Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FGL23_RS05255 Genome accession   NZ_LR594049
Coordinates   1101278..1102684 (+) Length   468 a.a.
NCBI ID   WP_045502826.1    Uniprot ID   A0AAW3H6B2
Organism   Streptococcus gordonii strain NCTC10231     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1096278..1107684
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL23_RS05230 (NCTC10231_01044) - 1098365..1098649 (+) 285 WP_061600376.1 helix-turn-helix domain-containing protein -
  FGL23_RS05235 (NCTC10231_01045) - 1098700..1099026 (+) 327 WP_008808733.1 DMT family transporter -
  FGL23_RS05240 (NCTC10231_01046) - 1099041..1099844 (+) 804 WP_061603957.1 SDR family NAD(P)-dependent oxidoreductase -
  FGL23_RS05245 (NCTC10231_01047) - 1100028..1100483 (+) 456 WP_008808731.1 hypothetical protein -
  FGL23_RS05250 (NCTC10231_01048) ciaR 1100614..1101288 (+) 675 WP_008808730.1 response regulator transcription factor Regulator
  FGL23_RS05255 (NCTC10231_01049) ciaH 1101278..1102684 (+) 1407 WP_045502826.1 sensor histidine kinase Regulator
  FGL23_RS05260 (NCTC10231_01050) - 1102832..1104283 (-) 1452 WP_045502829.1 alpha-amylase -
  FGL23_RS05265 (NCTC10231_01051) rpsT 1104514..1104762 (-) 249 WP_008808726.1 30S ribosomal protein S20 -
  FGL23_RS05270 (NCTC10231_01052) coaA 1104859..1105779 (-) 921 WP_008808725.1 type I pantothenate kinase -
  FGL23_RS05275 (NCTC10231_01053) - 1105885..1106478 (+) 594 WP_008808724.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 468 a.a.        Molecular weight: 53343.38 Da        Isoelectric Point: 9.3056

>NTDB_id=1127967 FGL23_RS05255 WP_045502826.1 1101278..1102684(+) (ciaH) [Streptococcus gordonii strain NCTC10231]
MLNKLRRTFYADDFSYFIRYFGVFTLIFSAMTLLIIQIMRSGLYTTVDDNLKSLSQNPRSVLHLALARAANMQPTIDEGQ
SSDDVSGPQDAPDPGPMDNLKVNSNTEAVLFDEDLKPLTTADHFLSLKKISIKKKDVGKIIQTTLKNNYGQEELYRMLVF
EINPSEFLSGNLLNKVKYAAVLINVNQLEQTSQNHEQIIIIVMISFWLISIIASIYLARVSVKPLMDSMQKQKSFVENAS
HELRTPLAVLQNRLETLFRKPEATIMESSENIASSLEEVRNMRMLTTNLLNLARRDDGIKAEIAEVEPEFFTTTFANYEI
IADENEKVFIYENHINHNIKTDRTLLKQLMTILFDNAVKYTEEDGIIKFIVWSKDRSLYLRVSDNGPGINNEDKKKIFDR
FYRVDKARTRQKGGFGLGLSLAKQIADALKGTITVKDNRPKGTIFEVKISIKSESKKRVGRLSDGKKD

Nucleotide


Download         Length: 1407 bp        

>NTDB_id=1127967 FGL23_RS05255 WP_045502826.1 1101278..1102684(+) (ciaH) [Streptococcus gordonii strain NCTC10231]
ATGCTGAATAAACTTAGACGAACTTTTTATGCGGATGATTTTTCATATTTCATTCGCTATTTTGGTGTATTCACACTTAT
TTTCTCGGCCATGACTCTTTTAATCATTCAGATTATGCGCTCAGGGCTTTATACAACAGTTGACGATAATTTAAAAAGTT
TAAGTCAGAATCCCAGATCTGTCCTCCACCTTGCTTTGGCTCGTGCAGCCAATATGCAACCAACGATTGATGAGGGTCAG
TCATCTGATGATGTATCTGGACCACAAGACGCACCAGACCCTGGACCAATGGATAATCTGAAGGTGAATTCGAACACTGA
AGCAGTCTTGTTTGATGAAGACTTGAAACCATTGACTACTGCAGATCATTTTCTTAGTTTAAAAAAGATTTCAATCAAGA
AAAAGGATGTAGGTAAAATTATTCAGACTACTTTGAAAAACAACTATGGTCAAGAAGAACTCTATCGTATGTTGGTTTTT
GAAATTAATCCAAGCGAATTCTTATCTGGGAATCTTTTGAACAAAGTAAAATATGCGGCAGTTTTGATCAATGTCAATCA
ATTGGAGCAAACCAGTCAGAATCATGAACAGATTATTATCATTGTTATGATTAGCTTTTGGTTAATCTCAATTATTGCTA
GTATCTATTTGGCTCGTGTCAGTGTGAAGCCTCTGATGGACAGTATGCAGAAACAAAAATCTTTTGTTGAAAATGCAAGC
CATGAGTTGCGTACTCCTTTAGCCGTTTTGCAAAACCGCTTGGAAACTCTTTTCCGAAAACCCGAAGCTACCATTATGGA
ATCAAGCGAAAATATTGCCTCCAGTCTGGAAGAAGTTCGGAATATGCGGATGCTAACAACTAATCTATTGAATCTTGCAA
GAAGAGATGATGGCATTAAGGCTGAAATTGCTGAAGTTGAACCAGAATTTTTCACTACAACATTTGCCAACTATGAAATC
ATTGCGGATGAAAATGAGAAAGTATTTATCTACGAAAATCATATCAACCACAACATCAAGACAGATAGAACACTTCTAAA
ACAGCTGATGACCATTCTATTTGATAATGCTGTGAAATATACAGAAGAAGATGGGATCATTAAGTTTATAGTATGGTCAA
AAGACCGTTCTCTTTACTTACGAGTGTCCGATAACGGCCCTGGAATCAATAATGAAGACAAAAAGAAAATTTTTGATCGT
TTTTATAGGGTTGATAAGGCCAGAACAAGACAAAAGGGTGGTTTTGGTCTAGGTCTATCTCTCGCAAAACAAATAGCCGA
TGCTCTAAAGGGTACAATTACTGTTAAAGATAATAGACCTAAAGGTACCATTTTTGAAGTCAAAATTTCCATCAAATCAG
AAAGTAAGAAACGAGTTGGACGATTGAGTGATGGAAAAAAAGATTGA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(342-449)

His Kinase A (phospho-acceptor) domain (HisKA)

(233-298)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

65.939

97.863

0.645
  ciaH Streptococcus pneumoniae D39

65.939

97.863

0.645
  ciaH Streptococcus pneumoniae R6

65.939

97.863

0.645
  ciaH Streptococcus pneumoniae TIGR4

65.939

97.863

0.645
  ciaH Streptococcus mutans UA159

54.788

95.94

0.526

Multiple sequence alignment