Detailed information NTG1127492

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FGL12_RS05300
• Genome accession: NZ_LR594041
• Coordinates: 1091112..1091786 (+)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain NCTC9124
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1086112..1096786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL12_RS05275 (NCTC9124_01060)	-	1086408..1086704 (+)	297	WP_012000479.1	hypothetical protein	-
FGL12_RS05280 (NCTC9124_01061)	-	1086713..1087039 (+)	327	WP_012000480.1	hypothetical protein	-
FGL12_RS05285 (NCTC9124_01062)	-	1087170..1089713 (+)	2544	WP_012000481.1	M1 family metallopeptidase	-
FGL12_RS05290 (NCTC9124_01063)	-	1089770..1090312 (-)	543	WP_012000482.1	biotin transporter BioY	-
FGL12_RS05295 (NCTC9124_01064)	-	1090526..1090981 (+)	456	WP_138101203.1	hypothetical protein	-
FGL12_RS05300 (NCTC9124_01065)	ciaR	1091112..1091786 (+)	675	WP_008808730.1	response regulator transcription factor	Regulator
FGL12_RS05305 (NCTC9124_01066)	ciaH	1091776..1093176 (+)	1401	WP_138101204.1	HAMP domain-containing sensor histidine kinase	Regulator
FGL12_RS05310 (NCTC9124_01067)	-	1093178..1094104 (+)	927	WP_045773978.1	2-dehydropantoate 2-reductase N-terminal domain-containing protein	-
FGL12_RS05315 (NCTC9124_01068)	-	1094128..1095579 (-)	1452	WP_045773979.1	alpha-amylase	-
FGL12_RS05320 (NCTC9124_01069)	rpsT	1095810..1096058 (-)	249	WP_008808726.1	30S ribosomal protein S20	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=1127492 FGL12_RS05300 WP_008808730.1 1091112..1091786(+) (ciaR) [Streptococcus gordonii strain NCTC9124]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=1127492 FGL12_RS05300 WP_008808730.1 1091112..1091786(+) (ciaR) [Streptococcus gordonii strain NCTC9124]
ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATCTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGATGGCTTTCAAGTTTTGAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGAGCTGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAATAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362