Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   FGL14_RS10715 Genome accession   NZ_LR594045
Coordinates   2134863..2136134 (-) Length   423 a.a.
NCBI ID   WP_138084081.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2136723..2200507 2134863..2136134 flank 589


Gene organization within MGE regions


Location: 2134863..2200507
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL14_RS10715 (NCTC9413_02214) cinA 2134863..2136134 (-) 1272 WP_138084081.1 competence/damage-inducible protein A Machinery gene
  FGL14_RS10720 (NCTC9413_02215) - 2136258..2136611 (-) 354 WP_003058738.1 VOC family protein -
  FGL14_RS10725 (NCTC9413_02216) - 2136614..2137186 (-) 573 WP_003058799.1 DNA-3-methyladenine glycosylase I -
  FGL14_RS10730 (NCTC9413_02217) ruvA 2137196..2137789 (-) 594 WP_003058778.1 Holliday junction branch migration protein RuvA -
  FGL14_RS10735 (NCTC9413_02218) - 2137791..2139011 (-) 1221 WP_138084082.1 MFS transporter -
  FGL14_RS10740 (NCTC9413_02219) mutL 2139022..2141004 (-) 1983 WP_138084083.1 DNA mismatch repair endonuclease MutL -
  FGL14_RS10745 (NCTC9413_02220) mutS 2141130..2143685 (-) 2556 WP_046177147.1 DNA mismatch repair protein MutS -
  FGL14_RS10750 (NCTC9413_02221) - 2143672..2144025 (-) 354 WP_003062220.1 YlbF family regulator -
  FGL14_RS10755 (NCTC9413_02222) argR 2144022..2144459 (-) 438 WP_138084084.1 arginine repressor -
  FGL14_RS10760 (NCTC9413_02223) argS 2144748..2146439 (+) 1692 WP_015017500.1 arginine--tRNA ligase -
  FGL14_RS10765 (NCTC9413_02224) - 2146509..2147906 (-) 1398 WP_014612639.1 ATP-binding cassette domain-containing protein -
  FGL14_RS10770 (NCTC9413_02225) - 2148083..2148997 (-) 915 WP_003055540.1 YitT family protein -
  FGL14_RS10775 (NCTC9413_02226) - 2149027..2149926 (-) 900 WP_003060132.1 YitT family protein -
  FGL14_RS10780 (NCTC9413_02227) - 2149947..2150888 (-) 942 WP_003055524.1 YitT family protein -
  FGL14_RS10785 (NCTC9413_02228) aspS 2150881..2152629 (-) 1749 WP_003055520.1 aspartate--tRNA ligase -
  FGL14_RS10790 (NCTC9413_02229) hisS 2152967..2154247 (-) 1281 WP_037589972.1 histidine--tRNA ligase -
  FGL14_RS10795 (NCTC9413_02230) rpmF 2154637..2154819 (+) 183 WP_000290414.1 50S ribosomal protein L32 -
  FGL14_RS10800 (NCTC9413_02231) rpmG 2154835..2154984 (+) 150 WP_002982147.1 50S ribosomal protein L33 -
  FGL14_RS11575 - 2155024..2155248 (-) 225 WP_072353678.1 FanG protein -
  FGL14_RS10810 (NCTC9413_02232) - 2155277..2155891 (+) 615 WP_000615740.1 CadD family cadmium resistance transporter -
  FGL14_RS10815 (NCTC9413_02233) cadX 2155903..2156241 (+) 339 WP_000711091.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  FGL14_RS10820 (NCTC9413_02234) - 2156285..2157700 (+) 1416 WP_021775548.1 helix-turn-helix transcriptional regulator -
  FGL14_RS10825 (NCTC9413_02235) - 2158022..2158471 (+) 450 WP_000066866.1 sigma factor-like helix-turn-helix DNA-binding protein -
  FGL14_RS10830 (NCTC9413_02236) - 2158673..2158993 (+) 321 WP_000874691.1 hypothetical protein -
  FGL14_RS10835 (NCTC9413_02237) - 2158993..2160093 (+) 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
  FGL14_RS10840 (NCTC9413_02238) - 2160090..2160695 (+) 606 WP_000208936.1 hypothetical protein -
  FGL14_RS10845 (NCTC9413_02239) - 2160894..2161499 (+) 606 WP_001040933.1 replication protein -
  FGL14_RS10850 (NCTC9413_02240) - 2161492..2161740 (+) 249 WP_003055530.1 MerR family transcriptional regulator -
  FGL14_RS10855 (NCTC9413_02241) - 2161829..2163094 (+) 1266 WP_136118485.1 site-specific integrase -
  FGL14_RS10860 (NCTC9413_02242) - 2163390..2166881 (-) 3492 WP_138084085.1 hypothetical protein -
  FGL14_RS10865 (NCTC9413_02243) - 2167147..2167989 (+) 843 WP_015017505.1 DUF368 domain-containing protein -
  FGL14_RS10870 (NCTC9413_02244) - 2168072..2168326 (-) 255 WP_242002710.1 thioredoxin family protein -
