Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQL30_RS08775 Genome accession   NZ_LS483333
Coordinates   1727549..1728820 (-) Length   423 a.a.
NCBI ID   WP_111714003.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12048     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1722549..1733820
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL30_RS08750 (NCTC12048_01736) - 1724520..1724825 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DQL30_RS08755 (NCTC12048_01737) ruvX 1724837..1725256 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQL30_RS08760 (NCTC12048_01738) - 1725253..1725522 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQL30_RS08765 (NCTC12048_01739) spx 1725635..1726033 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQL30_RS08770 (NCTC12048_01740) recA 1726324..1727460 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  DQL30_RS08775 (NCTC12048_01741) cinA 1727549..1728820 (-) 1272 WP_111714003.1 competence/damage-inducible protein A Machinery gene
  DQL30_RS08780 (NCTC12048_01742) - 1728889..1729449 (-) 561 WP_023079151.1 DNA-3-methyladenine glycosylase I -
  DQL30_RS08785 (NCTC12048_01743) ruvA 1729459..1730055 (-) 597 WP_011185063.1 Holliday junction branch migration protein RuvA -
  DQL30_RS08790 (NCTC12048_01744) - 1730057..1731277 (-) 1221 WP_111714004.1 MDR family MFS transporter -
  DQL30_RS08795 (NCTC12048_01745) mutL 1731288..1733270 (-) 1983 WP_111714005.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46002.79 Da        Isoelectric Point: 4.8322

>NTDB_id=1137049 DQL30_RS08775 WP_111714003.1 1727549..1728820(-) (cinA) [Streptococcus pyogenes strain NCTC12048]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFVTVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKLHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1137049 DQL30_RS08775 WP_111714003.1 1727549..1728820(-) (cinA) [Streptococcus pyogenes strain NCTC12048]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGATTCGTCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATTGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.976

100

0.7
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment