Detailed information NTG1127966

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FGL23_RS05250
• Genome accession: NZ_LR594049
• Coordinates: 1100614..1101288 (+)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain NCTC10231
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1095614..1106288

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL23_RS05225 (NCTC10231_01043)	-	1095639..1098182 (+)	2544	WP_061603939.1	M1 family metallopeptidase	-
FGL23_RS05230 (NCTC10231_01044)	-	1098365..1098649 (+)	285	WP_061600376.1	helix-turn-helix domain-containing protein	-
FGL23_RS05235 (NCTC10231_01045)	-	1098700..1099026 (+)	327	WP_008808733.1	DMT family transporter	-
FGL23_RS05240 (NCTC10231_01046)	-	1099041..1099844 (+)	804	WP_061603957.1	SDR family NAD(P)-dependent oxidoreductase	-
FGL23_RS05245 (NCTC10231_01047)	-	1100028..1100483 (+)	456	WP_008808731.1	hypothetical protein	-
FGL23_RS05250 (NCTC10231_01048)	ciaR	1100614..1101288 (+)	675	WP_008808730.1	response regulator transcription factor	Regulator
FGL23_RS05255 (NCTC10231_01049)	ciaH	1101278..1102684 (+)	1407	WP_045502826.1	sensor histidine kinase	Regulator
FGL23_RS05260 (NCTC10231_01050)	-	1102832..1104283 (-)	1452	WP_045502829.1	alpha-amylase	-
FGL23_RS05265 (NCTC10231_01051)	rpsT	1104514..1104762 (-)	249	WP_008808726.1	30S ribosomal protein S20	-
FGL23_RS05270 (NCTC10231_01052)	coaA	1104859..1105779 (-)	921	WP_008808725.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=1127966 FGL23_RS05250 WP_008808730.1 1100614..1101288(+) (ciaR) [Streptococcus gordonii strain NCTC10231]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=1127966 FGL23_RS05250 WP_008808730.1 1100614..1101288(+) (ciaR) [Streptococcus gordonii strain NCTC10231]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTCTATGAAGCCGAAAGCGGTGTTTATGATTTGATTTTACTTGATCTGATGC
TCCCTGAAAAAGATGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTAGATGATAAAGGGCATGGTTTTGAATTGGGTGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAAGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACCTTATCATATGGTGATGTAACAG
TAAACCTCTCTACCAATACCACATTGGTGAACGGAAAAGAAGTAGAATTACTAGGAAAAGAATTTGATTTATTAGTTTAT
TTCTTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGACTCTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362