Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQL25_RS09065 Genome accession   NZ_LS483330
Coordinates   1778727..1779998 (-) Length   423 a.a.
NCBI ID   WP_032459984.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8328     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1773727..1784998
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL25_RS09040 (NCTC8328_01797) - 1775696..1776001 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DQL25_RS09045 (NCTC8328_01798) ruvX 1776013..1776432 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQL25_RS09050 (NCTC8328_01799) - 1776429..1776698 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQL25_RS09055 (NCTC8328_01800) spx 1776813..1777211 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQL25_RS09060 (NCTC8328_01801) recA 1777502..1778638 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  DQL25_RS09065 (NCTC8328_01802) cinA 1778727..1779998 (-) 1272 WP_032459984.1 competence/damage-inducible protein A Machinery gene
  DQL25_RS09070 (NCTC8328_01803) - 1780067..1780627 (-) 561 WP_111703697.1 DNA-3-methyladenine glycosylase I -
  DQL25_RS09075 (NCTC8328_01804) ruvA 1780637..1781233 (-) 597 WP_038434336.1 Holliday junction branch migration protein RuvA -
  DQL25_RS09080 (NCTC8328_01805) - 1781235..1782455 (-) 1221 WP_111703699.1 MDR family MFS transporter -
  DQL25_RS09085 (NCTC8328_01806) mutL 1782466..1784448 (-) 1983 WP_111703701.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46018.75 Da        Isoelectric Point: 4.8322

>NTDB_id=1136879 DQL25_RS09065 WP_032459984.1 1778727..1779998(-) (cinA) [Streptococcus pyogenes strain NCTC8328]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1136879 DQL25_RS09065 WP_032459984.1 1778727..1779998(-) (cinA) [Streptococcus pyogenes strain NCTC8328]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.976

100

0.7
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.89

98.818

0.463

Multiple sequence alignment