pneumoniae R6	66.8	98.425	0.657
comE	Streptococcus pneumoniae TIGR4	66.8	98.425	0.657
comE/blpR	Streptococcus mutans UA159	38.8	98.425	0.382