Detailed information NTG1126159

Bioinformatically predicted

Overview

• Name: comD/comD2
• Type: Regulator
• Locus tag: E0F32_RS11160
• Genome accession: NZ_LR216050
• Coordinates: 2054770..2056095 (-)
• Length: 441 a.a.
• NCBI ID: WP_001842237.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505
• Function: phosphorylation of ComE (predicted from homology) Competence regulation

Genomic Context

Location: 2049770..2061095

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0F32_RS12320	-	2051454..2053057 (-)	1604	Protein_2074	YhgE/Pip family protein	-
E0F32_RS11140 (SAMEA3431333_02090)	-	2053236..2053778 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
E0F32_RS11155 (SAMEA3431333_02093)	comE	2054021..2054773 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
E0F32_RS11160 (SAMEA3431333_02094)	comD/comD2	2054770..2056095 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
E0F32_RS11165 (SAMEA3431333_02095)	comC/comC2	2056116..2056241 (-)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
E0F32_RS11175 (SAMEA3431333_02097)	rlmH	2056523..2057002 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
E0F32_RS11180 (SAMEA3431333_02098)	htrA	2057185..2058366 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
E0F32_RS11185 (SAMEA3431333_02099)	spo0J	2058424..2059182 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator
E0F32_RS11190 (SAMEA3431333_02100)	dnaA	2059395..2060756 (+)	1362	WP_000660618.1	chromosomal replication initiator protein DnaA	-

Sequence

Protein

• Length: 441 a.a.
• Molecular weight: 51441.05 Da
• Isoelectric Point: 7.5816

>NTDB_id=1126159 E0F32_RS11160 WP_001842237.1 2054770..2056095(-) (comD/comD2) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide

• Length: 1326 bp

>NTDB_id=1126159 E0F32_RS11160 WP_001842237.1 2054770..2056095(-) (comD/comD2) [Streptococcus pneumoniae strain GPSC10 substr. ST2013 isolate GPS_US_PATH396-sc-2296505]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

• GHKL domain (HATPase_c_5) (334-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/comD2	Streptococcus pneumoniae TIGR4	99.546	100	0.995
comD/comD1	Streptococcus pneumoniae Rx1	96.825	100	0.968
comD/comD1	Streptococcus pneumoniae D39	96.825	100	0.968
comD/comD1	Streptococcus pneumoniae R6	96.825	100	0.968
comD	Streptococcus mitis SK321	92.063	100	0.921
comD	Streptococcus mitis NCTC 12261	86.621	100	0.866
comD/comD2	Streptococcus gordonii strain NCTC7865	49.202	85.261	0.42
comD/comD1	Streptococcus gordonii str. Challis substr. CH1	49.465	84.807	0.419