Detailed information NTG1120359

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: EL092_RS05370
• Genome accession: NZ_LR134291
• Coordinates: 1115887..1116561 (+)
• Length: 224 a.a.
• NCBI ID: WP_048774883.1
• Uniprot ID: -
• Organism: Streptococcus gordonii strain NCTC7868
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1110887..1121561

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL092_RS05345 (NCTC7868_01065)	-	1111185..1111481 (+)	297	WP_012000479.1	hypothetical protein	-
EL092_RS05350 (NCTC7868_01066)	-	1111490..1111816 (+)	327	WP_012000480.1	hypothetical protein	-
EL092_RS05355 (NCTC7868_01067)	-	1111947..1114490 (+)	2544	WP_012000481.1	M1 family metallopeptidase	-
EL092_RS05360 (NCTC7868_01068)	-	1114547..1115089 (-)	543	WP_012000482.1	biotin transporter BioY	-
EL092_RS05365 (NCTC7868_01069)	-	1115301..1115756 (+)	456	WP_012000483.1	hypothetical protein	-
EL092_RS05370 (NCTC7868_01070)	ciaR	1115887..1116561 (+)	675	WP_048774883.1	response regulator transcription factor	Regulator
EL092_RS05375 (NCTC7868_01071)	ciaH	1116551..1117951 (+)	1401	WP_012000485.1	sensor histidine kinase	Regulator
EL092_RS05380 (NCTC7868_01072)	-	1117953..1118879 (+)	927	WP_012000486.1	ketopantoate reductase family protein	-
EL092_RS05385 (NCTC7868_01073)	-	1118903..1120354 (-)	1452	WP_012000487.1	alpha-amylase	-
EL092_RS05390 (NCTC7868_01074)	rpsT	1120581..1120829 (-)	249	WP_008808726.1	30S ribosomal protein S20	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25375.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=1120359 EL092_RS05370 WP_048774883.1 1115887..1116561(+) (ciaR) [Streptococcus gordonii strain NCTC7868]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=1120359 EL092_RS05370 WP_048774883.1 1115887..1116561(+) (ciaR) [Streptococcus gordonii strain NCTC7868]
ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATCTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGATGGCTTTCAAGTTTTGAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGAGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATAATTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAATAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	90.179	100	0.902
ciaR	Streptococcus pneumoniae Rx1	90.179	100	0.902
ciaR	Streptococcus pneumoniae D39	90.179	100	0.902
ciaR	Streptococcus pneumoniae R6	90.179	100	0.902
ciaR	Streptococcus mutans UA159	90.135	99.554	0.897
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.556	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.366
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362