Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   DQM39_RS09445 Genome accession   NZ_LS483298
Coordinates   1822113..1823384 (-) Length   423 a.a.
NCBI ID   WP_002982184.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8225     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1817113..1828384
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM39_RS09420 (NCTC8225_01883) - 1819084..1819389 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  DQM39_RS09425 (NCTC8225_01884) ruvX 1819401..1819820 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  DQM39_RS09430 (NCTC8225_01885) - 1819817..1820086 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  DQM39_RS09435 (NCTC8225_01886) spx 1820199..1820597 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  DQM39_RS09440 (NCTC8225_01887) recA 1820888..1822024 (-) 1137 WP_002982186.1 recombinase RecA Machinery gene
  DQM39_RS09445 (NCTC8225_01888) cinA 1822113..1823384 (-) 1272 WP_002982184.1 competence/damage-inducible protein A Machinery gene
  DQM39_RS09450 (NCTC8225_01889) - 1823453..1824013 (-) 561 WP_023611248.1 DNA-3-methyladenine glycosylase I -
  DQM39_RS09455 (NCTC8225_01890) ruvA 1824023..1824619 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA -
  DQM39_RS09460 (NCTC8225_01891) - 1824621..1825841 (-) 1221 WP_002982178.1 MDR family MFS transporter -
  DQM39_RS09465 (NCTC8225_01892) mutL 1825852..1827834 (-) 1983 WP_011018317.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46018.79 Da        Isoelectric Point: 4.8359

>NTDB_id=1135493 DQM39_RS09445 WP_002982184.1 1822113..1823384(-) (cinA) [Streptococcus pyogenes strain NCTC8225]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYEKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKIESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1135493 DQM39_RS09445 WP_002982184.1 1822113..1823384(-) (cinA) [Streptococcus pyogenes strain NCTC8225]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGAAAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GCTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGATAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment