Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   EL135_RS12760 Genome accession   NZ_LR134312
Coordinates   2558623..2559867 (-) Length   414 a.a.
NCBI ID   WP_002354857.1    Uniprot ID   A0A3N3PE98
Organism   Enterococcus faecalis strain NCTC8745     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 2553623..2564867
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL135_RS12735 (NCTC8745_02465) - 2554094..2554465 (-) 372 WP_002354866.1 YlbF family regulator -
  EL135_RS12740 (NCTC8745_02466) - 2554553..2555350 (-) 798 WP_002354864.1 TIGR00282 family metallophosphoesterase -
  EL135_RS12745 (NCTC8745_02467) rny 2555510..2557066 (-) 1557 WP_002354863.1 ribonuclease Y -
  EL135_RS12755 (NCTC8745_02468) recA 2557463..2558509 (-) 1047 WP_002354860.1 recombinase RecA Machinery gene
  EL135_RS12760 (NCTC8745_02469) cinA 2558623..2559867 (-) 1245 WP_002354857.1 competence/damage-inducible protein A Machinery gene
  EL135_RS12765 (NCTC8745_02470) - 2560059..2561258 (+) 1200 WP_002354856.1 hypothetical protein -
  EL135_RS12770 (NCTC8745_02471) - 2561338..2561967 (-) 630 WP_002354854.1 NAD(P)-dependent oxidoreductase -
  EL135_RS12775 (NCTC8745_02472) - 2562026..2562451 (-) 426 WP_002383201.1 Rrf2 family transcriptional regulator -
  EL135_RS12780 (NCTC8745_02473) - 2562540..2562923 (-) 384 WP_002354850.1 YccF domain-containing protein -
  EL135_RS12785 (NCTC8745_02474) - 2563087..2563878 (+) 792 WP_002367471.1 hypothetical protein -

Sequence

Protein


Download         Length: 414 a.a.        Molecular weight: 45192.30 Da        Isoelectric Point: 4.7172

>NTDB_id=1121077 EL135_RS12760 WP_002354857.1 2558623..2559867(-) (cinA) [Enterococcus faecalis strain NCTC8745]
MKAEIIAVGTELLLGQVVNTNATFLSEELAALGIDVYYQTVVGDNGGRLETLLTEAEQRSDLIVLCGGLGPTEDDLTKQV
VAQHLHKSLVEDQEGLNRLHQFFQQSKRPMTENNLRQVLAIEGGQVLQNPTGLAVGSFVTEGTTSYLLLPGPPNELIPMF
QQAARPLLINAFPQEEQLISRVLRFYGIGESQLVTEIQSLIAHQTNPTIAPYAKPNEVTLRLTVKTKDLVAGEELLTATE
EKVLAKVGDYFYGYGDDNSLAKVTVDLLLQNGQTVTAAESLTAGLFQSTLGEIAGASKIFKGGFVTYSQETKENFLGISH
ELLEEHGTVSEACAKEMAEKARQLAKSNYGLSFTGVAGDPIEGQPTGTVWIGLAEEGQPTVAECFHFNRDRNYIRQSAVM
RGLDLLRRRIINKK

Nucleotide


Download         Length: 1245 bp        

>NTDB_id=1121077 EL135_RS12760 WP_002354857.1 2558623..2559867(-) (cinA) [Enterococcus faecalis strain NCTC8745]
ATGAAAGCAGAAATCATTGCAGTCGGAACAGAGTTATTACTGGGACAAGTAGTGAATACCAACGCCACCTTTTTATCAGA
AGAGTTAGCTGCGCTAGGCATCGATGTTTACTATCAGACCGTTGTTGGCGATAACGGCGGCCGCTTAGAAACGCTACTAA
CAGAAGCAGAACAAAGAAGTGATTTAATTGTCCTTTGTGGAGGGCTAGGACCTACAGAAGACGATTTAACCAAGCAAGTT
GTCGCACAACATCTCCATAAATCATTAGTAGAAGATCAAGAAGGATTGAACCGCTTACACCAGTTTTTCCAACAGTCTAA
GCGGCCAATGACGGAAAATAATCTACGACAAGTGTTAGCCATTGAAGGTGGACAAGTTCTTCAAAACCCGACAGGATTAG
CGGTTGGTTCTTTCGTAACAGAAGGCACAACAAGCTATTTGCTCTTACCAGGGCCGCCCAATGAATTAATTCCGATGTTT
CAACAAGCGGCACGACCTTTATTGATTAATGCGTTTCCACAAGAAGAACAATTGATTTCAAGAGTCTTGCGTTTTTATGG
CATTGGTGAATCACAGCTGGTGACCGAGATTCAATCGTTGATTGCGCACCAAACGAATCCAACCATTGCGCCTTATGCTA
AGCCTAATGAAGTGACACTTCGTTTAACAGTTAAAACAAAAGACTTAGTAGCTGGCGAAGAATTATTAACAGCGACGGAA
GAAAAGGTTTTAGCTAAAGTGGGAGACTATTTTTATGGGTATGGGGATGACAATAGTTTAGCCAAGGTAACAGTGGATTT
GTTATTACAAAACGGACAAACCGTCACGGCTGCTGAGAGCCTCACCGCTGGCCTATTCCAAAGTACACTGGGGGAAATTG
CGGGTGCTTCGAAGATTTTTAAGGGAGGCTTCGTGACGTATTCGCAAGAAACAAAAGAGAACTTTTTAGGAATTTCTCAT
GAACTTTTAGAAGAACATGGCACGGTAAGTGAAGCGTGTGCCAAAGAAATGGCAGAGAAAGCGCGTCAGTTAGCTAAATC
TAACTATGGTTTATCATTTACTGGGGTCGCTGGTGACCCAATCGAAGGTCAACCGACAGGCACTGTTTGGATTGGGCTGG
CGGAAGAAGGCCAACCAACCGTTGCAGAATGTTTCCATTTTAACCGTGACCGAAATTATATTAGACAGAGTGCGGTTATG
CGAGGATTAGATCTTTTGCGGCGCCGAATCATTAATAAAAAATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-168)

Competence-damaged protein (CinA)

(258-409)

Damage-inducible protein CinA KH domain (CinA_KH)

(180-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3N3PE98

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

52.392

100

0.529
  cinA Streptococcus mitis SK321

51.537

100

0.527
  cinA Streptococcus mitis NCTC 12261

51.3

100

0.524
  cinA Streptococcus pneumoniae TIGR4

50.591

100

0.517
  cinA Streptococcus pneumoniae D39

50.355

100

0.514
  cinA Streptococcus pneumoniae R6

50.118

100

0.512
  cinA Streptococcus pneumoniae Rx1

50.118

100

0.512
  cinA Bacillus subtilis subsp. subtilis str. 168

48.522

98.068

0.476
  cinA Streptococcus suis isolate S10

44.039

99.275

0.437

Multiple sequence alignment