  FGL14_RS10875 (NCTC9413_02245) - 2168474..2169088 (-) 615 WP_044565657.1 CoA pyrophosphatase -
  FGL14_RS10880 (NCTC9413_02246) - 2169292..2169618 (+) 327 WP_003059571.1 PadR family transcriptional regulator -
  FGL14_RS10885 (NCTC9413_02247) - 2169605..2170192 (+) 588 WP_003060115.1 DUF1700 domain-containing protein -
  FGL14_RS10890 (NCTC9413_02248) - 2170189..2171262 (+) 1074 WP_138084087.1 DUF4097 family beta strand repeat-containing protein -
  FGL14_RS10895 (NCTC9413_02249) - 2171387..2173660 (-) 2274 WP_115283540.1 YhgE/Pip domain-containing protein -
  FGL14_RS10900 (NCTC9413_02250) - 2173795..2174328 (+) 534 WP_003059589.1 TetR/AcrR family transcriptional regulator -
  FGL14_RS10905 (NCTC9413_02251) - 2174384..2175826 (-) 1443 WP_138084088.1 IS1182 family transposase -
  FGL14_RS10910 (NCTC9413_02252) rpsD 2176034..2176645 (-) 612 WP_003053152.1 30S ribosomal protein S4 -
  FGL14_RS10915 (NCTC9413_02253) - 2176834..2177301 (-) 468 WP_003055134.1 helix-turn-helix transcriptional regulator -
  FGL14_RS10920 (NCTC9413_02254) - 2177454..2177726 (-) 273 WP_003055136.1 Veg family protein -
  FGL14_RS10925 (NCTC9413_02255) dnaB 2177742..2179103 (-) 1362 WP_041789162.1 replicative DNA helicase -
  FGL14_RS10930 (NCTC9413_02256) rplI 2179139..2179591 (-) 453 WP_046177822.1 50S ribosomal protein L9 -
  FGL14_RS10935 (NCTC9413_02257) - 2179588..2181564 (-) 1977 WP_015058169.1 DHH family phosphoesterase -
  FGL14_RS10940 (NCTC9413_02258) mnmG 2181655..2183553 (-) 1899 WP_065957511.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
  FGL14_RS10945 (NCTC9413_02259) - 2183605..2184054 (-) 450 WP_242002711.1 NUDIX domain-containing protein -
  FGL14_RS10950 (NCTC9413_02260) - 2184268..2184876 (-) 609 WP_111681939.1 MarC family protein -
  FGL14_RS10955 (NCTC9413_02261) mnmA 2184908..2186029 (-) 1122 WP_003055143.1 tRNA 2-thiouridine(34) synthase MnmA -
  FGL14_RS10960 (NCTC9413_02262) sdaAB 2186326..2186997 (+) 672 WP_003055144.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -
  FGL14_RS10965 (NCTC9413_02263) sdaAA 2187009..2187881 (+) 873 WP_003055113.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  FGL14_RS10970 (NCTC9413_02264) - 2187907..2188554 (+) 648 WP_138084089.1 HAD hydrolase-like protein -
  FGL14_RS10975 (NCTC9413_02265) - 2188617..2189231 (-) 615 WP_138084090.1 transglycosylase SLT domain-containing protein -
  FGL14_RS10980 (NCTC9413_02266) - 2189424..2190224 (-) 801 WP_138084091.1 energy-coupling factor transporter transmembrane protein EcfT -
  FGL14_RS10985 (NCTC9413_02267) - 2190217..2191059 (-) 843 WP_003055138.1 energy-coupling factor ABC transporter ATP-binding protein -
  FGL14_RS10990 (NCTC9413_02268) - 2191035..2191874 (-) 840 WP_003055130.1 energy-coupling factor ABC transporter ATP-binding protein -
  FGL14_RS10995 (NCTC9413_02269) pgsA 2191877..2192419 (-) 543 WP_003062173.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  FGL14_RS11000 (NCTC9413_02270) - 2192433..2193464 (-) 1032 WP_003061371.1 helix-turn-helix domain-containing protein -
  FGL14_RS11005 (NCTC9413_02271) - 2193514..2194797 (-) 1284 WP_065956901.1 pitrilysin family protein -
  FGL14_RS11010 (NCTC9413_02272) - 2194799..2196043 (-) 1245 WP_138084092.1 pitrilysin family protein -
  FGL14_RS11015 (NCTC9413_02273) yaaA 2196352..2196765 (+) 414 WP_138084093.1 S4 domain-containing protein YaaA -
  FGL14_RS11020 (NCTC9413_02274) recF 2196767..2197873 (+) 1107 WP_138084094.1 DNA replication/repair protein RecF -
  FGL14_RS11025 (NCTC9413_02275) - 2197930..2198793 (-) 864 WP_003055126.1 GRP family sugar transporter -
  FGL14_RS11030 (NCTC9413_02276) guaB 2199005..2200486 (-) 1482 WP_003060436.1 IMP dehydrogenase -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46025.44 Da        Isoelectric Point: 4.7637

