Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   H0503_RS00365 Genome accession   NZ_LR822009
Coordinates   64183..65454 (+) Length   423 a.a.
NCBI ID   WP_011680605.1    Uniprot ID   Q03MX6
Organism   Streptococcus thermophilus isolate STH_CIRM_19     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 59183..70454
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0503_RS00335 (STHERMO_0063) - 59518..59909 (-) 392 Protein_46 LytTR family DNA-binding domain-containing protein -
  H0503_RS00340 (STHERMO_0064) - 60133..60438 (+) 306 WP_002949050.1 hypothetical protein -
  H0503_RS00345 (STHERMO_0065) mutL 60490..62433 (+) 1944 WP_014607839.1 DNA mismatch repair endonuclease MutL -
  H0503_RS00350 (STHERMO_0066) - 62563..62784 (+) 222 WP_002949052.1 hypothetical protein -
  H0503_RS00355 (STHERMO_0067) ruvA 62936..63526 (+) 591 WP_011680603.1 Holliday junction branch migration protein RuvA -
  H0503_RS00360 (STHERMO_0068) - 63533..64087 (+) 555 WP_011680604.1 DNA-3-methyladenine glycosylase I -
  H0503_RS00365 (STHERMO_0069) cinA 64183..65454 (+) 1272 WP_011680605.1 competence/damage-inducible protein A Machinery gene
  H0503_RS00370 (STHERMO_0070) recA 65490..66659 (+) 1170 WP_179970786.1 recombinase RecA Machinery gene
  H0503_RS00375 (STHERMO_0071) spx 66836..67234 (+) 399 WP_002949058.1 transcriptional regulator Spx -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45926.29 Da        Isoelectric Point: 5.0948

>NTDB_id=1130530 H0503_RS00365 WP_011680605.1 64183..65454(+) (cinA) [Streptococcus thermophilus isolate STH_CIRM_19]
MKAELIAVGTEILTGQITNTNAQFLSEKLAELGIDVYFHTAVGDNENRLLSVLDQSSKRSDLVILCGGLGPTEDDLTKQT
LAKFLGKELIFDEEASKKLDSFFATRPKHTRTPNNERQAQIVEGAVPLQNLTGLAVGGIITVEGVTYVVLPGPPSELKPM
VNQELIPALTENHTTLYSRVLRFFGVGESQLVTIIKDLIVNQTDPTIAPYAKVGEVTLRLSTKASSQEEADRKLDVLEEQ
IRSTKTLDGKSLSDLIYGYGESNSLAYEVFYLLKKYGKTITAAESLTAGLFQASVADFPGASQVFKGGFVTYSMEEKAKM
LGIPLSKLEEHGVVSHFTAEKMAEGARVKTDSDYGIALTGVAGPDALEGHQAGTVFIGIADRNQVRSIKVVIGGRSRSDV
RYISTLYAFNLVRQALLQEDNSI

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1130530 H0503_RS00365 WP_011680605.1 64183..65454(+) (cinA) [Streptococcus thermophilus isolate STH_CIRM_19]
ATGAAAGCTGAATTGATTGCAGTAGGAACTGAAATTCTTACAGGGCAAATCACCAATACCAATGCCCAATTTTTATCTGA
AAAACTAGCTGAATTAGGAATTGACGTGTATTTTCACACAGCGGTAGGAGACAATGAAAACCGTCTACTTTCAGTCTTAG
ACCAGTCTAGTAAACGTAGCGATTTAGTCATACTCTGTGGAGGACTTGGCCCTACTGAGGATGACCTAACCAAACAAACA
TTGGCTAAGTTTTTAGGCAAAGAACTCATTTTTGATGAGGAGGCAAGTAAAAAACTGGATAGTTTCTTTGCTACTCGTCC
TAAACATACACGAACGCCTAATAATGAACGCCAAGCGCAAATTGTTGAGGGGGCTGTCCCCTTGCAAAATCTCACAGGTC
TGGCAGTTGGAGGAATTATTACTGTTGAAGGAGTGACCTATGTTGTCTTGCCTGGTCCGCCAAGTGAACTCAAACCTATG
GTGAACCAAGAGCTTATTCCAGCTCTTACAGAGAATCATACTACGCTTTATTCTAGAGTCCTAAGGTTTTTTGGTGTTGG
AGAAAGTCAATTGGTGACTATTATTAAAGATCTCATTGTTAACCAAACAGACCCAACCATTGCGCCCTATGCTAAAGTGG
GAGAAGTGACCCTTCGCTTATCAACAAAGGCATCGTCGCAAGAAGAAGCGGATCGAAAACTAGATGTTTTAGAAGAACAA
ATTCGTTCTACTAAAACTCTAGATGGAAAAAGCTTGTCTGATCTCATCTATGGATATGGAGAATCAAATAGCTTAGCTTA
TGAAGTGTTCTATTTGCTTAAGAAATATGGCAAAACTATTACTGCAGCTGAAAGTTTAACAGCTGGCTTATTTCAAGCTA
GTGTTGCTGATTTTCCTGGAGCTTCACAAGTATTCAAGGGTGGTTTTGTCACCTATAGCATGGAAGAAAAAGCTAAAATG
TTGGGTATTCCCTTATCTAAATTAGAAGAGCATGGTGTTGTTAGTCATTTTACAGCAGAAAAAATGGCTGAGGGTGCCCG
AGTTAAGACAGATAGTGATTACGGAATTGCGCTTACTGGAGTAGCAGGACCAGATGCTTTGGAAGGGCATCAAGCAGGTA
CAGTCTTTATTGGTATTGCCGATAGAAACCAAGTGCGATCAATTAAGGTTGTTATAGGTGGAAGAAGTCGATCTGATGTT
AGATATATCAGTACACTCTATGCCTTTAACCTAGTTCGCCAAGCTTTATTACAAGAGGACAACTCAATTTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(264-415)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03MX6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

74.702

99.054

0.74
  cinA Streptococcus mitis NCTC 12261

73.508

99.054

0.728
  cinA Streptococcus pneumoniae TIGR4

72.315

99.054

0.716
  cinA Streptococcus pneumoniae Rx1

72.076

99.054

0.714
  cinA Streptococcus pneumoniae R6

72.076

99.054

0.714
  cinA Streptococcus pneumoniae D39

71.838

99.054

0.712
  cinA Streptococcus mutans UA159

70.309

99.527

0.7
  cinA Streptococcus suis isolate S10

54.567

98.345

0.537
  cinA Bacillus subtilis subsp. subtilis str. 168

44.656

99.527

0.444

Multiple sequence alignment