Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   E0F32_RS11180 Genome accession   NZ_LR216050
Coordinates   2057185..2058366 (+) Length   393 a.a.
NCBI ID   WP_000681601.1    Uniprot ID   A0A0B7LRW6
Organism   Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2052185..2063366
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F32_RS11140 (SAMEA3431333_02090) - 2053236..2053778 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  E0F32_RS11155 (SAMEA3431333_02093) comE 2054021..2054773 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  E0F32_RS11160 (SAMEA3431333_02094) comD/comD2 2054770..2056095 (-) 1326 WP_001842237.1 competence system sensor histidine kinase ComD Regulator
  E0F32_RS11165 (SAMEA3431333_02095) comC/comC2 2056116..2056241 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  E0F32_RS11175 (SAMEA3431333_02097) rlmH 2056523..2057002 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E0F32_RS11180 (SAMEA3431333_02098) htrA 2057185..2058366 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  E0F32_RS11185 (SAMEA3431333_02099) spo0J 2058424..2059182 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator
  E0F32_RS11190 (SAMEA3431333_02100) dnaA 2059395..2060756 (+) 1362 WP_000660618.1 chromosomal replication initiator protein DnaA -
  E0F32_RS11195 (SAMEA3431333_02101) dnaN 2060915..2062051 (+) 1137 WP_000581157.1 DNA polymerase III subunit beta -
  E0F32_RS11200 (SAMEA3431333_02102) - 2062116..2062310 (+) 195 WP_000285194.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41855.70 Da        Isoelectric Point: 6.8902

>NTDB_id=1126161 E0F32_RS11180 WP_000681601.1 2057185..2058366(+) (htrA) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=1126161 E0F32_RS11180 WP_000681601.1 2057185..2058366(+) (htrA) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LRW6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.491

100

0.995
  htrA Streptococcus pneumoniae D39

99.491

100

0.995
  htrA Streptococcus pneumoniae R6

99.491

100

0.995
  htrA Streptococcus pneumoniae TIGR4

99.491

100

0.995
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.919

100

0.674
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment