Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   FGL12_RS05305 Genome accession   NZ_LR594041
Coordinates   1091776..1093176 (+) Length   466 a.a.
NCBI ID   WP_138101204.1    Uniprot ID   -
Organism   Streptococcus gordonii strain NCTC9124     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1086776..1098176
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL12_RS05285 (NCTC9124_01062) - 1087170..1089713 (+) 2544 WP_012000481.1 M1 family metallopeptidase -
  FGL12_RS05290 (NCTC9124_01063) - 1089770..1090312 (-) 543 WP_012000482.1 biotin transporter BioY -
  FGL12_RS05295 (NCTC9124_01064) - 1090526..1090981 (+) 456 WP_138101203.1 hypothetical protein -
  FGL12_RS05300 (NCTC9124_01065) ciaR 1091112..1091786 (+) 675 WP_008808730.1 response regulator transcription factor Regulator
  FGL12_RS05305 (NCTC9124_01066) ciaH 1091776..1093176 (+) 1401 WP_138101204.1 HAMP domain-containing sensor histidine kinase Regulator
  FGL12_RS05310 (NCTC9124_01067) - 1093178..1094104 (+) 927 WP_045773978.1 2-dehydropantoate 2-reductase N-terminal domain-containing protein -
  FGL12_RS05315 (NCTC9124_01068) - 1094128..1095579 (-) 1452 WP_045773979.1 alpha-amylase -
  FGL12_RS05320 (NCTC9124_01069) rpsT 1095810..1096058 (-) 249 WP_008808726.1 30S ribosomal protein S20 -
  FGL12_RS05325 (NCTC9124_01070) coaA 1096155..1097075 (-) 921 WP_138101205.1 type I pantothenate kinase -
  FGL12_RS05330 (NCTC9124_01071) - 1097181..1097774 (+) 594 WP_053794626.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 466 a.a.        Molecular weight: 53020.05 Da        Isoelectric Point: 9.4441

>NTDB_id=1127493 FGL12_RS05305 WP_138101204.1 1091776..1093176(+) (ciaH) [Streptococcus gordonii strain NCTC9124]
MLNKLRRTLYADDFSYFIRYFGVFTLIFSAMTLLIIQIMRSGLYTTVDDNLKSLSQNPRSVLHLALARAANMQPTIDEGQ
PSDDESGPQNAPDPGPMDNLKVNSNTEAVLFDEGLKPLTTADHFLSLKTISIKKKDVGKIIQINLKNNYGQEELYRMLVF
EINPSEFLSGNLLNKVKYAAVLINVNQLEQTSQNHEQIIVIVMISFWLISIIASIYLARVSVKPLIDSMQKQKSFVENAS
HELRTPLAVLQNRLETLFRKPEATIMESSENIASSLEEVRNMRMLTTNLLNLARRDDGIKAEFAEVEPEFFTTTFANYEI
IADENEKAFVYENHINHNIKTDRTLLKQLMTILFDNAVKYTEEDGIIKFIVWSKDRSLYLRVSDNGPGINNEDKKKIFDR
FYRVDKARTRQKGGFGLGLSLAKQIADALKGTITVKDNRPKGTIFEIKISIKSESKKKSTKLIGNK

Nucleotide


Download         Length: 1401 bp        

>NTDB_id=1127493 FGL12_RS05305 WP_138101204.1 1091776..1093176(+) (ciaH) [Streptococcus gordonii strain NCTC9124]
ATGCTGAATAAACTTAGACGAACTTTATATGCGGATGATTTTTCATATTTCATTCGCTATTTTGGTGTATTCACACTTAT
TTTCTCGGCTATGACTCTTTTAATCATTCAAATTATGCGCTCAGGGCTCTATACAACCGTTGACGATAATTTAAAAAGTT
TAAGTCAGAATCCCAGATCTGTCCTCCATCTTGCTCTGGCTCGTGCAGCTAATATGCAACCAACGATTGATGAAGGCCAG
CCATCCGATGATGAATCTGGACCACAAAACGCACCAGATCCTGGACCAATGGATAATCTGAAGGTGAATTCGAACACTGA
AGCAGTCTTGTTTGATGAAGGATTGAAACCATTGACTACTGCAGATCATTTTCTTAGTTTAAAAACGATTTCAATCAAGA
AAAAGGATGTTGGTAAAATTATTCAGATTAATTTGAAAAACAACTATGGACAAGAAGAACTGTATCGTATGTTGGTTTTT
GAAATTAATCCAAGCGAATTCTTATCTGGGAATCTTTTGAACAAAGTAAAATATGCAGCAGTTTTGATTAATGTCAATCA
ATTGGAGCAAACCAGTCAGAATCATGAACAAATCATTGTCATTGTTATGATTAGTTTCTGGTTAATTTCAATTATTGCCA
GTATTTATTTGGCTCGGGTCAGTGTGAAGCCTCTAATAGACAGTATGCAGAAGCAAAAATCTTTTGTTGAAAACGCCAGC
CATGAGTTGCGTACTCCATTAGCTGTTTTGCAGAACCGTTTGGAAACTCTTTTCCGAAAACCGGAAGCTACGATTATGGA
ATCTAGTGAAAATATTGCCTCCAGTCTGGAAGAAGTTCGGAATATGAGGATGCTAACAACTAATCTATTGAATCTTGCAA
GAAGAGATGATGGCATTAAGGCTGAATTTGCTGAAGTTGAACCAGAATTTTTCACTACAACATTTGCTAACTACGAAATC
ATTGCGGATGAAAACGAGAAAGCATTTGTCTACGAAAACCATATTAACCACAATATCAAGACAGACAGAACACTTCTAAA
ACAGCTGATGACTATTCTCTTTGATAATGCTGTGAAATATACAGAAGAAGATGGGATCATTAAGTTTATAGTATGGTCAA
AAGACCGTTCTCTTTACTTACGAGTGTCTGATAACGGACCTGGAATCAATAATGAAGACAAAAAGAAAATTTTTGATCGT
TTTTATAGGGTTGATAAAGCCAGAACTAGGCAAAAGGGTGGTTTTGGTCTAGGTCTATCCCTTGCAAAACAAATAGCCGA
TGCTCTAAAGGGTACAATTACTGTTAAAGATAATAGACCGAAAGGTACCATTTTTGAGATCAAAATTTCCATTAAATCAG
AAAGCAAGAAAAAATCAACTAAGCTAATAGGAAATAAATGA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(342-449)

His Kinase A (phospho-acceptor) domain (HisKA)

(233-298)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

65.721

98.283

0.646
  ciaH Streptococcus pneumoniae D39

65.721

98.283

0.646
  ciaH Streptococcus pneumoniae R6

65.721

98.283

0.646
  ciaH Streptococcus pneumoniae TIGR4

65.721

98.283

0.646
  ciaH Streptococcus mutans UA159

54.12

96.352

0.521

Multiple sequence alignment