Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQM44_RS10020 Genome accession   NZ_LS483318
Coordinates   2001359..2002630 (-) Length   423 a.a.
NCBI ID   WP_003058772.1    Uniprot ID   A0A9X8T4Y6
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2003219..2069267 2001359..2002630 flank 589


Gene organization within MGE regions


Location: 2001359..2069267
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM44_RS10020 (NCTC5370_02054) cinA 2001359..2002630 (-) 1272 WP_003058772.1 competence/damage-inducible protein A Machinery gene
  DQM44_RS10025 (NCTC5370_02055) - 2002754..2003107 (-) 354 WP_003058738.1 VOC family protein -
  DQM44_RS10030 (NCTC5370_02056) - 2003110..2003682 (-) 573 WP_003058799.1 DNA-3-methyladenine glycosylase I -
  DQM44_RS10035 (NCTC5370_02057) ruvA 2003692..2004285 (-) 594 WP_022555247.1 Holliday junction branch migration protein RuvA -
  DQM44_RS10040 (NCTC5370_02058) - 2004287..2005507 (-) 1221 WP_022555248.1 MFS transporter -
  DQM44_RS10045 (NCTC5370_02059) mutL 2005518..2007500 (-) 1983 WP_044565652.1 DNA mismatch repair endonuclease MutL -
  DQM44_RS10050 (NCTC5370_02060) mutS 2007628..2010183 (-) 2556 WP_111711703.1 DNA mismatch repair protein MutS -
  DQM44_RS10055 (NCTC5370_02061) - 2010170..2010523 (-) 354 WP_015058137.1 YlbF family regulator -
  DQM44_RS10060 (NCTC5370_02062) argR 2010520..2010957 (-) 438 WP_003055516.1 arginine repressor -
  DQM44_RS10065 (NCTC5370_02063) argS 2011246..2012937 (+) 1692 WP_012767645.1 arginine--tRNA ligase -
  DQM44_RS10710 (NCTC5370_02064) - 2013007..2013762 (-) 756 WP_231871609.1 ATP-binding cassette domain-containing protein -
  DQM44_RS10715 (NCTC5370_02065) - 2013743..2014405 (-) 663 WP_231871610.1 ATP-binding cassette domain-containing protein -
  DQM44_RS10075 (NCTC5370_02066) - 2014582..2015496 (-) 915 WP_022555275.1 YitT family protein -
  DQM44_RS10080 (NCTC5370_02067) - 2015526..2016425 (-) 900 WP_003060132.1 YitT family protein -
  DQM44_RS10085 (NCTC5370_02068) - 2016446..2017387 (-) 942 WP_003055524.1 YitT family protein -
  DQM44_RS10090 (NCTC5370_02069) aspS 2017380..2019128 (-) 1749 WP_111711704.1 aspartate--tRNA ligase -
  DQM44_RS10095 (NCTC5370_02070) hisS 2019466..2020746 (-) 1281 WP_111711723.1 histidine--tRNA ligase -
  DQM44_RS10100 (NCTC5370_02071) rpmF 2021136..2021318 (+) 183 WP_000290414.1 50S ribosomal protein L32 -
  DQM44_RS10105 (NCTC5370_02072) rpmG 2021334..2021483 (+) 150 WP_002982147.1 50S ribosomal protein L33 -
  DQM44_RS10110 (NCTC5370_02073) - 2021671..2022513 (+) 843 WP_003059586.1 DUF368 domain-containing protein -
  DQM44_RS10115 (NCTC5370_02074) - 2022596..2022916 (-) 321 WP_003059588.1 thioredoxin family protein -
  DQM44_RS10120 (NCTC5370_02075) - 2022998..2023612 (-) 615 WP_044565657.1 CoA pyrophosphatase -
  DQM44_RS10125 (NCTC5370_02076) - 2023815..2024141 (+) 327 WP_022555279.1 PadR family transcriptional regulator -
  DQM44_RS10130 (NCTC5370_02077) - 2024128..2024715 (+) 588 WP_003060115.1 DUF1700 domain-containing protein -
  DQM44_RS10135 (NCTC5370_02078) - 2024712..2025785 (+) 1074 WP_022555280.1 DUF4097 family beta strand repeat-containing protein -
  DQM44_RS10140 (NCTC5370_02079) - 2025910..2028183 (-) 2274 WP_111711705.1 YhgE/Pip domain-containing protein -
  DQM44_RS10145 (NCTC5370_02080) - 2028318..2028851 (+) 534 WP_003059589.1 TetR/AcrR family transcriptional regulator -
  DQM44_RS10150 - 2028879..2030349 (-) 1471 Protein_1927 IS1182 family transposase -
  DQM44_RS10155 (NCTC5370_02082) - 2031433..2031864 (-) 432 WP_003057167.1 DUF1492 domain-containing protein -
  DQM44_RS10720 (NCTC5370_02083) - 2032363..2032866 (-) 504 WP_111711706.1 hypothetical protein -
  DQM44_RS10165 (NCTC5370_02084) - 2032960..2033490 (-) 531 WP_003057164.1 hypothetical protein -
  DQM44_RS10520 (NCTC5370_02085) - 2033511..2033684 (-) 174 WP_000694575.1 hypothetical protein -
  DQM44_RS10170 (NCTC5370_02086) - 2034020..2035522 (-) 1503 WP_003058303.1 DNA primase family protein -
  DQM44_RS10175 (NCTC5370_02087) - 2035542..2036411 (-) 870 WP_003058307.1 primase alpha helix C-terminal domain-containing protein -
