Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQL09_RS09620 Genome accession   NZ_LS483307
Coordinates   1836543..1837814 (-) Length   423 a.a.
NCBI ID   WP_111677539.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC5163     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1831543..1842814
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL09_RS09595 (NCTC5163_01916) - 1833513..1833818 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DQL09_RS09600 (NCTC5163_01917) ruvX 1833830..1834249 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQL09_RS09605 (NCTC5163_01918) - 1834246..1834515 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQL09_RS09610 (NCTC5163_01919) spx 1834629..1835027 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQL09_RS09615 (NCTC5163_01920) recA 1835318..1836454 (-) 1137 WP_111677538.1 recombinase RecA Machinery gene
  DQL09_RS09620 (NCTC5163_01921) cinA 1836543..1837814 (-) 1272 WP_111677539.1 competence/damage-inducible protein A Machinery gene
  DQL09_RS09625 (NCTC5163_01922) - 1837883..1838443 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  DQL09_RS09630 (NCTC5163_01923) ruvA 1838453..1839049 (-) 597 WP_111677540.1 Holliday junction branch migration protein RuvA -
  DQL09_RS09635 (NCTC5163_01924) - 1839051..1840271 (-) 1221 WP_002982178.1 MDR family MFS transporter -
  DQL09_RS09640 (NCTC5163_01925) mutL 1840282..1842264 (-) 1983 WP_111677601.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45976.71 Da        Isoelectric Point: 4.8322

>NTDB_id=1135801 DQL09_RS09620 WP_111677539.1 1836543..1837814(-) (cinA) [Streptococcus pyogenes strain NCTC5163]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQSLADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1135801 DQL09_RS09620 WP_111677539.1 1836543..1837814(-) (cinA) [Streptococcus pyogenes strain NCTC5163]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTTTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAATCAATCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAACTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGCGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment