Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   FGK81_RS00580 Genome accession   NZ_LR590466
Coordinates   108446..109717 (+) Length   423 a.a.
NCBI ID   WP_011018313.1    Uniprot ID   A2RGU9
Organism   Streptococcus pyogenes strain NCTC8193     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 92822..120342 108446..109717 within 0


Gene organization within MGE regions


Location: 92822..120342
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK81_RS00475 (NCTC8193_00095) - 92822..93205 (-) 384 WP_011889235.1 ArpU family phage packaging/lysis transcriptional regulator -
  FGK81_RS00480 (NCTC8193_00096) - 93180..93542 (-) 363 WP_011889234.1 DUF1492 domain-containing protein -
  FGK81_RS00490 (NCTC8193_00097) - 93946..94434 (-) 489 WP_011889233.1 hypothetical protein -
  FGK81_RS00495 (NCTC8193_00098) - 94508..95065 (-) 558 WP_023077351.1 hypothetical protein -
  FGK81_RS09775 (NCTC8193_00099) - 95067..95240 (-) 174 WP_011529113.1 hypothetical protein -
  FGK81_RS00500 (NCTC8193_00100) - 95246..95419 (-) 174 WP_011889231.1 hypothetical protein -
  FGK81_RS00505 (NCTC8193_00101) - 95733..97235 (-) 1503 WP_011889230.1 DNA primase family protein -
  FGK81_RS00510 (NCTC8193_00102) - 97255..98121 (-) 867 WP_011889229.1 primase alpha helix C-terminal domain-containing protein -
  FGK81_RS00515 (NCTC8193_00103) - 98122..98394 (-) 273 WP_011889228.1 hypothetical protein -
  FGK81_RS00520 (NCTC8193_00104) - 98397..98726 (-) 330 WP_003045763.1 hypothetical protein -
  FGK81_RS00525 (NCTC8193_00105) - 98738..98929 (-) 192 WP_011889227.1 hypothetical protein -
  FGK81_RS00530 (NCTC8193_00106) - 98929..99261 (-) 333 WP_011889226.1 hypothetical protein -
  FGK81_RS00535 (NCTC8193_00107) - 99555..99788 (-) 234 WP_011889225.1 helix-turn-helix domain-containing protein -
  FGK81_RS10170 - 99943..100180 (+) 238 Protein_88 helix-turn-helix domain-containing protein -
  FGK81_RS00545 (NCTC8193_00109) - 101250..101525 (+) 276 WP_011889223.1 helix-turn-helix transcriptional regulator -
  FGK81_RS00550 (NCTC8193_00110) - 101551..102540 (+) 990 WP_011889222.1 DUF3644 domain-containing protein -
  FGK81_RS00555 (NCTC8193_00112) - 102884..103901 (+) 1018 Protein_91 tyrosine-type recombinase/integrase -
  FGK81_RS00560 (NCTC8193_00113) mutL 103996..105978 (+) 1983 WP_011889221.1 DNA mismatch repair endonuclease MutL -
  FGK81_RS00565 (NCTC8193_00114) - 105989..107209 (+) 1221 WP_011018316.1 MDR family MFS transporter -
  FGK81_RS00570 (NCTC8193_00115) ruvA 107211..107807 (+) 597 WP_011185063.1 Holliday junction branch migration protein RuvA -
  FGK81_RS00575 (NCTC8193_00116) - 107817..108377 (+) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  FGK81_RS00580 (NCTC8193_00117) cinA 108446..109717 (+) 1272 WP_011018313.1 competence/damage-inducible protein A Machinery gene
  FGK81_RS00585 (NCTC8193_00118) recA 109806..110942 (+) 1137 WP_002982186.1 recombinase RecA Machinery gene
  FGK81_RS00590 (NCTC8193_00119) spx 111233..111631 (+) 399 WP_002982188.1 transcriptional regulator Spx -
  FGK81_RS00595 (NCTC8193_00120) - 111744..112013 (+) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  FGK81_RS00600 (NCTC8193_00121) ruvX 112010..112429 (+) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  FGK81_RS00605 (NCTC8193_00122) - 112441..112746 (+) 306 WP_002982199.1 DUF1292 domain-containing protein -
  FGK81_RS00610 (NCTC8193_00124) - 113159..114718 (+) 1560 WP_002992833.1 membrane protein -
  FGK81_RS00615 (NCTC8193_00125) nrdD 114815..117013 (+) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  FGK81_RS09780 (NCTC8193_00126) - 117195..117341 (+) 147 WP_002982210.1 hypothetical protein -
  FGK81_RS00620 (NCTC8193_00127) - 117370..118305 (+) 936 WP_011889220.1 Gfo/Idh/MocA family protein -
  FGK81_RS00625 (NCTC8193_00128) - 118314..118823 (+) 510 WP_002991345.1 GNAT family N-acetyltransferase -
  FGK81_RS00630 (NCTC8193_00129) nrdG 118823..119437 (+) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  FGK81_RS00635 (NCTC8193_00130) yaaA 119611..120342 (-) 732 WP_011889219.1 peroxide stress protein YaaA -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45908.59 Da        Isoelectric Point: 4.7648

>NTDB_id=1126763 FGK81_RS00580 WP_011018313.1 108446..109717(+) (cinA) [Streptococcus pyogenes strain NCTC8193]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKSM
VNEELVPLLSKQYSTLYSKVLRFFGVGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGQSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1126763 FGK81_RS00580 WP_011018313.1 108446..109717(+) (cinA) [Streptococcus pyogenes strain NCTC8193]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGTCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTGTTGG
GGAAAGTCAGTTGGTAACAGTTTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCAAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RGU9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

68.794

100

0.688
  cinA Streptococcus mitis SK321

69.065

98.582

0.681
  cinA Streptococcus mitis NCTC 12261

68.585

98.582

0.676
  cinA Streptococcus pneumoniae TIGR4

67.626

98.582

0.667
  cinA Streptococcus pneumoniae Rx1

67.626

98.582

0.667
  cinA Streptococcus pneumoniae R6

67.626

98.582

0.667
  cinA Streptococcus pneumoniae D39

67.386

98.582

0.664
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456

Multiple sequence alignment