>NTDB_id=1127766 FGL14_RS10715 WP_138084081.1 2134863..2136134(-) (cinA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413]
MKAELITVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVIATASQRSDLVILCGGLGPTEDDLTKQT
LAKYLNRDLVFEEQASQKLDAFYASRKESSRTANNAKQAQIIAGSSPLQNRTGLAVGGLITVNEVTYVVLPGPPSELKPM
VNEELLPFLSTQSRKLYSRVLRFFGIGESQLVTVLSDLIENQTDPTIAPYAKTGEVTLRLSTKAENQTLADTKLDPLEAQ
LLSRKTPDNQSLSDFLYGYREDNSLAREVFELLVKYDKTITAAESLTAGLFQSTLASFSGASQVFNGGFVTYSMEEKARM
LGIPLEDLISHGVVSAYTAEKMAEQARLLTGADIGVSLTGVAGPDMMEEQPAGTVFIGLATQNKVESIKVLISGRSRSDV
RHIATLHAFNMVRKTLLKPENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1127766 FGL14_RS10715 WP_138084081.1 2134863..2136134(-) (cinA) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC9413]
ATGAAAGCTGAACTGATTACAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGATAACGAGGAGCGTTTACTTTCAGTGATTG
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGTCTTGGCCCCACGGAAGATGATTTAACCAAGCAGACT
TTAGCAAAATATCTTAATAGAGATTTGGTCTTTGAAGAACAAGCTAGTCAAAAATTGGACGCTTTTTATGCTAGTCGTAA
AGAGTCGTCTCGAACGGCAAATAATGCTAAGCAGGCTCAAATCATTGCTGGTTCAAGCCCTCTGCAAAATAGAACAGGAC
TTGCAGTGGGTGGCTTAATCACTGTTAATGAGGTGACTTATGTTGTTTTACCCGGGCCGCCAAGTGAATTAAAACCTATG
GTTAATGAGGAACTGCTTCCTTTTTTGTCCACACAATCTCGCAAACTTTATTCGAGAGTTTTACGATTTTTTGGGATTGG
TGAGAGTCAGCTGGTGACGGTCTTATCAGACCTTATTGAGAATCAAACTGATCCTACTATTGCACCTTATGCCAAAACTG
GTGAAGTGACCCTTCGTTTATCAACGAAAGCTGAAAATCAAACATTAGCAGATACGAAATTAGATCCACTAGAAGCGCAG
CTATTGTCGCGAAAAACTCCTGACAACCAGTCGTTATCAGATTTTCTTTATGGCTATAGGGAGGATAATTCCTTAGCGCG
TGAGGTATTTGAGCTCTTAGTAAAATATGATAAGACAATTACTGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTTCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAGAATG
CTAGGCATTCCTTTAGAGGATTTGATATCGCATGGAGTTGTTAGTGCTTATACGGCCGAGAAGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGATGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGCCGTTCAGATGTG
CGTCATATTGCGACTTTACATGCTTTTAATATGGTCCGTAAAACTTTATTAAAACCTGAAAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

72.34

100

0.723
  cinA Streptococcus mitis SK321

70.743

98.582

0.697
  cinA Streptococcus mitis NCTC 12261

69.784

98.582

0.688
  cinA Streptococcus pneumoniae TIGR4

69.544

98.582

0.686
  cinA Streptococcus pneumoniae Rx1

69.544

98.582

0.686
  cinA Streptococcus pneumoniae R6

69.544

98.582

0.686
  cinA Streptococcus pneumoniae D39

69.305

98.582

0.683
  cinA Streptococcus suis isolate S10

52.644

98.345

0.518
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

98.818

0.449

Multiple sequence alignment