Detailed information NTG1137497

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: DQL23_RS07590
• Genome accession: NZ_LS483341
• Coordinates: 1563112..1563786 (-)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain NCTC7865
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1558112..1568786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL23_RS07570 (NCTC7865_01526)	rpsT	1558840..1559088 (+)	249	WP_008808726.1	30S ribosomal protein S20	-
DQL23_RS07575 (NCTC7865_01527)	-	1559319..1560770 (+)	1452	WP_060553638.1	alpha-amylase	-
DQL23_RS07580 (NCTC7865_01528)	-	1560794..1561720 (-)	927	WP_060553639.1	ketopantoate reductase family protein	-
DQL23_RS07585 (NCTC7865_01529)	ciaH	1561722..1563122 (-)	1401	WP_060553640.1	sensor histidine kinase	Regulator
DQL23_RS07590 (NCTC7865_01530)	ciaR	1563112..1563786 (-)	675	WP_008808730.1	response regulator transcription factor	Regulator
DQL23_RS07595 (NCTC7865_01531)	-	1563917..1564354 (-)	438	WP_060553641.1	hypothetical protein	-
DQL23_RS07600 (NCTC7865_01532)	-	1564574..1565116 (+)	543	WP_060553642.1	biotin transporter BioY	-
DQL23_RS07605 (NCTC7865_01533)	-	1565173..1567716 (-)	2544	WP_060553643.1	M1 family metallopeptidase	-
DQL23_RS07610 (NCTC7865_01534)	-	1567847..1568173 (-)	327	WP_060553644.1	hypothetical protein	-
DQL23_RS07615 (NCTC7865_01535)	-	1568182..1568478 (-)	297	WP_060553645.1	hypothetical protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=1137497 DQL23_RS07590 WP_008808730.1 1563112..1563786(-) (ciaR) [Streptococcus gordonii strain NCTC7865]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=1137497 DQL23_RS07590 WP_008808730.1 1563112..1563786(-) (ciaR) [Streptococcus gordonii strain NCTC7865]
ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCTGTATTTGATTTCTTAGATGACTTTGCAGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC
TCCCTGAGAAAGATGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGGCATGGTTTTGAATTGGGTGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATTCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGACTCTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362