Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   H0508_RS00365 Genome accession   NZ_LR822014
Coordinates   64406..65677 (+) Length   423 a.a.
NCBI ID   WP_011225285.1    Uniprot ID   Q5M6H3
Organism   Streptococcus thermophilus isolate STH_CIRM_36     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 59406..70677
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0508_RS00335 (STHERMO_0063) - 59741..60132 (-) 392 Protein_45 LytTR family DNA-binding domain-containing protein -
  H0508_RS00340 (STHERMO_0064) - 60356..60661 (+) 306 WP_011225281.1 hypothetical protein -
  H0508_RS00345 (STHERMO_0065) mutL 60713..62656 (+) 1944 WP_011225282.1 DNA mismatch repair endonuclease MutL -
  H0508_RS00350 (STHERMO_0066) - 62786..63007 (+) 222 WP_041826940.1 hypothetical protein -
  H0508_RS00355 (STHERMO_0067) ruvA 63159..63749 (+) 591 WP_002949053.1 Holliday junction branch migration protein RuvA -
  H0508_RS00360 (STHERMO_0068) - 63756..64310 (+) 555 WP_011225284.1 DNA-3-methyladenine glycosylase I -
  H0508_RS00365 (STHERMO_0069) cinA 64406..65677 (+) 1272 WP_011225285.1 competence/damage-inducible protein A Machinery gene
  H0508_RS00370 (STHERMO_0070) recA 65713..66867 (+) 1155 WP_002949056.1 recombinase RecA Machinery gene
  H0508_RS00375 (STHERMO_0071) spx 67044..67442 (+) 399 WP_002949058.1 transcriptional regulator Spx -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45984.33 Da        Isoelectric Point: 5.0042

>NTDB_id=1130823 H0508_RS00365 WP_011225285.1 64406..65677(+) (cinA) [Streptococcus thermophilus isolate STH_CIRM_36]
MKAELIAVGTEILTGQITNTNAQFLSEKLAELGIDVYFHTAVGDNENRLLSVLDQSSKRSDLVILCGGLGPTEDDLTKQT
LAKFLGKELIFDEEASKKLDSFFATRPKHTRTPNNERQAQIVEGAVPLQNLTGLAVGGIITVEGVTYVVLPGPPSELKPM
VNQELIPALTENHTTLYSRVLRFFGVGESQLVTIIKDLIVNQTDPTIAPYAKVGEVTLRLSTKASSQEEADRKLDVLEEQ
IRSTKTLDGKSLSDLIYGYGESNSLAYEVFYLLKKYGKTITAAESLTAGLFQASVADFPGASQVFKGGFVTYSMEEKAKM
LDIPLSKLEEHGVVSHFTAEKMAEGARVKTDSDYGIALTGVAGPDALEGHQAGTVFIGIADRNQVRSIKVVIGGRSRSDV
RYISTLYAFNLVRQALLQEDNSI

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1130823 H0508_RS00365 WP_011225285.1 64406..65677(+) (cinA) [Streptococcus thermophilus isolate STH_CIRM_36]
ATGAAAGCTGAATTGATTGCAGTAGGAACTGAAATTCTTACAGGGCAAATCACCAATACCAATGCCCAATTTTTATCTGA
AAAACTAGCTGAATTAGGAATTGACGTGTATTTTCACACAGCGGTAGGAGACAATGAAAACCGTCTACTTTCAGTCTTAG
ACCAGTCTAGTAAACGTAGCGATTTAGTCATACTCTGTGGAGGACTTGGCCCTACTGAGGATGACCTAACCAAACAAACA
TTGGCTAAGTTTTTAGGCAAAGAACTCATTTTTGATGAGGAGGCAAGTAAAAAACTGGATAGTTTCTTTGCTACTCGTCC
TAAACATACACGAACGCCTAATAATGAACGCCAAGCGCAAATTGTTGAGGGGGCTGTCCCCTTGCAAAATCTCACAGGTC
TGGCAGTTGGAGGAATTATTACTGTTGAAGGAGTGACCTATGTTGTCTTGCCTGGTCCGCCAAGTGAACTCAAACCTATG
GTGAACCAAGAGCTTATTCCAGCTCTTACAGAGAATCATACTACGCTTTATTCTAGAGTCCTAAGGTTTTTTGGTGTTGG
AGAAAGTCAATTGGTGACTATTATTAAAGATCTCATTGTTAACCAAACAGACCCAACCATTGCGCCCTATGCTAAAGTGG
GAGAAGTGACCCTTCGCTTATCAACAAAGGCATCGTCGCAAGAAGAAGCGGATCGAAAACTAGATGTTTTAGAAGAACAA
ATTCGTTCTACTAAAACTCTAGATGGAAAAAGCTTGTCTGATCTCATCTATGGATATGGAGAATCAAATAGCTTAGCTTA
TGAAGTGTTCTATTTGCTTAAGAAATATGGCAAAACTATTACTGCAGCTGAAAGTTTAACAGCTGGCTTATTTCAAGCTA
GTGTTGCTGATTTTCCTGGAGCTTCACAAGTATTCAAGGGTGGTTTTGTCACCTATAGCATGGAAGAAAAAGCTAAAATG
TTGGATATTCCCTTATCTAAATTAGAAGAGCATGGTGTTGTTAGTCATTTTACAGCAGAAAAAATGGCTGAGGGTGCCCG
AGTTAAGACAGATAGTGATTACGGAATTGCGCTTACTGGAGTAGCAGGACCAGATGCTTTGGAAGGGCATCAAGCAGGTA
CAGTCTTTATTGGTATTGCCGATAGAAACCAAGTGCGGTCAATTAAGGTTGTTATAGGTGGAAGAAGTCGATCTGATGTT
AGATATATCAGTACACTCTATGCCTTTAACCTAGTTCGCCAAGCTTTATTACAAGAGGACAACTCAATTTAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(264-415)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M6H3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

74.94

99.054

0.742
  cinA Streptococcus mitis NCTC 12261

73.747

99.054

0.73
  cinA Streptococcus pneumoniae TIGR4

72.554

99.054

0.719
  cinA Streptococcus pneumoniae Rx1

72.315

99.054

0.716
  cinA Streptococcus pneumoniae R6

72.315

99.054

0.716
  cinA Streptococcus pneumoniae D39

72.076

99.054

0.714
  cinA Streptococcus mutans UA159

70.071

99.527

0.697
  cinA Streptococcus suis isolate S10

54.327

98.345

0.534
  cinA Bacillus subtilis subsp. subtilis str. 168

44.418

99.527

0.442

Multiple sequence alignment