  DQM44_RS10180 (NCTC5370_02088) - 2036546..2036827 (-) 282 WP_047207332.1 hypothetical protein -
  DQM44_RS10185 (NCTC5370_02089) - 2036830..2037159 (-) 330 WP_003045763.1 hypothetical protein -
  DQM44_RS10190 (NCTC5370_02090) - 2037171..2037362 (-) 192 WP_011889227.1 hypothetical protein -
  DQM44_RS10195 (NCTC5370_02091) - 2037362..2037694 (-) 333 WP_111711707.1 hypothetical protein -
  DQM44_RS10200 (NCTC5370_02092) - 2037965..2038153 (-) 189 WP_016481383.1 helix-turn-helix transcriptional regulator -
  DQM44_RS10205 (NCTC5370_02093) - 2038343..2038963 (+) 621 WP_111688375.1 helix-turn-helix transcriptional regulator -
  DQM44_RS10215 (NCTC5370_02094) - 2039338..2040342 (+) 1005 WP_003055091.1 hypothetical protein -
  DQM44_RS10220 (NCTC5370_02095) - 2040342..2040794 (+) 453 WP_003055128.1 Fic family protein -
  DQM44_RS10225 (NCTC5370_02096) - 2040889..2042055 (+) 1167 WP_111711724.1 site-specific integrase -
  DQM44_RS10230 (NCTC5370_02097) rpsD 2042150..2042761 (-) 612 WP_003053152.1 30S ribosomal protein S4 -
  DQM44_RS10240 (NCTC5370_02098) - 2043052..2044185 (-) 1134 WP_111711708.1 ISAs1-like element IS1548 family transposase -
  DQM44_RS10245 (NCTC5370_02099) - 2044231..2044743 (-) 513 WP_015058167.1 helix-turn-helix transcriptional regulator -
  DQM44_RS10250 (NCTC5370_02100) - 2044896..2045168 (-) 273 WP_003055136.1 Veg family protein -
  DQM44_RS10255 (NCTC5370_02101) dnaB 2045184..2046545 (-) 1362 WP_003055105.1 replicative DNA helicase -
  DQM44_RS10260 (NCTC5370_02102) rplI 2046581..2047033 (-) 453 WP_014612656.1 50S ribosomal protein L9 -
  DQM44_RS10265 (NCTC5370_02103) - 2047030..2049006 (-) 1977 WP_014612657.1 DHH family phosphoesterase -
  DQM44_RS10270 (NCTC5370_02104) - 2049162..2050295 (-) 1134 WP_042358027.1 ISAs1-like element IS1548 family transposase -
  DQM44_RS10275 (NCTC5370_02105) mnmG 2050422..2052320 (-) 1899 WP_003055145.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
  DQM44_RS10280 (NCTC5370_02106) - 2052372..2052821 (-) 450 WP_022555286.1 NUDIX domain-containing protein -
  DQM44_RS10285 (NCTC5370_02107) - 2053035..2053643 (-) 609 WP_046166181.1 MarC family protein -
  DQM44_RS10290 (NCTC5370_02108) mnmA 2053675..2054796 (-) 1122 WP_003055143.1 tRNA 2-thiouridine(34) synthase MnmA -
  DQM44_RS10295 (NCTC5370_02109) sdaAB 2055093..2055764 (+) 672 WP_003055144.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -
  DQM44_RS10300 (NCTC5370_02110) sdaAA 2055776..2056648 (+) 873 WP_003055113.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  DQM44_RS10305 (NCTC5370_02111) - 2056674..2057321 (+) 648 WP_003055101.1 HAD hydrolase-like protein -
  DQM44_RS10310 (NCTC5370_02112) - 2057384..2057998 (-) 615 WP_022555289.1 transglycosylase SLT domain-containing protein -
  DQM44_RS10315 (NCTC5370_02113) - 2058184..2058984 (-) 801 WP_022555290.1 energy-coupling factor transporter transmembrane protein EcfT -
  DQM44_RS10320 (NCTC5370_02114) - 2058977..2059819 (-) 843 WP_003055138.1 energy-coupling factor ABC transporter ATP-binding protein -
  DQM44_RS10325 (NCTC5370_02115) - 2059795..2060634 (-) 840 WP_003055130.1 energy-coupling factor ABC transporter ATP-binding protein -
  DQM44_RS10330 (NCTC5370_02116) pgsA 2060637..2061179 (-) 543 WP_003062173.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  DQM44_RS10335 (NCTC5370_02117) - 2061193..2062224 (-) 1032 WP_003061371.1 helix-turn-helix domain-containing protein -
  DQM44_RS10340 (NCTC5370_02118) - 2062274..2063557 (-) 1284 WP_003055116.1 pitrilysin family protein -
  DQM44_RS10345 (NCTC5370_02119) - 2063559..2064803 (-) 1245 WP_022555293.1 pitrilysin family protein -
  DQM44_RS10350 (NCTC5370_02120) yaaA 2065112..2065525 (+) 414 WP_003055132.1 S4 domain-containing protein YaaA -
  DQM44_RS10355 (NCTC5370_02121) recF 2065527..2066633 (+) 1107 WP_003055088.1 DNA replication/repair protein RecF -
  DQM44_RS10360 (NCTC5370_02122) - 2066690..2067553 (-) 864 WP_003055126.1 GRP family sugar transporter -
  DQM44_RS10365 (NCTC5370_02123) guaB 2067765..2069246 (-) 1482 WP_003060436.1 IMP dehydrogenase -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46007.41 Da        Isoelectric Point: 4.7637

>NTDB_id=1136232 DQM44_RS10020 WP_003058772.1 2001359..2002630(-) (cinA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
MKAELITVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVIATASQRSDLVILCGGLGPTEDDLTKQT
LAKYLNRDLVFEEQASQKLDAFYASRKESSRTANNAKQAQIIAGSSPLQNRTGLAVGGLITVNEVTYVVLPGPPSELKPM
VNEELLPFLSTQSRKLYSRVLRFFGIGESQLVTVLSDLIENQTDPTIAPYAKTGEVTLRLSTKAENQTLADTKLDPLEAQ
LLSRKTPDNQSLSDFLYGYREDNSLAREVFELLVKYDKTITAAESLTAGLFQSTLASFSGASQVFNGGFVTYSMEEKARM
LGIPLEDLISHGVVSAYTAEKMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRSDV
RHIATLHAFNMVRKTLLKPENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1136232 DQM44_RS10020 WP_003058772.1 2001359..2002630(-) (cinA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC5370]
ATGAAAGCTGAACTGATTACAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGATAACGAGGAGCGTTTACTTTCAGTGATTG
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGTCTTGGCCCCACGGAAGATGATTTAACCAAGCAGACT
TTAGCAAAATATCTTAATAGAGATTTGGTCTTTGAAGAACAAGCTAGTCAAAAATTGGACGCTTTTTATGCTAGTCGTAA
AGAGTCGTCTCGAACGGCAAATAATGCTAAGCAGGCTCAAATCATTGCTGGTTCAAGCCCTCTGCAAAATAGAACAGGAC
TTGCAGTGGGTGGCTTAATCACTGTTAATGAGGTGACTTATGTTGTTTTACCCGGGCCGCCAAGTGAATTAAAACCTATG
GTTAATGAGGAACTGCTTCCTTTTTTGTCCACACAATCTCGCAAACTTTATTCGAGAGTTTTACGATTTTTTGGGATTGG
TGAGAGTCAGCTGGTGACGGTCTTATCAGACCTTATTGAGAATCAAACTGATCCTACTATTGCACCTTATGCCAAAACTG
GTGAAGTGACCCTTCGTTTATCAACGAAAGCTGAAAATCAAACATTAGCAGATACGAAATTAGATCCACTAGAAGCGCAG
CTATTGTCGCGAAAAACTCCTGACAACCAGTCGTTATCAGATTTTCTTTATGGCTATAGGGAGGATAATTCCTTAGCGCG
TGAGGTATTTGAGCTCTTAGTAAAATATGATAAGACAATTACTGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTTCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAGAATG
CTAGGCATTCCTTTAGAGGATTTGATATCGCATGGAGTTGTTAGTGCTTATACGGCCGAGAAGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGCCGTTCAGATGTG
CGTCATATTGCGACTTTACATGCTTTTAATATGGTCCGTAAAACTTTATTAAAACCTGAAAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

72.577

100

0.726
  cinA Streptococcus mitis SK321

70.983

98.582

0.7
  cinA Streptococcus mitis NCTC 12261

70.024

98.582

0.69
  cinA Streptococcus pneumoniae TIGR4

69.784

98.582

0.688
  cinA Streptococcus pneumoniae Rx1

69.784

98.582

0.688
  cinA Streptococcus pneumoniae R6

69.784

98.582

0.688
  cinA Streptococcus pneumoniae D39

69.544

98.582

0.686
  cinA Streptococcus suis isolate S10

52.644

98.345

0.518
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

98.818

0.449

Multiple sequence alignment